Neurotensin Research

Papa A, Balzan S, Lubrano V, Sabatino L

Atherosclerosis and diabetes are largely recognized as inflammatory disorders underlying cardiovascular disease. C-reactive protein, interleukin-6 and fibrinogen constitute the most established inflammatory biomarkers in clinical practice for the characterization of individuals affected by athero...

Wei S, Yang Z, Yang C, Zhao H, Li Y, Guo Y et al.

Precise design of excited-state intramolecular proton transfer (ESIPT) molecules targeting advanced optoelectronic or biological sensing applications presents a fundamental challenge. Controlling the energy difference (ΔE*) between normal (N*) and tautomeric (T*) excited-state forms is cruc...

Zhao XN, Chang J, Sun HG, Meng H, Yao Y, Deng C et al.

To explore the optimal cutoff value of fetal nuchal translucency (NT) in the Shihezi region and analyze the predictive value of NT and high-risk factors for pregnancy outcomes.This retrospective study included pregnant women who underwent NT screening at the First Affiliated Hospital of Shihezi U...

Ojeda J, Bruno N, Cover K, Zhang WC, Chumbimuni-Torres K

MicroRNAs and isomiRs are promising biomarkers for the detection of diseases such as cancers, but distinguishing the highly similar microRNA sequences between these remains challenging. We report a five-strand four-way junction (5S-4WJ) electrochemical biosensor that combines universal reporter s...

Dick L, Boyle C, Tallentire VR, Norton J, Howie E, Smink DS et al.

Cognitive non-technical skills (NTS), including situation awareness and decision-making, are critical determinants of surgical outcomes. Current NTS assessments depend on expert human observation, which is resource-intensive and difficult to scale. To address this, we investigated whether surgica...

Morimoto K, Yanase K, Kanemitsu S, Dohi T, Kita Y

In this study, we developed a metal-free, intermolecular C(sp2)-H imidation of anilines and phenols using sulfonimides, yielding isolable aryl sulfonimides under facile conditions. MesI(OAc)2 and HNTs2 combine to produce an O-bridged I(III)-NTs2 adduct, which is stabilized via π-π sta...

Fang T, Huang W, Wu Y, Xiao G, Xue Y, Liu M et al.

Epigenetic modifications play pivotal roles in regulating plant adaptive responses to viral infection and various other stresses. However, how viral infection rewires and shapes chromatin-based epigenetic regulatory networks in crops with contrasting resistance remains unclear. To this end, we in...

Kosushkin S, Vassetzky N, Borodulina O, Kramerov D

Short interspersed elements (SINEs) are non-autonomous retroelements that are transcribed by RNA polymerase III from an internal promoter. Most SINE families originate from tRNAs, but a few, exclusively within supraprimates (primates, rodents, tree shrews) and, exceptionally, hagfish, derive from...

Liu L, Wu C, Wang X, Pu C, Xu F, Yang P et al.

Traumatic brain injury (TBI) is recognized as a significant global public health issue associated with high morbidity and mortality. This study aimed to overcome the limitations of traditional prognostic models (e.g., International Mission on Prognosis and Analysis of Clinical Trials, IMPACT) by ...

Nitta N, Sugiyama Y, Sugimura T, Ito T, Ikebata K, Abe H et al.

Cytopathology, often abbreviated as cytology, has a central role in the early detection of cancer, such as cervical, lung and bladder cancers, owing to its speed, simplicity and minimally invasive nature1-9. However, its effectiveness is limited by variability in diagnostic accuracy stemming from...

Ding X, Huang X, Chen N

Many Alexandrium species can develop harmful algal blooms (HABs) associated with paralytic shellfish poisoning (PSP), making their accurate identification critical. Morphological similarity among Alexandrium species limits their identification, whereas molecular marker-based methods are effective...

Gao P, Zhang C, Zhong S, Wei J, Ma H

Neurotensin receptor 1 (NTSR1) is linked with poor prognosis in many tumors, including gastric cancer (GC). However, the exact mechanism by which NTSR1 affects GC anoikis in GC has not yet been clarified. Therefore, this project aimed to figure out the specific mechanism by which NTSR1 participat...

Ghita-Pettigrew M, Kerr BN, Brown KH, Karuna N, Edgar KS, Herron B et al.

The role of the natriuretic peptides in radiation heart injury (RHI) has not been thoroughly examined. Pharmacological modulation of the natriuretic peptide system with sacubitril/valsartan (sac/val) has led to improvements in heart failure therapy and preliminary data suggests RHI is associated ...

Weberling LD, Ochs A, Aus dem Siepen F, Salatzki J, Haney AC, Giannitsis E et al.

Unlike systolic heart function, the assessment of diastolic heart function is often demanding using cardiovascular magnetic resonance (CMR) imaging. This study aims to assess the value of semi-automatic CMR-derived biplane functional parameters in patients with cardiac light chain (AL) and transt...

Yan Y, Liu Y, Guo H

Plant small RNAs (sRNAs) are pivotal regulators of development, genome stability, and environmental adaptation. In plants, endogenous sRNAs are broadly grouped into microRNAs (miRNAs) and small interfering RNAs (siRNAs). siRNAs can be further subdivided into those derived from noncoding transcrip...

Cebrián Cuenca AM, López Zacárez S, Gil Montoya A, Esteban Flores A, González Morales M, García Gómez J et al.

To describe N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels in an outpatient cohort of patients with type2 diabetes mellitus (T2DM) without heart failure, as a marker of cardiac stress and to evaluate the impact of its measurement in the follow-up of these patients.Observational stud...

Farmer DGS, Mori N, Saulsberry L, Canning BJ

Polymodal vagal afferent nerves terminating in the mucosa of the large conducting airways play essential roles in regulating cough. These cough receptors project bilaterally from the nodose ganglia, are activated by protons and by mechanical stimulation, and terminate centrally in the medial (Sol...

Sakai R, Brennen-Xie L, Bassi JK, Connelly AA, Melo M, Allen AM et al.

Autonomic reflexes, controlling unconscious processes such as heart rate and digestion, are essential for homeostasis. Vago-vagal reflexes describe one category of autonomic reflexes in which the sensory input and motor output are both mediated through the vagus nerve. These reflexes are widely c...

Park S, Benda M, Mekhanik A, Milham MP, Hong SJ, Roy AK et al.

Children with attention-deficit/hyperactivity disorder (ADHD) frequently exhibit impairing emotional dysregulation along with inattention and hyperactivity. We aim to parse the heterogeneity of behavioral and emotional dysregulation in ADHD using latent brain factors based on cortical thickness (...

Tabakovic N, Joshi S, Kimman M, Mitalas L, Iqbal N, Tozer P et al.

Cryptoglandular anal fistula is a condition that significantly impairs quality of life in patients. Despite the recent development of the Anal Fistula Core Outcome Set (AFCOS), which identified ten key outcomes, variation in outcome definitions and measurement instruments hampers comparability ac...