Octreotide Research

Slott C, Langer SW, Oturai P, Møller S, Hansen CP, Kjaer A et al.

Small intestinal neuroendocrine tumors (siNET) are rare malignancies, often diagnosed at advanced stages with metastatic spread. While surgery is the only curative treatment, medical therapies, including somatostatin analogues (SSA), peptide receptor radionuclide therapy (PRRT), and other systemi...

Chauhan A, Kizilgul M, Racila E, Zekarias K

Carcinoid syndrome from pulmonary carcinoids without hepatic metastases is rare and diagnostically challenging when biochemical markers are normal.A woman in her mid-60 s presented with an incidental right adrenal mass during evaluation for dyspnea and elevated D-dimer. She reported a 20-y...

Degryse L, Teles L, De Vleeschouwer S, Boeckxstaens L, Jentjens S, Deckers W et al.

This study aims to evaluate differences in PET/CT imaging of meningioma using both gallium-68- and fluorine-18-labelled somatostatin receptor (SSTR) tracers, to characterize incidentally detected meningiomas on SSTR PET/CT, and to analyse institutional experience with Peptide Receptor Radionuclid...

Gaudillière M, Armand T, Senée V, Villanueva C, Nicolino M, Perge K et al.

Kabuki syndrome (KS) is a rare disease predisposing to congenital hyperinsulinism (CHI). The incidence of CHI in KS may be higher than considered in practice, and appropriate management of hypoglycemia would reduce long-term neurologic morbidity in these patients. Thus, the aims of our study were...

Pouriki S, Karagiannis D, Agapitou T, Rautopoulou A, Mastora Z

Empyema and chylothorax are distinct but serious pleural space complications, with the simultaneous occurrence being exceedingly rare and clinically challenging. We present the case of a 78-year-old immunocompromised male with small-cell lung cancer who developed concurrent empyema and chylothora...

Prasad N, Bijjam R, Kathi PR, Mittal V

Pancreaticopleural fistula (PPF) is an uncommon complication of pancreatitis that typically presents with respiratory symptoms rather than classic epigastric pain. PPF often occurs in settings of alcoholic pancreatitis with pancreatic pseudocyst rupture or ductal disruption, leading to abnormal p...

Chen X, Guo S, Li YG, Liu AK, Kuang J, Shi P et al.

Somatostatin receptor 3 (SSTR3) exerts critical biological functions such as negatively regulating hormone release and cell proliferation, making it a promising therapeutic target for endocrine disorders and nonfunctioning pituitary tumors. However, the development of more effective and safer som...

Jóźwik-Plebanek K, Saracyn M, Durma AD, Kołodziej M, Mądra W, Dziuk M et al.

Evidence on the efficacy and safety of radioligand therapy (RLT) in lung neuroendocrine tumors (LNETs) remains scarce. The limited data available, derived mainly from retrospective analyses are based on small patient cohorts and heterogeneous treatment protocols. The objective of this study was t...

Choucair A, Zdunek A, Liao M, Bodei L, Deandreis D, Das J et al.

Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors originating from neural crest-derived chromaffin tissue, marked by clinical heterogeneity and substantial genetic underpinnings. With up to 70% of cases linked to germline or somatic mutations, including Succinate DeHydro...

Chang M, Willis GC

Hypoglycemia is commonly encountered in the emergency department. Patients can present with a myriad of symptoms and its presentation can mimic other more serious diagnoses. Despite the relative ease of its management, clinicians often miss the diagnosis or mismanage it even when discovered. Gluc...

Jourdain A, Leenhardt R, Popa I, Dray X

A 47-year-old woman with Turner's syndrome was admitted to the emergency room with anemic syndrome and melena. She has a history of hypothyroidism, premature ovarian insufficiency and chronic iron deficiency. She reported previous overt gastrointestinal (GI) bleeding attributed to duodenal vascul...

Dillon BR, Ruddy M, McQuade EC, Shah SN, Twi-Yeboah A, Levinson BA et al.

Acromegaly is a rare, insidious disease associated with significant morbidity and mortality usually caused by a growth hormone (GH)-secreting pituitary tumor. Somatic mutations in GNAS are common in these tumors, yet their diagnostic, prognostic, and therapeutic implications are less clear.We con...

Jin M, Shi P, Yu Y

To systematically evaluate the clinical features and effects of octreotide long-acting release in the treatment of autosomal dominant polycystic kidney disease (ADPKD).Databases were searched for randomized controlled trials (RCTs) evaluating octreotide long-acting release (LAR) in ADPKD from inc...

Nic Ionmhain Ú, Coulson L, Roberts DM

High-dose insulin is a treatment for poisoning-induced cardiogenic shock. There is a risk of hypoglycaemia after discontinuing high-dose insulin due to persistent hyperinsulinaemia. The pharmacokinetics of insulin after discontinuing high-dose insulin are poorly defined, with previous publication...

Peng G, Lei X, Leng W, Wu F, Xie L, Long M et al.

Thyroid-stimulating hormone pituitary adenomas (TSHomas) are a rare cause of central hyperthyroidism, characterized by abnormally high TSH levels, and typically respond to somatostatin analogue (SSA). We report a young patient with SSA-insensitive TSHoma where Lugol's solution facilitated surgica...

Elballa WM, Gregory A, Siahaan TJ, Hageman MJ

In vitro models used to investigate drug diffusion face certain limitations and challenges because they omit for mucus interactions that could influence diffusional transport. This study developed a simple mono-component mucin model using Mucin Type II from porcine stomach to predict the effects ...

Li B, Ji ZH, Liu G, Yu Y, Li Y

This study aimed to compare the efficacy and safety of perioperative somatostatin versus octreotide in peritoneal carcinomatosis (PC) patients after cytoreductive surgery (CRS) + hyperthermic intraperitoneal chemotherapy (HIPEC).Peritoneal cancer patients treated with CRS +&#...

Hu H, Chen K, Xiao H, Lan X

Primary hepatic neuroendocrine carcinoma (PHNET) is an exceptionally rare malignancy with limited standardized treatment options.Two patients presented with incidentally detected hepatic masses and nonspecific gastrointestinal symptoms.Case 1 was diagnosed as primary hepatic neuroendocrine carcin...

Wu Y, Cao X, Yu L, Yao J, Sun C, Ruan J et al.

Chemotherapy-induced diarrhea (CID) is one of the gastrointestinal adverse effects in cancer patients after chemotherapy, which seriously affects the course of chemotherapy and reduces the survival rate of patients. The medications commonly used to improve CID include loperamide and octreotide. H...

Gallicchio R, Milella M, Giordano A, Cives M, Storto R, Nardelli A et al.

IntroductionThe somatostatin receptor (SSTR) standardized uptake value (SUVmaxsstr) obtained by [68Ga]Ga-edotreotide positron emission tomography-computed tomography ([68Ga]Ga-SSTR PET/CT) helps recognize patients with metastatic gastroenteropancreatic neuroendocrine tumors (GEP-NETs) who are at ...