Myristoyl Pentapeptide-17 Research

Institute for Quality and Efficiency in Health Care (IQWiG)

The aim of this report is to: assess the benefit of diagnostics using cardiac magnetic resonance imaging as part of a diagnostic strategy, compared with a diagnostic strategy without cardiac magnetic resonance imaging, in terms of patient-relevant outcomes. These diagnostics should be used as fur...

Hart LN, Errera R, Godwin C, Loftin KA, Laughrey ZR, Katona LR et al.

Toxic cyanobacterial harmful algal blooms (cyanoHABs) threaten freshwater resources globally and are intensifying with increasing eutrophication. Bloom toxicity is strongly influenced by intraspecific variation in the biosynthetic repertoires of toxic cyanobacteria, yet few studies examine the di...

de Oliveira Carvalho J, Cortat PR, Covre AB, Sartori R, Dode MAN

Fertility in mammals is influenced by the interaction between spermatozoa and the female reproductive tract. While sperm has traditionally been regarded as passive carriers of paternal DNA, there is growing evidence that they actively influence the oviductal environment. In cattle and other speci...

Taruta H, Tanaka T, Kaneko MK, Suzuki H, Kato Y

The CXC chemokine receptor 2 (CXCR2) is a member of the G-protein-coupled receptor superfamily and regulates a diverse range of immune responses and tumor progression. CXCR2 is expressed on immune cells, especially neutrophils, and is involved in various immune responses by interacting with its c...

Soucek DJ, Dorman RA, Candrl JS, Moody AH, Lane RF, Greer JB et al.

Studies of 6PPD-quinone (6PPDQ) toxicity have identified both sensitive and resistant salmonid species at environmentally relevant concentrations. However, comparisons between species are complicated by varying testing conditions, which can limit the application to derivation of environmental qua...

Wang D, Liu Y, Zeng YH, Jiang XD, Cui WH, Suo ZQ et al.

Rose represents the most traded cut flowers worldwide with enormous diversity in floral organs, especially petal number, a target trait during modern rose breeding. With a detailed phenome analysis, we here report the high variation pattern in floral organ number among 132 rose lines, including w...

Trabelsi B, Baccouche H, Chakroun A, Mahjoub S

Clot Waveform Analysis (CWA) has been studied in bleeding disorders but remains poorly explored in thrombotic conditions. The aim was to evaluate the performance of CWA parameters for detecting hypercoagulability in venous thrombosis. A study was conducted in 2023 at the hematology laboratory of ...

Chakraborty A, Roy S

Solvation dynamics play a central role in shaping nucleic acid structure, flexibility, and recognition, yet their molecular origins remain poorly understood for RNA, whose diverse architectures and intrinsic conformational plasticity far exceed those of DNA. Here, we present the atomistic, micros...

Liu M, Li W, Ji Y, Chen Y, Wei G, Huo J et al.

Colorectal cancer is a leading cause of cancer mortality characterised by a unique metabolic microenvironment and complex interactions with the gut microbiota. Lactylation, a novel post-translational modification derived from lactate, has emerged as a key epigenetic regulator connecting metabolic...

Wei J, Wang X, Xian J, Siddique F, Hou S, He T et al.

Xanthomonas citri subsp. citri (Xcc), the pathogen responsible for citrus canker, causes major economic damage worldwide. The type III secretion system (T3SS) is essential for Xcc pathogenicity. Here, 39 chiral 1,3,4-oxadiazole sulfide derivatives of mandelic acid were synthesized, with 17 compou...

Karia CT, Singh G, Bourke G

Innovation drives progress in hand surgery, yet long-term technological trends are rarely quantified. Patent filings provide a record of commercial and research activity and can be used to examine how innovation evolves over time. This study aims to provide a overview of long-term overview of inn...

Haugen HJ, Sanz J, Perale G, Saiz AM, Romandini M, Rahmati M et al.

Bone substitute biomaterials have become a sine qua non in periodontology and implant dentistry; however, the ideal material choice remains controversial. In this review, we examine natural grafts (autograft, allograft, xenograft) and synthetic grafts (alloplasts, composites, CAD-CAM personalised...

Papa A, Balzan S, Lubrano V, Sabatino L

Atherosclerosis and diabetes are largely recognized as inflammatory disorders underlying cardiovascular disease. C-reactive protein, interleukin-6 and fibrinogen constitute the most established inflammatory biomarkers in clinical practice for the characterization of individuals affected by athero...

Wilson KJ, Esteban-Lopez M, Myhr C, Ye W, Moore CE, Southall N et al.

A dose-response quantitative high-throughput screening of 147,334 small molecule compounds using a human Relaxin/Insulin-like Family Peptide Receptor 2 (RXFP2)-transfected HEK293T-RXFP2 cell line identified compound 5 with modest Insulin-Like3 (INSL3) agonist activity. An extensive structure-acti...

Rouse J, Rouse C, Liu H

In Monte Carlo simulations of electron sources, random initial conditions of the particles' velocity components at the cathode need to be generated: these velocities are governed by the initial energy and angular distribution of the source. To generate the distributions numerically, the probabili...

Pramanik A, Rani R, Jha B, Pramanik DD, Mishra P

Targeted delivery of chemotherapeutic agents can reduce systemic toxicity and enhance therapeutic outcomes by increasing the level of drug accumulation at tumor sites. In this study, we developed lipid-based cubosomal nanocarriers with an optimal size of 157 ± 20 nm for effective tumor penet...

Hughes S, Cheong J, Snape J, Jethwa S, Ng SH, Thangarajah R et al.

Teicoplanin exhibits complex pharmacokinetics with substantial inter-patient variability. Therapeutic drug monitoring (TDM) is recommended to ensure adequate exposure, yet contemporary data on real-world prescribing practices are scarce. We evaluated current teicoplanin dosing and monitoring prac...

Ciornei ȘG

This article presents an overview of the update on direct embryo transfer using hatched blastocysts. Recent research has observed differences in conception rates in sheep following surgical transfer. All sessions included in the study followed the same standard protocol, resulting in the creation...

Weindorf N, Rapsch T, van Berkel WJH, Tischler D

Flavoenzymes of the 4-phenol oxidoreductase family are versatile biocatalysts that catalyze the oxidation of a wide variety of phenol derivatives to alcohols, aldehydes, ketones or alkenes. The promiscuous FAD-dependent vanillyl alcohol oxidases from Penicillium simplicissimum (PsVAO) and Diplodi...