Noopept Research

Vikal A, Maurya R, Patel BB, Patel P, Kumar M, Kurmi BD et al.

Cognitive enhancement, aimed at improving or preserving memory, attention, and executive functions, has gained significant interest from both the scientific community and the public. This review explores various strategies for enhancing cognitive function, including natural compounds, synthetic e...

Vanhee C, Deconinck E, George M, Hansen A, Hackl A, Wollein U et al.

In recent years, an increasing number of case reports have mentioned the presence of illicit nootropics, smart drugs or mind doping products on the market. To better understand the extent of the problem, a market surveillance study was organised by the General European Official Medicines Control ...

Araj SK, Szeleszczuk Ł, Gubica T, Zielińska-Pisklak M, Bethanis K, Christoforides E et al.

N-Phenylacetyl-L-prolylglycine ethyl ester (Noopept, GVS-111, omberacetam) is an orally available active pharmaceutical ingredient (API), with neuroprotective properties and ability to enhance cognitive function. It belongs to nootropic family of drugs and is included in the group of racetams, al...

Chen ZH, Yuan XH, Tu TT, Wang L, Mao YH, Luo Y et al.

In this study, polysaccharides (RRTPs) were extracted from Rosa roxburghii Tratt pomace by hot water or ultrasound (US)-assisted extraction. The structural properties and potential prebiotic functions of RRTPs were investigated. Structural characterization was conducted through HPAEC, HPGPC, GC-M...

Erokhina PD, Abalenikhina YV, Mylnikov PY, Petrov AV, Ganina SO, Konyakhin EA et al.

In experiments on HepG2 cells, we studied the effect of the original domestic neurotropic drugs omberacetam, fabomotizole, and ethylmethylhydroxypyridine succinate (EMHPS) (1-500 μM) on the activity and content of organic anion transporting polypeptides OATP1B1 and OATP1B3. It was shown tha...

Gurbuz P, Duzova H, Taslidere AC, Gul CC

Diabetes mellitus (DM) is a chronic disease at all ages including childhood and puberty. Failure to treat DM can cause retinopathy, nephropathy and neuropathy. Endocrine and metabolic changes during the pubertal period complicate management of DM. Noopept is a cognitive enhancer that exhibits ant...

Dagda RK, Dagda RY, Vazquez-Mayorga E, Martinez B, Gallahue A

Parkinson's Disease (PD) is a brain-degenerative disorder characterized by a progressive loss of midbrain dopamine neurons. Current standard-of-care includes oral administration of Levodopa to address motor symptoms, but this treatment is not disease-modifying. A reduction in Protein Kinase A (PK...

Kondratenko RV, Povarov IS, Kolbaev SN, Derevyagin VI, Ostrovskaya RU, Gudasheva TA et al.

Noopept (NP) is a proline-containing dipeptide with nootropic and neuroprotective properties. We have previously shown that NP significantly increased the frequency of spontaneous IPSCs in hippocampal CA1 pyramidal cells mediated by the activation of inhibitory interneurons in stratum radiatum. T...

Cohen PA, Avula B, Wang YH, Zakharevich I, Khan I

To identify the presence of unapproved pharmaceutical drugs in over-the-counter dietary supplements marketed to improve memory and cognitive function.Supplements were identified by searching 2 supplement databases for products labeled as containing omberacetam, aniracetam, phenylpiracetam, or oxi...

Düzova H, Nazıroğlu M, Çiğ B, Gürbüz P, Akatlı AN

Neuropathic pain and oxidative neurotoxicity are two adverse main actions of diabetes mellitus (DM). The expression levels of calcium ion (Ca2+) permeable TRPV1 channels are high in the dorsal root ganglion (DRGs) and hippocampus (HIPPO). TRPV1 is activated by capsaicin and reactive free oxygen r...

Srivastava PK, Thakkar HP

Noopept (NPT), a potent neuroprotective agent, suffers the problem of poor oral bioavailability (~10%) and thus demands exploration of ways of bioavailability improvement. Present work focuses on confronting this issue via development of NPT loaded ultradeformable liposomes (UDL) and its further ...

Taghizadeh M, Maghsoudi N, Manaheji H, Akparov V, Baniasadi M, Mohammadi M et al.

[This retracts the article DOI: 10.1016/j.heliyon.2021.e06219.].© 2021 The Author(s).

Taghizadeh M, Maghsoudi N, Manaheji H, Akparov V, Baniasadi M, Mohammadi M et al.

There are largely unknown associations between changes in pain behavior responses during persistent peripheral inflammation and spinal cell alteration such as apoptosis. Some evidence suggests that microglia and microglia related mediators play notable roles in induction and maintenance of centra...

Zainullina LF, Ivanova TV, Sadovnikov SV, Vakhitova YV, Seredenin SB

The effect of noopept (N-phenylacetyl-L-prolyl-glycine ethyl ester) on the DNA-binding activity of HIF-1 in SH-SH5Y cells and the mechanisms of stabilization of this transcription factor were studied in vitro. Noopept was shown to increase both the basal DNA-binding activity of HIF-1 and the acti...

Crawford C, Wang YH, Avula B, Bae JY, Khan IA, Deuster PA et al.

Context: Public health concerns are emerging surrounding huperzine A commonly found in dietary supplements. We sought to determine the actual content of products claiming to contain huperzine A and whether the ingredients on the supplement facts labels matched the analyses.Methods: We identified ...

Ostrovskaya RU, Yagubova SS, Zhanataev AK, Anisina EA, Gudasheva TA, Durnev AD et al.

In experiments on BALB/c mice, prediabetes was modeled by administration of streptozotocin in a dose of 130 mg/kg. DNA damage was assessed by the method of DNA comets. Noopept (0.5 mg/kg intraperitoneally) was administered for 14 days before and for 6, 13, or 14 days after streptozotocin administ...

Belenichev I, Burlaka B, Puzyrenko A, Ryzhenko O, Kurochkin M, Yusuf J et al.

General anesthesia may cause damage of the central nervous system and cognitive dysfunction in the postoperative period. A new intranasal form of Noopept (N-Phenylacetyl-L-prolylglycine ethyl ester) was developed by our team at the Department of the medical technology (Zaporizhzhia State Medical ...

Gürbüz P, Düzova H, Yildiz A, Çakan P, Kaya GB, Bağ HGG et al.

Type 1 diabetes (T1DM) is a common chronic disease in childhood. Increasing insulin resistance in puberty gives rise to higher doses of insulin usage in treatment. Of this reason new approaches in treatment are needed. Noopept researches suggest it to have anti-diabetic properties. We tried to de...

Zainullina LF, Ivanova TV, Ostrovskaya RU, Gudasheva TA, Vakhitova YV, Seredenin SB et al.

Effects of Noopept (N-phenylacetyl-L-prolylglycine ethyl ester) on the relative level of proliferation marker Ki-67 and cell cycle parameters were studied in HEK293 and SH-SY5Y cell lines. The previously established multifactorial mechanism of action of the drug includes enhancement of neurotroph...

Boyko SS, Zherdev VP, Shevchenko RV

The study of the pharmacokinetics of new drugs and the identification of active metabolites is a necessary step for effective and safe use in the clinical practice. It is especially important for peptide drugs due to their enzymatic instability, low bioavailability and poor permeability through t...