Oxytocin Research

Huc M, Nikolic M, Power L, McQuaid RJ, Jaworska N

Receptors for oxytocin, testosterone, estrogen and progesterone exist in brain structures involved in emotional processing. Together, these hormones might play an important role in accounting for sex difference in face expression recognition, wherein females typically outperform males. However, e...

Busnelli M, Gori A, Chini B

G protein-coupled receptors can assemble into both homodimers and heterodimers. While heterodimerization has been extensively characterized, the functional consequences of homodimerization on G protein coupling, signaling, and trafficking remain poorly understood. Oxytocin receptors (OTRs) form h...

Fitzek MP, Kleist P, Handtmann C, Overeem LH, Hoehne CL, Lange KS et al.

Oxytocin has been implicated in migraine pathophysiology through its roles in pain modulation and vascular regulation. Its receptors are present in migraine-related brain regions and cerebral vessels and interact with key migraine mediators such as calcitonin gene-related peptide (CGRP). Declinin...

Kunarathnam V, Dar M, Asad M, Itzhak I, Itzhak P

Uterine rupture typically occurs in women with prior uterine surgery, but spontaneous rupture in an unscarred uterus is rare. This report highlights such an event in a low-risk gravida following labor induction. This case report is about a 35-year-old gravida 2, para 1 woman at 40 weeks and two d...

Siegler Lathrop T, Martínez Sanchez I, Chronakis IS, Diaz Heijtz R

The maternal perinatal environment shapes brain development and long-term neurodevelopmental trajectories. Probiotic supplementation during this period has emerged as a promising strategy to support healthy neurodevelopmental outcomes through modulation of immune and synaptic plasticity pathways....

Cheng Y, Burrows E, Zrinzo L, Akram H, Robbins TW, Tyagi H et al.

Body dysmorphic disorder (BDD) is a severe psychiatric disorder characterized by excessive preoccupation with perceived flaws in appearance. In this review, we aim to synthesize the latest findings on the neurobiology of BDD and propose an updated BDD neurocircuitry model.A systematic search iden...

Ren X, Ding L, Jiang Y

Attention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder in children. Long Mu Ning Xin Decoction (LMNXD) shows established clinical efficacy against ADHD, yet its mechanistic basis is not fully elucidated.This study investigates the therapeutic potential of LMNXD...

Verbalis JG

Hyponatremia is the most frequently encountered electrolyte disorder in clinical practice. Understanding the pathophysiology of the many different etiologies of hyponatremia is essential for appropriate diagnosis and therapy of hyponatremic disorders. Hyponatremia can occur by an increase in tota...

Söröd M, Gyllencreutz E

Cardiotocography (CTG) is used for fetal surveillance to prevent asphyxia related neonatal outcomes during pregnancy and delivery. In Sweden, all delivery wards have transitioned from CTG registered and printed on paper inside the delivery room, to digital central fetal monitoring where CTG is vi...

Karakulak ŞI, Bulut SD, Karadağ H, Koçer ZA

This study examined serum oxytocin levels during an acute psychotic episode and following antipsychotic treatment response in male patients with schizophrenia, and explored associations with social cognition and functional cognitive domains.The sample consisted of 51 male patients meeting DSM-5 c...

de Oliveira GA, Gomes PM

Yuan S, Zhang YQ

Oxytocin (Oxt) plays a crucial role in forming stable social bonds and promoting social interactions in both humans and animals. During the long history of domestication, dogs have evolved advanced social communication, empathy, and a remarkable ability to perceive and respond to human emotions. ...

Shi J, Shen P, Zhang X, Su M, Tang M, Gao Y et al.

Elagolix sodium (ELS), a non-peptide oral gonadotropin-releasing hormone receptor (GnRH) antagonist approved for the treatment of endometriosis-associated pain, displays atypical gelation in aqueous environments along with challenging physical properties such as high hygroscopicity. To address th...

Bos PA, Spencer H, Buisman RSM

Empathy is a core motivational driver of human caregiving, shaped by evolution to ensure the survival of dependent others. Human caregiving consists of two complementary components that are each supported by distinct neuroendocrine systems: nurturance, which flourishes under safety, and protectio...

Thanekar R, Taksande B, Umekar M, Vinchurney M

Nicotine addiction is a chronic relapsing disorder driven by neuroadaptive changes in reward, stress, and emotional regulation systems. Withdrawal symptoms, including anxiety, irritability, cravings, and anhedonia, significantly hinder smoking cessation efforts. Despite current treatment options ...

Jung Y, Yoon M

Oxytocin (OXT) plays a crucial role in regulating the serotonin (5-HT) system and behavior. Although previous studies have reported significant relationships among OXT, 5-HT, and behavioral responses, the effects of OXT on 5-HT concentrations and behavioral traits in horses remain poorly understo...

Zheng Z, Feng Y, Yin W, Guo D, Pei Y, Kong Q et al.

This study aims to investigate the effect of misoprostol combined with oxytocin versus oxytocin alone on improving the cervical Bishop score during term labor induction and its impact on delivery outcomes. A retrospective analysis was conducted on 200 pregnant women who underwent term labor induc...

Butler MG

Prader-Willi (PWS) and Angelman (AS) syndromes were the first examples in humans with errors in genomic imprinting, usually from de novo 15q11-q13 deletions of different parent origin (paternal in PWS and maternal in AS). Dozens of genes and transcripts are found in the 15q11-q13 region, and may ...

Gangitano E, Rossetti R, Tozzi R, Nevi P, Masi D, Basciani S et al.

Background/Objectives: Obesity is a chronic relapsing disorder associated with many comorbidities. Some evidence suggests that oxytocin (OT) has an anorexigenic effect, but its levels are often increased in obesity. This study investigates the effects of weight loss induced by a very-low-calorie ...

Gabbai D, Gilboa I, Berkovitz Shperling R, Reicher L, Attali E, Yogev Y et al.

Objective: To identify risk factors for intrapartum cesarean delivery (CD) among women with obesity (BMI ≥ 30) and to evaluate whether a machine learning model (XGBoost) can improve prediction of this outcome compared with a previously developed regression-based risk score. Methods: A retr...