NGF Mimetic Peptides Research

Georgelou K, Saridaki EA, Apostolidou CP, Mallios X, Papagiannaki A, Karali K et al.

Emerging neurotrophin treatments for optic nerve injury (ONI) aim to prevent the loss of retinal ganglion cells (RGCs) and enhance axonal regeneration. Microneurotrophins (MNTs), small-molecule mimetics of neurotrophins, have shown neuroprotective effects in various animal models of neurodegenera...

Yeh SI, Ho TC, Chu TW, Chen SL, Ou R, Tsao YP et al.

OBM1701, a pigment epithelium-derived factor-derived short peptide, can eliminate corneal neovascularization by blocking endothelial cell angiogenesis. Activation of hypoxia-inducible factor (HIF)-1α in the retinal pigment epithelium (RPE) is critical for the pathogenesis of choroidal neova...

Joy S, Mi T, Lyu RL, Pewklang T, Thompson T, Sefiani A et al.

Neurotrophins (NTs, including NGF, BDNF, NT-4, and NT-3) are extracellular cytokines which modulate the survival and growth of cells expressing tropomyosin receptor kinases (Trks) A-C. Cells which express Trks include many neural tissues. For instance, corneal nerves secrete NTs to counteract epi...

Zhang X, Wang S, Yang Q, Chen A, Dong S, Liao L et al.

Reinnervation is of great significance for bone regeneration and remodeling. Although great progress has been made in bone tissue engineering, reconstruction of neural networks is still a challenge and leads to limited osteogenesis. Nerve growth factor (NGF) guides the innervation in the early st...

Zhao Y, Liu J, Hu L, Yao X, Tu R, Goto T et al.

Neurovascular network damage and excessive hydrogen peroxide (H2O2) accumulation are the main obstacles for osteoporotic bone defect repair. It is extremely essential to endow the implants with sequential neuroangiogenesis promotion and osteoporosis pathological microenvironment improvement. Hot ...

Numakawa T, Kajihara R

Among neurotrophins, including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4/5), BDNF has been extensively studied for its physiological role in cell survival and synaptic regulation in the central nervous system's (CNS's) neu...

Xia Q, Chang KC, Sun Y, Nahmou M, Noro T, Cheng Y et al.

Stem cell-derived secreted factors could protect neurons in neurodegenerative disease or after injury. The exact neuroprotective components in the secretome remain challenging to discover. Here we developed a cell-to-cell interaction model to identify a retinal ganglion cell (RGC)-protective fact...

Kokkali M, Karali K, Thanou E, Papadopoulou MA, Zota I, Tsimpolis A et al.

Alzheimer's Disease (AD) is an incurable and debilitating progressive, neurodegenerative disorder which is the leading cause of dementia worldwide. Neuropathologically, AD is characterized by the accumulation of Aβ amyloid plaques in the microenvironment of brain cells and neurovascular wal...

Mutoh T, Niimi Y, Ueda A

Although cigarette smoking is known to be a critical risk factor for various organ systems and cancers, accumulating evidence indicates that nicotine - a main constituent of cigarette smoking - can exert neuroprotective effects on neuronal cells through nicotinic acetylcholine receptors (nAChRs)....

Napoli D, Orsini N, Salamone G, Calvello MA, Capsoni S, Cattaneo A et al.

Retinitis pigmentosa (RP) is a family of genetically heterogeneous diseases still without a cure. Despite the causative genetic mutation typically not expressed in cone photoreceptors, these cells inevitably degenerate following the primary death of rods, causing blindness. The reasons for the "b...

Latini L, De Araujo DSM, Amato R, Canovai A, Buccarello L, De Logu F et al.

Retinal ganglion cells (RGCs) are the output stage of retinal information processing, via their axons forming the optic nerve (ON). ON damage leads to axonal degeneration and death of RGCs, and results in vision impairment. Nerve growth factor (NGF) signalling is crucial for RGC operations and vi...

Zaninelli TH, Fattori V, Heintz OK, Wright KR, Bennallack PR, Sim D et al.

Endometriosis is a chronic inflammatory disease that affects ∼10 % of women. A significant fraction of patients experience limited or no efficacy with current therapies. Tissue adjacent to endometriosis lesions often exhibits increased neurite and vascular density, suggesting tha...

Fukuyama Y, Kubo M, Harada K

Neurotrophins (NGF, BDNF, NT3, NT4) can decrease cell death, induce differentiation, as well as sustain the structure and function of neurons, which make them promising therapeutic agents for the treatment of neurodegenerative disorders. However, neurotrophins have not been very effective in clin...

Kan BF, Liu XY, Han MM, Yang CW, Zhu X, Jin Y et al.

The role of nerve growth factor (NGF)/tyrosine kinase A receptor (TrKA) signaling, which is activated in a variety of pain states, in regulating membrane-associated δ-opioid receptor (mDOR) expression is poorly understood. The hypothesis was that elevated NGF in bone cancer tumors could upr...

Cherief M, Xu J, Li Z, Tower RJ, Ramesh S, Qin Q et al.

Peripheral neurons terminate at the surface of tendons partly to relay nociceptive pain signals; however, the role of peripheral nerves in tendon injury and repair remains unclear. Here, we show that after Achilles tendon injury in mice, there is new nerve growth near tendon cells that express ne...

Mallick M, Yoithap Prabhunath TR, Kumari S, Sobhia ME

Ameloblastoma is a benign odontogenic jawbone tumor. The binding of Nerve growth factor (NGF) to receptor tyrosine kinase A (TrkA) promotes cell survival, proliferation, and differentiation via PI3K/AKT and Ras/MAPK signaling. Although the exact cause of ameloblastoma remains unknown, elevated le...

Tiberi A, Borgonovo G, Testa G, Pacifico P, Jacob A, Di Caprio M et al.

Rett syndrome is a rare genetic neurodevelopmental disease, affecting 1 in over 10 000 females born worldwide, caused by de novo mutations in the X-chromosome-located methyl-CpG-binding protein 2 (MeCP2) gene. Despite the great effort put forth by the scientific community, a therapy for this deva...

Atkinson E, Dickman R

Traumatic brain injury (TBI) is a leading cause of disability in adults, caused by a physical insult damaging the brain. Growth factor-based therapies have the potential to reduce the effects of secondary injury and improve outcomes by providing neuroprotection against glutamate excitotoxicity, o...

Sun XM, Ji HG, Gao X, Wang XD

This study investigated the effect of Lianmei Qiwu Decoction(LMQWD) on the improvement of cardiac autonomic nerve remodeling in the diabetic rat model induced by the high-fat diet and explored the underlying mechanism of LMQWD through the AMP-activated protein kinase(AMPK)/tropomyosin receptor ki...

Mariano A, Bigioni I, Marchetti M, Scotto d'Abusco A, Superti F

Respiratory viral diseases are among the most important causes of disability, morbidity, and death worldwide. Due to the limited efficacy or side effects of many current therapies and the increase in antiviral-resistant viral strains, the need to find new compounds to counteract these infections ...