Nesiritide Research

Huang M, Wang L, Wang M, Yuan X, Li M, Long L et al.

Renal ischemia-reperfusion (IR) injury is a major cause of acute kidney injury (AKI), with limited specific therapies. Recombinant human brain natriuretic peptide (rhBNP) shows potential renal protective effects, but its role and mechanism in IR-induced AKI is unclear. The present study showed rh...

Yu H, Li N, Li J, Zhu J

To investigate the efficacy of recombinant human brain natriuretic peptide (rhBNP) therapy after percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI) and its impact on cardiac function.In this retrospective controlled study, 104 AMI patients who underwent PC...

Shao J, Wang L, Shao C, Wang Y, Li J, Luo J et al.

Clinical trials have demonstrated the efficacy of recombinant human brain natriuretic peptide (rhBNP) in managing acute decompensated heart failure. Moreover, since rhBNP performs roles in hemodynamic regulation, neurohormonal balance, and renal function, rhBNP administration could benefit cardia...

Zhang L, Jiang Z, Ma H, Dong L, Feng S, Xu J et al.

Ischemic cardiomyopathy (ICM) with heart failure (HF) is characterized by myocardial hypoxia, microcirculation dysfunction, and neuroendocrine activation. While ivabradine and recombinant human brain natriuretic peptide (rhBNP) are individually used for HF, their combined efficacy remains underex...

Zhang Q, Zhang Y, Han L, Liu M, Yu YB, Wang Y et al.

Objective: To evaluate the sample preparation proficiency and storage proficiency of 11 clinical biobanks in Beijing through simulated experiments, and to establish an assessment method for the quality comparability of biological samples. Methods: An exploratory research design was adopted. In No...

Zhang Y, Fei P, Liu X

This study evaluates the impact of recombinant human brain natriuretic peptide (Rh-BNP) combined with levosimendan on therapeutic efficacy, inflammatory markers, and nutritional status in patients with heart failure (HF).A total of 162 heart failure patients treated between March 2022 and March 2...

Zhang X, Luo Y, Zhao Y, Lu H, Ji X

As an extremely rare genetic disorder, limb-girdle muscular dystrophy type 2Y (LGMD2Y) is associated with progressive muscle weakness and potential cardiac involvement. Despite being less common compared with other muscular dystrophies, cardiac manifestations in LGMD2Y can lead to severe heart fa...

Chioncel O, Mebazaa A, Farmakis D, Abdelhamid M, Lund LH, Harjola VP et al.

Acute heart failure (AHF) affects millions of people each year and vasodilators have been a central part of treatment for over 25 years. The haemodynamic effects of vasodilators vary considerably among individual agents. Some vasodilators, such as nitrates, primarily act on the venous syst...

Gao Y, Cheng Z

Aims/Background Acute left ventricular failure (ALVF), a common cardiovascular emergency characterized by rapid occurring and progressing, poses a severe threat to the patient's life. The purpose of this study is to investigate the impact of combining recombinant human brain natriuretic peptide (...

Ge Z, Li C, Liu Y, Sun X

To analyze the effect of recombinant human brain natriuretic peptide (rhBNP) combined with Xinmailong on heart failure and its impact on cardiac function and inflammatory response.A retrospective analysis was conducted on the clinical data of 60 heart failure patients treated in our hospital...

Meng R, Li X, Liu H, Yi Z, Han Y, Xie Q et al.

Heart failure (HF) in elderly patients with concurrent hypotension presents a therapeutic challenge due to limited standard HF therapies' applicability. Recombinant human brain natriuretic peptide (rhBNP) and vasoactive medications have shown potential in HF management, but their combined efficac...

Meng J, Zuo Y

In this study, we examined whether levosimendan could lower B-type natriuretic peptide (BNP) and improve cardiac function in patients with heart failure who have diuretic resistance and low ejection fraction.We conducted a cohort study among 120 participants from September 2022 to August 2023. We...

Lv Q, Wu Q, Yang Y, Li L, Ye X, Wang S et al.

This network meta-analysis was to compare the efficacy of different drugs on cardiac function, renal function, and clinical outcomes in patients with acute heart failure (AHF) accompanied by renal dysfunction.PubMed, EMBASE, Cochrane Library, and Web of Science were searched to screen all clinica...

Kuang J, Jia Z, Chong TK, Chen J, Liu K, Wang X et al.

Takotsubo syndrome (TTS) primarily manifests as a cardiomyopathy induced by physical or emotional stress, remains a poorly understood condition with no established treatments. In this study, we investigated the potential of sacubitril/valsartan (sac/val) to increase the survival of TTS patients a...

Guo Y, Sun T, Li M, Chen Z, Liu Y, Luo X et al.

Recombinant human B-type natriuretic peptide (rhBNP) has been extensively proven to be an effective mean of heart failure (HF) therapy, but its clinical application is limited by its very short half-life. This study aims to combine in vitro transcribed mRNA (IVT mRNA) and fusion protein technolog...

Xiong X, Guo M

This study aims to evaluate the comparative efficacy and safety of the combination of recombinant human brain natriuretic peptide (rhBNP) and sacubitril/valsartan in the sequential treatment of senile patients with acute heart failure (AHF).The study objects were a total of 136 senile patients ov...

Chen W

Heart failure in elderly individuals poses significant challenges due to the decline in cardiac function associated with aging. This study aimed to investigate the clinical efficacy of recombinant human brain natriuretic peptide (rhBNP) for the treatment of heart failure, especially in elderly pa...

Wang L, Gao Z, Xu Z, Cheng L, Yin S

To investigate the effects of recombinant human brain natriuretic peptide (rhBNP) on efficacy, hemodynamics, and N-terminal pro-brain natriuretic peptide (NT-proBNP) in elderly patients with heart failure (HF).In this retrospective analysis, the clinical data of 112 HF patients who visited the Fi...

Gao Y, Chen B, Han Y, Lu J, Li X, Tian A et al.

Heart failure with preserved ejection fraction is a major global public health problem, while effective risk stratification tools are still lacking. We sought to construct a multi-mRNA signature to predict 1-year all-cause death.We selected 30 patients with heart failure with preserved ejection f...

Kourek C, Briasoulis A, Giamouzis G, Skoularigis J, Xanthopoulos A

Lyophilized recombinant brain natriuretic peptide (BNP) is an exogenous peptide synthesized by artificial recombination technology, with a similar structure and similar physiological effects with the endogenous natriuretic peptide secreted by the human body. It's main mechanism of action is to in...