Motilin Research

Podolanczuk AJ, Mulder H, Kim JS, Neely ML, Kaner RJ, Todd JL et al.

Chen XX, Han XF, Chu Y

Cerebral infarction (CI) is a major subtype of ischemic stroke, with high incidence, recurrence rate, disability rate, and mortality rate in the elderly. Elderly CI patients are prone to peptic ulcer due to long-term use of antiplatelet drugs and stress factors, which further leads to gastrointes...

Estofolete CF, Saivish MV, Nogueira ML, Vasilakis N

Dengue continues to pose a significant global health threat. However, the development of a safe and effective tetravalent vaccine is impeded by complex serotype-specific and cross-reactive immune responses. This review assesses licensed and advanced dengue vaccines, emphasizing serostatus-depende...

Milojevic M, Serruys PW

Zhang Y, Ru A, Wang X, Wang K, Bai X, Zhang X et al.

Beef and yam are valued as functional foods, yet their synergistic effects on gastrointestinal health and immunity remain underexplored. This study investigated the effects of beef and yam on the spleen and stomach. In the present study, a rat model of spleen deficiency was established by poor di...

Zanco C, Mondellini M, Nicora ML, Malosio M, Tauro G, Rizzo G et al.

Patient engagement and mental workload (MWL) are often overlooked when optimising robotic-assisted rehabilitation, despite their potential impact on its effectiveness. This study aims to propose a multimodal approach to assess MWL and engagement, using electrophysiological signals and questionnai...

Song Y, Mehl F, No T, Livingston L, Quintero Barbosa JS, Hayashi J et al.

Many people are affected by post-acute sequelae of COVID-19 (PASC/long COVID, LC). LC has severely affected public health. Features of LC including blood pressure dysregulation, coagulopathies, hyperinflammation, and neuropsychiatric complaints. Mechanisms responsible for LC pathogenesis are not ...

Takahashi S, Inoue T, Ensbey KS, Legg SR, Sekiguchi T, Nelson EL et al.

Acute graft-versus-host disease (GVHD) of the gastrointestinal (GI) tract is a primary cause of early transplant mortality after bone marrow transplantation (BMT), driven by local antigen presentation and T-cell expansion. We sought to clarify the role of various donor dendritic cell (DC) subsets...

Hitchings MDT, Huang AT, Ranzani OT, García-Carreras B, Nogueira ML, Ko AI et al.

Infants represent a vulnerable population for severe outcomes from infectious diseases. For dengue virus, maternal antibodies can cause severe disease in infants aged 5-12 months through antibody-dependent enhancement, but the role of maternal immunity in neonates aged 0-30 days has not been quan...

Rose D, Moreno R, Osman H, Rowland M, Silverman J, Ciernia A et al.

Autism spectrum disorder (ASD) is characterized by atypical communication, social interactions, and restricted interests. In ASD, there are dysfunctional immune regulatory control mechanisms that can lead to immune activation. Notably lower frequencies of regulatory T cells (Tregs) and reduced im...

Ammirati E, Palazzini M, Lehtonen J, Potena L, Mäyränpää MI, Rågback J et al.

No large registries of patients with acute eosinophilic myocarditis (EM) are available. However, EM is perceived as a cardiac disease with high mortality, affecting mainly young and middle-aged adults according to small series and case reports. Awareness of the clinical presentation, associated s...

Johnston WR, Giannotti A, Hwang R, Allukian M, Nance ML, Nace G et al.

Recovery from pediatric injury frequently requires transfer to an inpatient rehabilitation facility (IRF) for further convalescence. Waiting for disposition to such facilities can substantially prolong hospitalization. This study sought to determine the root causes of delayed discharge following ...

Faria CS, Baldavira CM, Prieto TG, Santoro IL, Figueiredo VR, do Nascimento ECT et al.

Histopathological evaluation, TNM classification, and mediastinal staging via endobronchial ultrasound-guided transbronchial needle aspiration provide essential guidance for therapeutic decision-making in non-small cell lung cancer (NSCLC). Genomic profiles of primary tumors (PT) and matched medi...

Wang R, Goruk S, Chan CB, Field CJ

Long-chain polyunsaturated fatty acids (LCPUFA) promote immune development and improve obesity-related inflammation. This study determined the effects of LCPUFA-supplemented diets (age Wk3-10) fed to male and female rats on: 1) anthropometrics and glucose tolerance, 2) splenocyte membrane lipid c...

Xia P, Shuang S, Fu D, Liu L, Yang D, Guo Y et al.

The extensive intratumoral and microenvironmental heterogeneity of hepatocellular carcinoma (HCC) remains a major therapeutic barrier. Integrating single-cell transcriptomics samples spanning normal liver, primary tumors, portal vein tumor thrombus (PVTT), and metastatic lymph nodes (MLN) with sp...

Feng C, Chen G, Shu Y, Chen J, Ye W, Ren L et al.

Given the high recurrence rate of bladder cancer (BCa) and the significant adverse effects associated with conventional treatments, it is urgent to search for new clinical therapeutic targets and safer natural-derived compounds. Resveratrol (Res) has been demonstrated to exhibit cytotoxicity agai...

Yasumitsu T, Yagita Y, Fujiki Y, Tamura S

Pex14 is a membrane peroxin that plays a central role in matrix protein import by mediating the docking of the cytosolic receptor Pex5, which delivers cargo harboring a peroxisome targeting signal 1. We previously reported the crystal structure of the conserved N-terminal domain of Pex14, which h...

Shan Y, Liu X, Ma W, Qu Y, Bian C

Constipation has emerged as an important public health concern, and novel therapeutic approaches, such as those, are attracting increasing attention. However, the effects and mechanisms of Bifidobacterium breve (B. breve) and Lacto-N-neotetraose (LNnT) in relieving constipation remain incompletel...

Pathak BK, Maurya M, Mishra N, Yadav RK, Singh A, Sonkar M et al.

Microcytic hypochromic anemia is common in severe acute malnutrition (SAM) children, but macrocytic anemia (vitamin B12/folate deficiency) is not uncommon. Vitamin B12 deficiency leads to anemia and developmental slowing. We looked for the response of vitamin B12 supplementation on hematological ...

Zhou H, Xie H, Chen S, Li H, Liu S, Luo M et al.

An accurate assessment of metastatic lymph nodes (MLNs) in head and neck magnetic resonance imaging (MRIs) is crucial in nasopharyngeal carcinoma (NPC) staging and treatment planning. As a fundamental step in computer-aided diagnosis systems, automated MLNs segmentation remains challenging due to...