Neuropeptide Y Research

Wang N, Guo H, Song L, Wang J, Hu S, Wang M et al.

To investigate the metabolic mechanisms underlying weight regain (WR) after semaglutide withdrawal in females with obesity, focusing on gut microbiota, bile acid metabolism, and central nervous system regulation.In a prospective, single-arm interventional study, 28 women with obesity finished 36-...

Zhang X, Bao H, Hu J, Ren W, He Z, Yu-Taeger L et al.

Chronic neuroinflammation and dysfunction of the neuro-glial-vascular unit (NGVU) are central mechanisms driving the progression of neurodegenerative diseases such as Alzheimer's and Parkinson's disease. Neuropeptides, as key regulatory signaling molecules in the central nervous system (CNS), bin...

Zhang F, Xu H, Zuo Y, Che K, Cui Y, Niu Z et al.

Oligopeptides derived from dietary sources are regarded as ideal functional ingredients for nutritional interventions in diabetes due to their favorable bioavailability, target specificity, and safety profiles. Gynura divaricata (GD), a medicinal food plant, has shown hypoglycemic properties; how...

Caviedes-Bucheli J, Ríos-Osorio N, Pérez-Villota M, Aucú-Miño K, Escobar-Mafla D, Muñoz-Alvear HD et al.

: This study aimed to assess the expression of neuropeptide Y (NPY) in human dental pulp after tooth bleaching with three in-office hydrogen peroxide (H2O2)-based systems.Forty pulps were collected from premolars scheduled for extraction and divided into four groups (n = 10): Control (no bleachin...

Smith MA, Natarajan E, Lizama-Valenzuela C, Arnold T, Stroud D, Larpthaveesarp A et al.

Hypoxic-ischemic (HI) brain injury triggers a dynamic, multi-phase response involving early microglial efferocytosis followed by extracellular matrix (ECM) deposition and scar formation. Arginase-1 (ARG1), a key enzyme in tissue repair, is implicated in both processes, yet its role in neonatal mi...

Han Y, Sun L, Liu Y, Zhang X, Liu H, Zhang H et al.

Epigenetic modifications play a crucial role in the pathogenesis of inflammatory bowel disease (IBD) by mediating gene-environment interactions. We previously showed that UHRF1, a central regulator of DNA methylation, contributes to cancer progression; however, its function in IBD remains poorly ...

Hu F, Yu J, Zheng C, Zhong Y, Shen J, Qiu R et al.

Photoaging, driven by chronic ultraviolet radiation (UVR), disrupts skin structure and function. Traditional retinoids enhance extracellular matrix (ECM) regeneration but cause irritation. Hydroxypinacolone 9-cis retinoate (9-cis HPR), a derivative of 9-cis retinoic acid, selectively activates RA...

Sweeney CAP, Liu H, Dean M, Domingos AI

Focusing on adipose tissue function, this review examines the neuroimmune mechanisms by which sympathetic neurons regulate body weight. Under healthy conditions, anti-inflammatory cues from perineurial barrier cells, mesenchymal cells, and immune cells support sympathetic-adipose communication, i...

Cao P, Geng C, Ren X, Chu X, Zhai Y, Li W et al.

Epilepsy is one of the most common neurological disorders, with current antiepileptic drugs (AEDs) being ineffective in up to 30% of patients. Moreover, the therapeutic efficacy of existing AEDs is significantly limited by the blood-brain barrier (BBB). The neuropeptide Y2 receptor is a potential...

Hodzic S, Riedemann T

Neuropeptides represent a heterogeneous class of signalling molecules whose release has initially been described in the hypothalamus. Their release often follows a circadian rhythm and basal release may be enhanced by internal and external stressors. Research on the cellular actions of neuropepti...

Ibrahim Fouad G, Farouk Aly H, Zaki Rizk M

Cadmium (Cd) is one of the most toxic heavy metals that are commonly present in the environment. Polyphenolic compounds exhibited the potential to mitigate heavy metal-induced organ toxicity. Crocin is a carotenoid compound of saffron. This study investigated the protective potential of crocin ag...

Sun Y, Yang Y, Huang X, Yuan L, Bian Q, Ren J et al.

Utilizing a readily available and highly efficient organic photocatalyst (QXPT-NPy, 0.5 mol %) and inexpensive CBr4 (0.5 mol %) as a bromine radical precursor, the [3 + 2] cycloadditions of vinylcyclopropanes with alkenes/alkynes were successfully achieved under irradiation of 420 nm blue LEDs. A...

Zhao Y, Luo Q, Ren P, Zhang R, Wen Y, Lai H et al.

Atherosclerosis (AS) serves as the pathological foundation for numerous cardiovascular and cerebrovascular diseases and is highly comorbid with depression. The mechanisms underlying this co-morbidity are exceptionally complex, posing significant challenges to effective clinical treatment. Consequ...

Feng Z, He Q, Zheng Y, Zhang Y, Chen X, Liu J et al.

Sucrose is a key quality trait in peanuts, yet high-sucrose varieties are scarce. Although sucrose transporters (SUT/SUC) play crucial roles in sucrose transport and accumulation during seed development, systematic analyses in peanuts are limited. This study conducted a genome-wide analysis of th...

Pastorino M, Desiderio A, Perrella E, Campitelli M, Nigro C, Peluso T et al.

Obesity represents a global health concern, with the hypothalamus playing a central role in regulating energy balance. Chlorpyrifos (CPF), a widely used organophosphate pesticide, is now recognized as an endocrine-disrupting chemical (EDC). Although the peripheral metabolic effects of CPF are rel...

Gan R, Xu D, Liu W, Liu J, Yang Y, Liu N et al.

Neuropeptide Y receptor Y1 (NPY1R) is an excellent potential target in glioma. This study aims to prepare 68Ga/211At-labeled NPY1R-targeting peptide as radiopharmaceuticals for glioma-targeted imaging and therapy. Molecular operating environment (MOE) was used for mutation scanning and design pep...

Zhang X, Xu C, Yu S, Yan A, Peng S, Ma Y et al.

Alcohol withdrawal syndrome manifests clinically as anxiety, fatigue, emotional dysregulation, and sleep disturbances, significantly compromising both physical and psychological well-being. While these behavioral manifestations are known to involve limbic system dysfunction, the precise neural me...

De Zoysa AI, Govinnage J, Giorlando F, Dodd S, Narayanaswamy JC, Berk M et al.

Despite significant advancements in psychopharmacology, there are inadequate treatment options for many psychiatric disorders, including major depressive disorder, bipolar disorder, schizophrenia, and anxiety disorders. This review explores emerging neurobiological targets beyond conventional mon...

Zhu W, Chen C, Wei Y, Sun Y, Gao J, Li J et al.

This study comprehensively characterizes the PEBP gene family in Cymbidium sinense, an orchid with a prolonged vegetative phase that limits its industrial production. Genome-wide analysis identified six CsPEBPs, classified into FT-like, TFL1-like, and MFT-like subfamilies. Evolutionary, gene stru...

Navarro JA, Gavito A, Rivas S, Rodríguez-Martín A, Baixeras E, Decara J et al.

Background: Population aging increases susceptibility to cognitive decline, anxiety, and metabolic dysregulation, yet safe and effective interventions remain limited. Saffron (Crocus sativus L.) has been traditionally used to enhance mood and cognition, and its main metabolites, crocins and safra...