Orexin-A Research

Qi J, Liu Q, Cheng J, Jiang J, Wei X, Meng Q et al.

Shift work and social jetlag groups are at higher risk for depression, with the unfixed light pattern (ULP) potentially serving as one of critical risk factors. Evidence suggests that the ULP induces depressive phenotypes in rodents, possibly mediated by the circadian-orexinergic system. Blue lig...

Kirsz K, Zięba DA

Orexin-A and orexin-B are hypothalamic neuropeptides that coordinate arousal, metabolic, and reproductive functions through orexin receptor 1 (OX1R) and orexin receptor 2 (OX2R). This review synthesizes evidence from humans, experimental models, and domestic species to examine how orexin signalin...

Ergani AC, Tezcan ME, Can Ü, Arslan Kılıçoğlu E

Malnutrition and sleep disturbances are common in childhood and are associated with neuropeptides that regulate appetite and circadian rhythms. Hypothalamic peptides such as orexin A, agouti-related protein (AgRP), proopiomelanocortin (POMC), and peptide YY (PYY) play important roles in energy ba...

Gnazzo M, Pisanò G, Baldini V, Citeroni F, Canulli F, De Ronchi D et al.

Narcolepsy type 1 (NT1) and narcolepsy type 2 (NT2) are rare, chronic neurologic disorders of hypersomnolence. Narcolepsy type 1 results from the selective loss of orexin-producing neurons, leading to markedly reduced levels of orexin neuropeptides in the brain and CSF. NT2 shares some symptoms w...

Steven C, Skylynn T, Bardya H, Megha B, Helen V, Lee D et al.

Obesity is a growing global epidemic, contributing to major health conditions such as cardiovascular disease (CVD), stroke, type 2 diabetes mellitus (T2DM), and cancer. The purpose of this review is to evaluate and compare obesity management strategies, with a focus on the magnitude of weight los...

Burckhardt A, Rakowsky A, Kahl E, Morchhale S, Mayer D, Panagiotou N et al.

Schizophrenia encompasses positive, negative, and cognitive symptoms, and accumulating evidence suggests that the orexin system may modulate circuits relevant to these domains. Here, we investigated whether orexin-related interventions influence schizophrenia-like behaviors induced by the NMDA re...

Uluc F, Celik BG, Karabork S, Horasan N, Turkoglu SA, Boztas MH et al.

Katsuragi T, Tozawa T, Yamada S, Ogi H, Tanaka M, Iehara T et al.

Maternal obesity is a risk factor for neurodevelopmental disorders in the offspring. In recent years, it has been suggested that not only maternal obesity but also dietary intake during pregnancy and lactation may influence children's behaviour and neurodevelopment. In the present study, we aimed...

Monda A, Casillo M, Allocca S, Moscatelli F, La Marra M, Monda V et al.

Intermittent fasting and ketogenic dietary approaches are increasingly investigated for their potential metabolic benefits in obesity. However, their long-term neuroendocrine effects-particularly those involving Orexin-A, a peptide implicated in energy regulation-remain poorly understood. The obj...

Follin LF, Viste R, Vevelstad J, Langdalen K, Hansen BH, Grande RKB et al.

Narcolepsy type 1 (NT1) is characterized by fragmented sleep, yet brief transitions may be concealed in traditional 30-second epochs. We therefore aimed to assess sleep fragmentation in NT1 patients and their non-narcoleptic siblings using 5-second mini-epochs.We analyzed sleep stages from human-...

Deventer MH, Mori S, Angermann M, Decker M, Stove CP

The excitatory neuropeptides orexin-A and -B interact with their target G protein-coupled receptors (GPCRs), the orexin 1 and orexin 2 (OX1 and OX2) receptors, which are widely expressed throughout the central nervous system. The orexin system plays a critical role in regulating several physiolog...

Han S, He K, Cao L, Li S, Huang L

Postoperative delirium (POD) and sleep disorders are common surgical complications with a close clinical association, suggesting shared pathophysiological mechanisms mediated by neurotransmitters and neural circuits. Using a mouse model of laparotomy under sevoflurane anesthesia, we assessed deli...

Schubert F, Heyer J, Lunemann M, Arens J, Steinseifer U, Jansen SV et al.

Each year, over half a million children worldwide are born extremely prematurely (EPI), often requiring potentially harmful ventilatory support. An artificial placenta with gas exchange provided by an oxygenator offers an alternative. However, current oxygenators are not designed for long-term ap...

Almahwzi S, Ghabashi S, Alyami W, Alsolami J, Juma R, Alghamdi S et al.

Orexin-A, a neuropeptide involved in regulating physiological processes, has potential implications in psychiatric disorders. Studies examining orexin-A levels in schizophrenia, bipolar disorder, and major depressive disorder have produced conflicting results, highlighting the need for further re...

Rahman MM, Shim YW, Kim YH, Park CK

Peptides play crucial roles in pain regulation. Following tissue injury or insults, many endogenous excitatory peptides, such as calcitonin gene-related peptide, substance P, nerve growth factor, bradykinin, hemokinin-1, cholecystokinin, and endothelin, are generated, which are eventually respons...

Jo J, Kim JY, Leem J

In the original publication [...].

Horiuchi D, Irukayama-Tomobe Y, Kim JD, Kasuya Y, Nemoto T, Suzuki T et al.

Alterations in the immune system, stemming from sleep/wakefulness disorders, increase the risk of inflammatory pathologies. Orexin, a hypothalamic neuropeptide, regulates sleep and wakefulness. However, the role of orexin in inflammatory responses-whether it is protective or pathological-is still...

Costello A, Linning-Duffy K, Shi J, Lonstein JS, Yan L

Seasonal affective disorder (SAD) is a major depressive disorder recurring in fall and winter due to daytime light deficiency. To investigate underlying mechanisms of SAD, we previously developed a diurnal model using Nile grass rats (Arvicanthis niloticus), in which a winter-like dim daylight co...

Sun L, Jiang L, Gu Z, Zhao P, Xiang D, Man J et al.

We aimed to expound the effects of different doses of dexmedetomidine (Dex) combined with stellate ganglion block (SGB) on postoperative pain, sleep quality, and serum orexin A levels in patients undergoing general anaesthesia for laparoscopic radical resection for colorectal cancer (CRC).This pr...

Ağlıç Y, Kale İ

Orexin-A (OXA) is a hypothalamic neuropeptide implicated in glucose regulation and insulin sensitivity. Given the central role of insulin resistance in polycystic ovary syndrome (PCOS), this study evaluated serum OXA levels in women with PCOS.This cross-sectional case-control study included 88 wo...