Nafarelin Research

Chinaka CC, Gannon B, Doust J

This study aimed to highlight trends in the utilisation of selected endometriosis treatments before and after the launch of the National Action Plan for Endometriosis and observe the impact of the action plan on the utilisation of these interventions.Monthly Medicare and Pharmaceutical Benefits S...

Kashiwabara S, Yabe S, Samejima K, Narita T, Itaya Y, Era S et al.

To investigate the efficacy and safety of long-term adjusted low-dose gonadotropin-releasing hormone agonist therapy (GnRH agonist drawback therapy) with nafarelin acetate in patients with uterine fibroids and/or adenomyosis with menstrual symptoms.This single-center, retrospective, observational...

Mittapelly N, Djehizian A, Telaprolu KC, McNally K, Puttrevu SK, Arjmandi-Tash O et al.

Several factors can affect drug release from polylactide coglycolide (PLGA)-based formulations, including polymer and drug properties, formulation components, manufacturing processes, and environmental in vitro or in vivo conditions. To achieve optimal release profiles for specific drug delivery ...

Gautam S, Thakur A, Rajput A, Kumar M

Dengue outbreaks persist in global tropical regions, lacking approved antivirals, necessitating critical therapeutic development against the virus. In this context, we developed the "Anti-Dengue" algorithm that predicts dengue virus inhibitors using a quantitative structure-activity relationship ...

Broni E, Ashley C, Adams J, Manu H, Aikins E, Okom M et al.

The Ebola virus (EBOV) is still highly infectious and causes severe hemorrhagic fevers in primates. However, there are no regulatorily approved drugs against the Ebola virus disease (EVD). The highly virulent and lethal nature of EVD highlights the need to develop therapeutic agents. Viral protei...

Vercellini P, Bandini V, Buggio L, Barbara G, Berlanda N, Dridi D et al.

Is it possible to reduce the cost of GnRH agonist treatment for endometriosis by using non-standard dosing regimens?An extended-interval dosing regimen of a 3.75 mg depot formulation of triptorelin injected every 6 weeks instead of every 4 weeks reduces the cost by one-third without compro...

Driancourt MA, Briggs JR

At present, only surgical sterilization is available for veterinarians and pet owners seeking suppression of fertility in male dogs, in most countries. An alternative contraceptive alternative approach is GnRH releasing implants that desensitize the pituitary to the stimulatory effects of GnRH an...

Avdeef A, Kansy M

This study describes a novel nonlinear variant of the well-known Yalkowsky general solubility equation (GSE). The modified equation can be trained with small molecules, mostly from the Lipinski Rule of 5 (Ro5) chemical space, to predict the intrinsic aqueous solubility, S0, of large molecules (MW...

Bar Hava I, Yafee H, Omer Y, Humaidan P, Ganer Herman H

We aimed to explore whether ovulation induced by a GnRH analogue (GnRHa), followed by daily GnRHa luteal support provides an efficient platform for natural cycle frozen embryo transfer (NC-FET). In this cohort study, included were normo-ovulatory women who underwent NC-FET cycles, under the age o...

Chatterjee S, Maity A, Chowdhury S, Islam MA, Muttinini RK, Sen D et al.

The recent outbreak of the 2019 novel coronavirus disease (COVID-19) has been proved as a global threat. No particular drug or vaccine has not yet been discovered which may act specifically against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and causes COVID-19. For this highly i...

Kwok KY, Choi TLS, Kwok WH, Lau MY, Leung EMK, Leung GNW et al.

The use of bioactive peptides as a doping agent in both human and animal sports has become increasingly popular in recent years. As such, methods to control the misuse of bioactive peptides in equine sports have received attention. This paper describes a sensitive accurate mass method for the det...

Lobach VN, Casalechi M, Dela Cruz C, Pereira MT, Del Puerto HL, Reis FM et al.

Granulosa cells control oocyte maturation through paracrine signalling and changes to the microenvironment around the oocyte. Apoptosis occurs as a physiological mechanism of granulosa cell renewal, but how it relates with the ovarian response to induced ovulation is still unclear. Therefore, thi...

Alizadeh B, Bahari Javan N, Akbari Javar H, Khoshayand MR, Dorkoosh F

The principal purpose of the present study was to prepare and characterize a complex drug delivery system consisting of Nafarelin-poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanoparticles (NPs) in combination with sodium alginate/poloxamer 407 in situ gel. Nafarelin-loaded PHBV NPs were ...

Bar-Hava I, Mizrachi Y, Karfunkel-Doron D, Omer Y, Sheena L, Carmon N et al.

To study whether intranasal GnRH agonist (GnRHa) can be effectively used for luteal support in high-responder patients undergoing fresh-embryo transfer after ovulation induction with the use of GnRHa.Retrospective cohort study.Private fertility clinic.Forty-six high-responder patients were admini...

Lahav-Baratz S, Koifman M, Sabo E, Auslender R, Dirnfeld M

This preliminary study examined a possible effect of long duration repeated hormonal stimulation on the endometrium using a molecular tool. The expression of the hormone stimulated, cell cycle regulators, p27 and its ligase S-phase kinase-interacting protein2 (Skp2), were assessed in 46 endometri...

Wang J, Yadav V, Smart AL, Tajiri S, Basit AW

This study was the first to investigate the colonic stability of 17 peptide molecules (insulin, calcitonin, glucagon, secretin, somatostatin, desmopressin, oxytocin, Arg-vasopressin, octreotide, ciclosporin, leuprolide, nafarelin, buserelin, histrelin, [D-Ser(4)]-gonadorelin, deslorelin, and gose...

Wang J, Yadav V, Smart AL, Tajiri S, Basit AW

A major barrier to successful oral delivery of peptide and protein molecules is their inherent instability in the lumen of the gastrointestinal tract. The aim of this study was to determine the stability of 17 disparate peptide drugs (insulin, calcitonin, glucagon, secretin, somatostatin, desmopr...