MOTS-c Research

Li Z, Wang T, Fu Y, Chen F, Li S

Myocardial fibrosis stands as a defining pathological characteristic in type 2 diabetes. Aerobic exercise curbs the overproduction of type I/III collagen and boosts matrix metalloproteinases, thereby improving outcomes related to fibrosis in the heart. Although physical activity is well known for...

Güvenir Seven S, Sahin H, Erkanlı Şentürk G, Uysal N, Uzun H, Ekici O et al.

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired social interaction and repetitive behaviors, with currently limited therapeutic options. Oxidative stress is suggested as significant in ASD pathophysiology, making antioxidant strategies a promising therape...

Kutuk IS, Akin S, Demirel H, Mumusoglu S, Ciftci T, Yildiz BO et al.

Feng Z, Xing Y, Lou J, Li H, Zhang Z, Li M et al.

Prolonged exposure to high altitude (HA) results in a range of systemic changes, some of which, specifically for the heart, particularly cardiac changes, remain difficult to reverse after returning to low altitude. Cardiac de-acclimatization after HA exposure and its underlying mechanisms remain ...

Santhanam SS, Jayaraman S, Kurian GA

The mitochondrial-derived peptide MOTS-c regulates metabolic and cellular stress responses, but its dose-response profile and direct cardioprotective mechanisms in myocardial ischemia-reperfusion injury (MIRI) remain undefined. This proof-of-concept study aimed to identify the optimal cardioprote...

Kannan HT, Pan I

Hepatocellular carcinoma (HCC), the most common primary liver cancer, is characterized by late diagnosis, limited treatment efficacy, and a highly immunosuppressive tumour microenvironment. Chronic liver injury, fibrosis, and inflammation are central to HCC pathogenesis, leading to genetic and ep...

Behan M, Yen K, Cohen P, Kliment CR

As bioactive microproteins, mitochondrial-derived microproteins (MDPs) are encoded within the small open reading frames of mitochondrial DNA. MDPs have been shown to be altered in a number of disease states and have mitochondrial, nuclear, and extracellular actions. Most published work on MDPs ha...

Yoon SH, Yuan F, Zhu X, Tang H, Abdurakhimoova D, Krier J et al.

MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c) is a mitochondrial-derived peptide and regulator of metabolic homeostasis. Although its role in glucose and lipid metabolism is emerging, changes in circulating MOTS-c with obesity remain unclear. We hypothesized that circulating MO...

Thoudam T, Zeng G, Gao H, Jiang Y, Huda N, Yang Z et al.

Mitochondria-derived peptides (MDPs) are bioactive molecules encoded by small open reading frames within mitochondrial DNA (mtDNA). Humanin, the first MDP to be discovered, functions as a cytoprotective factor, protecting cells from stress-induced apoptosis. Subsequent discoveries expanded this f...

Gudiksen A, Hansen CC, van der Stede T, Daugaard AH, Schmidt JH, Ringholm S et al.

Mitochondrial-derived peptides are a small class of regulatory peptides encoded by short open reading frames in mitochondrial DNA. One such peptide, mitochondrial open reading frame of the 12S rRNA-c (MOTS-c), has been shown to exert numerous beneficial effects on whole-cell and systemic metaboli...

Erol V, Avci E, Kabukcu Hacioglu S, Guler N, Akgun Cagliyan G, Ünver Koluman B et al.

This study evaluated whether serum levels of mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) could provide prognostic insights in patients newly diagnosed with multiple myeloma (MM), particularly in relation to therapeutic responsiveness.In a prospective analysis involving 29 MM patie...

Hu S, Hu C, Tong M

Mitochondrial-derived microproteins (MDPs) translate mitochondrial stress into cellular decisions that shape aging, metabolism, cancer biology, and neurodegeneration. Humanin, MOTS-c, SHLPs, and the recently identified SHMOOSE act through distinct intracellular and receptor-mediated pathways to r...

Liu Z, Shen Z, Lu H, Lu B, Zhang P, Chen W et al.

Sarcopenia, a progressive skeletal muscle disorder marked by loss of mass and function, presents growing societal challenges due to limited therapeutic options. Here, we identify mitochondrial dysfunction and oxidative stress as central drivers of sarcopenia through integrated bioinformatics and ...

Cao P, Wang B, Zhang N, Yang J, Tong Q, Gong Z et al.

To date, the role of MOTS-c (mitochondrial open reading frame of the 12S ribosomal RNA type-c) in acute coronary syndrome remains largely unknown. We measured circulating MOTS-c levels, markers of oxidative stress, and blood biochemical parameters in patients with acute coronary syndrome and exam...

Rodríguez-Esparragón F, Cazorla-Rivero SE, Torrealba E, Cánovas-Molina Á, González-Hernández AN, Martín-Alfaro R et al.

Humanin (HN) and MOTS-c are mitochondrial-derived peptides (MDPs) known for their neuroprotective and metabolic functions. Their circulating and tissue levels decline with age and in neurodegenerative diseases such as Alzheimer's disease (AD). This study aimed to evaluate whether blood and plasma...

Chen D, Zhao HM, Sun XL, Xing ZX, Li SP, Li SC et al.

Intrauterine growth restriction (IUGR) is a leading cause of perinatal morbidity and mortality. Oxidative stress is a key factor in the pathogenesis of IUGR. The transcription factor nuclear factor erythroid 2‑related factor 2 (Nrf2) is a key regulator of the cellular antioxidant response....

Fang T, Han JC, Taberner A, Pham T

Diabetes mellitus is a major global health issue with complex aetiology and a higher risk of consequent health complications. Advances in research and knowledge prompt new therapies to focus beyond glycemic control to include organ-protective therapies better optimise treatment outcomes. MOTS-c, ...

Li K, Yang T, Chen F, Lou C, Chen Y, Chen Z et al.

Osteoarthritis, a common chronic degenerative disease in the field of orthopedics, is caused by the interaction of mechanical stress, traumatic inflammation, and metabolic imbalance, and this interaction progresses over time. MOTS-c, a mitochondria-derived peptide, exerts pivotal roles in regulat...

Ozkaya DY, Haymana C, Demirci I, Duman UG, Küpçük E, Koç GE et al.

To investigate the Mitochondrial Open Reading Frame of the 12S rRNA type-c (MOTS-c) peptide levels in individuals with obesity compared to those with a normal body mass index and to examine the association of MOTS-c levels with markers of insulin resistance, endothelial function, and inflammation...

Tero-Vescan A, Degens H, Matsakas A, Ștefănescu R, Ősz BE, Slevin M et al.

Regular physical activity induces a dynamic crosstalk between skeletal muscle and adipose tissue, modulating the key molecular pathways that underlie metabolic flexibility, mitochondrial function, and inflammation. This review highlights the role of myokines and adipokines-particularly IL-6, iris...