NAD+ Research

Dutta N, Halder N, Chini EN, Kim S, Manna A

The immunosuppressive tumor microenvironment (TME) remains a major barrier to effective cancer immunotherapy. Among the central regulators of immune suppression, CD38, a multifunctional ectoenzyme and surface glycoprotein, has emerged as a pivotal orchestrator. CD38 is abundantly expressed on reg...

Lyu Q, Tan Y, Zeng X, Peng S, Lee M

Diabetic peripheral neuropathy (DPN) is one of the most common chronic complications of diabetes mellitus. The most common type is distal symmetric polyneuropathy, and lesions frequently lead to disabling neuropathic pain and even amputation, increasing the risk of death. At present, the pathogen...

Scudeler CM, da Silva KS, Silva RVN, Micheletti AMR, Ribeiro KB, Machado JR et al.

During tumorigenesis and metastasis, cancer cells initiate antioxidant defense mechanisms to prevent irreversible damage, thereby sustaining tumor growth. The functionality of reactive oxygen species (ROS)-scavenging proteins is dependent on nicotinamide adenine dinucleotide phosphate (NADPH), wh...

Lagartos-Donate MJ, Escobar-Doncel B, Zhang SQ, Pan JP, Villaseca González N, Anisimov A et al.

Downregulation and inactivation of the Repressor Element 1-Silencing Transcription factor (REST) is shown in Alzheimer's disease (AD) and likely contributes to its progression, but the exact molecular mechanism linking REST reduction to AD remains unclear. We examined changes in REST expression i...

Wang J, Ma S, Li S, He S, Wei K, Guo X et al.

Fluorinated liquid crystal monomers (FLCMs), emerging contaminants from electronic waste, exhibit environmental persistence and bioaccumulative potential. Despite their growing detection in humans and aquatic systems, the subcellular mechanisms of their metabolic toxicity remain poorly understood...

Liu J, Cheng Q, Huangfu S, Zhang Y, Jiang B, Zhang Y et al.

Inhibition of NAMPT to reprogram NAD+ metabolism and achieve antitumor activity has become an area of intense interest in cancer metabolism. However, systemic NAMPT inhibition has been hampered by several toxicities due to the ubiquitous requirement of NAD+ in normal tissues. To overcome this lim...

Kang EY, Tseng YJ, Peng WH, Hung HC, Lin PH, Montales KP et al.

Autosomal dominant optic atrophy (ADOA) is a hereditary optic neuropathy caused by OPA1 variants, leading to retinal ganglion cell (RGC) degeneration and vision loss. The mechanisms behind RGC vulnerability to mitochondrial dysfunction remain unclear. We developed a patient-specific Opa1V291D/+ k...

Cuklanz KW, Stein A, Chouinard VA, Ongur D, Du F

Redox dysregulation, characterized by an imbalance in the NAD+ [nicotinamide adenine dinucleotide (oxidized form)]/NADH (reduced form of NAD+) ratio, is implicated in neurodegenerative and psychiatric disorders such as Alzheimer's disease and schizophrenia. This imbalance contributes to mitochond...

Durdu M, Kandemir H, Karakoyun AS, Lysková P, Kolarczyková D, Bingöl O et al.

This study investigated the treatment outcomes of 91 patients with chronic and recalcitrant dermatophytosis from 20 hospitals in Türkiye between June 2022 and March 2024, as well as the in vitro antifungal susceptibility and squalene epoxidase (SQLE) substitution profiles of the dermatophyte...

Bernardo EL, Sales CRG, Sun T, Kromdijk J

Stomata have the crucial role of balancing the uptake of CO2 for photosynthesis and water loss via transpiration by adjusting their aperture. In C3 plants, coordination between photosynthesis and stomatal conductance can be disrupted by mutations in Calvin-Benson-Bassham (CBB) cycle expression, b...

Tang Y, Chen Y, Qi P, Li R, Jiang W, Sun H et al.

Nicotinamide adenine dinucleotide (NAD+) is a key coenzyme for human redox reactions, vital for cellular health and metabolic balance. Lots of NAD+-dependent redox enzymes, like alcohol dehydrogenase (ADH) and lactate dehydrogenase, can catalyze both forward and reverse reactions. However, substr...

Reyna K, Heinzen G, Patel N, Ritter M, Siojo A, Legere H et al.

Nicotinamide adenine dinucleotide (NAD+) is a cofactor for NAD+-dependent enzymes that regulate DNA repair, cellular metabolism, and immune function. Supplementation with NAD+ and its precursors is commonly used to prevent age-related disease and extend healthspan. Commercial clinical and wellnes...

Li R, Cao R, Peng Y, Gan X, Zhang Y, Gu T et al.

Chicken is an important source of protein worldwide, and its quality is influenced by breed, age, and rearing methods. However, how these factors interact at the metabolic level is not fully understood. This study examined Yandang partridge chickens, a native Chinese breed, and commercial Arbor A...

Stott AJ, Bürli RW, Doyle KJ, Dickson L, Hewer RC, Pickford P et al.

Cluster of differentiation 38 (CD38) is a nicotinamide adenine dinucleotide (NAD+)-consuming ectoenzyme abundantly expressed in brain regions involved in motor control and cognition. Given the central role of NAD+ in maintaining neuronal health, inhibition of CD38, resulting in NAD+ elevation, ha...

Veliova M, Ferreira CM, Montales KP, Villalobos F, Brownstein AJ, Acín-Pérez R et al.

Brown adipose tissue (BAT) plays a central role in thermogenesis by coupling fatty acid oxidation to heat production. Efficient BAT thermogenic activity requires enhanced glycolytic flux, which in turn depends on continuous regeneration of cytosolic NAD+ to sustain glyceraldehyde-3-phosphate dehy...

Lebedeva NA, Maltseva EA, Rechkunova NI, Lavrik OI

DNA damage repair by the base excision repair (BER) mechanism is a complex, multistage process that requires precise coordination and regulation of activities of enzymes at each step of DNA repair. The central stage in this process is DNA synthesis in the gap formed by removal of the damaged...

Moscarelli M, Skeffington KL, Fudulu D, Punjabi P, Emanueli C, Fiorentino F et al.

Effective myocardial protection during cardiac surgery is essential, yet the differential metabolic stress of the left (LV) and right ventricles (RV) to ischemia-reperfusion remains poorly characterized.This predefined substudy of a multicenter randomized trial conducted in the United Kingdom (IS...

Sutyak KM, Chen EC, Mock L, Cabrera R, Joly JM, Tsao K et al.

Prehospital blood transfusion improves mortality in adults, with limited evidence in children. This study describes prehospital blood transfusion in pediatric trauma patients and the impact on shock index, pediatric adjusted (SIPA).This study is a retrospective cohort study of trauma patients you...

Vinten KT, Schomakers BV, Denis S, van Weeghel M, Jongejan A, Ofman R et al.

Nicotinamide adenine dinucleotide (NAD+) is a vital molecule, serving as a redox cofactor and the limiting substrate for numerous enzymes. NAD+ decline is a key feature of aging, while supplementation with NAD+ precursors can efficiently counteract aging traits and prevent age-associated conditio...

Zhong Z, Liu H, Wu Q, Cao B, Peng Y, Liu M et al.

Metallodrug-induced immunogenicity offers significant potential for improving the efficacy of cancer immunotherapy with metals such as gold serving as a notable example. However, heavy metals may concurrently disrupt immune cell function, and a few of them can augment immunogenicity without compr...