Melittin Research

Li D, Xue F, Wu Y, Chang L, Song Y, Du X et al.

Paclitaxel-induced peripheral neuropathy is a leading cause of premature discontinuation of taxane-based chemotherapeutic regimens. Studies have affirmed the analgesic properties of bee venom-containing pharmacoacupuncture, demonstrating that anti-nociceptive effects occur following melittin trea...

Tang L, Li Y, Lv X, Guo J, Zhang Y, Lin Y et al.

Antimicrobial peptides (AMPs) hold promise as anticancer agents but suffer from proteolytic instability, systemic toxicity, and hemolysis. Here, we report a modular redox-responsive polymeric nanocapsule platform for enhanced tumor-targeted AMP delivery. Using melittin (MEL) as a stringent model,...

Wang Y, Yu Y, Wang S, Qu J, Song Y

Natural killer (NK) cells are pivotal effector cells of the innate immune system. Their capacity to recognize and eliminate malignant cells without requiring antigen priming has attracted considerable interest in tumor immunotherapy. While NK cell therapy has shown relatively consistent clinical ...

Ehlert ME, Ferreira VG, Pacheco BS, Souza FSS, Tisoco I, Almeida Iglesias B et al.

Melanoma occurs in both humans and dogs, reinforcing the importance of comparative oncology, and photodynamic therapy (PDT) stands out as a promising, minimally invasive and selective treatment strategy. In this study, we evaluate the photodynamic effects of palladium(II)-complexed meso-tetra-cat...

Aagaard JB, Gandini R, Ballegaard AR, Jensen BK, Dorn B, Larsen AVB et al.

Insect venoms can cause severe allergic reactions, including anaphylaxis, in sensitized individuals. In this study, we aim at preventing anaphylaxis mediated by the most abundant and dominant honeybee venom allergen phospholipase A2 (Api m 1) by blocking its interaction with allergic patient IgE....

de Mel RK, Baloun DE, Baniya S, Cabral de Mel SJ, Czenze ZJ

Despite the threat of global warming, few studies have investigated inter- and intra-specific thermoregulatory variation in bats at high temperatures. Those from Europe and Africa suggest that individuals from warmer roosts tolerate higher temperatures than those from comparatively cooler roosts....

Shi Y, Teng C, Chen J, Zhou Y, Wu M, Xu K et al.

The widespread use of melamine (MEL) and its derivatives has resulted in pervasive human exposure, yet their transplacental transfer and developmental consequences remain insufficiently characterized. In a mother-infant cohort, we quantified four MEL derivatives in matched maternal urine (median:...

Hacımustafaoğlu F, Aras S, Erzurumlu Y, Peran BC

This study aims to investigate the radioprotective effects of melatonin (MEL) against oxidative damage that may be caused by flattening filter (FF) and flattening filter-free (FFF) beam in the cerebrum and cerebellum of rat using various genetic markers. Forty female Wistar albino rats were rando...

de Sousa MHO, Freitas MSD, Cesca K, de Moura NF

Cunila angustifolia ("vassourinha do campo") is a plant species native to southern Brazil that is traditionally consumed as an herbal infusion. In the present study, the hydroethanolic extract of C. angustifolia leaves, its solvent-partitioned fractions, and the flavonoids acacetin and acacetin-7...

Hosain R, Michael YL, Wallace RB, Chlebowski RT, Garcia DO, Nassir R et al.

Lung cancer remains the foremost cause of cancer mortality among US women, with a notable proportion arising in never-smokers. While occupational exposures contribute to lung cancer risk, women have been underrepresented in occupational studies. Therefore, we examined the relationship between occ...

Zeng X, Zhang D, Chen S, Huang X, Zhao Z, Li X et al.

Rapid and accurate detection of bioactive phenolic compounds in food is crucial for assessing nutritional value and ensuring quality. Gallic acid (GA) is a naturally occurring polyphenolic compound found in plant-based foods such as grapes, mangoes, and tea leaves. It possesses significant antiox...

Osama J, El-Gazar AA, Ragab GM, El-Sayed NS, Kamel AS

Fibromyalgia (FM) is a central sensitization syndrome characterized by neuroinflammation and synaptic hyperexcitability, which amplifies pain signals in the spinal cord (SC) and dorsal root ganglia (DRG). Melatonin (MEL) has demonstrated analgesic and antinociceptive properties in experimental mo...

Fiji M, Yan S, Kumar P, Schwalbe-Koda D, Rimer JD

The design of next-generation materials for emerging energy and environmental applications heavily relies on empirical approaches to direct nonclassical nucleation and crystal growth pathways, polymorphism, intercrystalline transformations, and seed-assisted growth processes. A long-standing obst...

Ríos-Urrego CD, Ruiz-Romero TA, Puerta-Lotero D, Escobar-Grisales D, Orozco-Arroyave JR

Background: Parkinson's disease (PD) is a neurodegenerative disorder that affects millions of people worldwide. Speech analysis has emerged as a non-invasive tool for automatic PD detection; however, the scarcity and homogeneity of available datasets often limit the generalization capability of m...

Tasca S, Türck P, Drosdowski D, Campos Carraro C, Belló-Klein A, Luz de Castro A et al.

Pulmonary artery hypertension (PAH) is characterized by increased pulmonary vascular resistance, leading to the augmented afterload of the right ventricle (RV), hypertrophy, and heart failure. Oxidative stress and inflammation in the RV may be involved in the physiopathology of PAH. Because of th...

Ando H, Reynolds K

Left-censored data (i.e., microbial non-detection data) in wastewater surveillance hinder accurate understanding of disease incidence and the early detection of epidemic signals in the initial stages. In this study, we propose state-space models incorporating a logistic model to handle left-censo...

Onilov O, Visser L, Biernat A, Lawe-Davies O, O' Connor L, Chriscaden K et al.

Emergency risk communication is an integral component of an emergency response, including to the coronavirus disease pandemic. Designing and implementing effective communication, particularly in the context of new, evolving public health crises, requires systematic measurement, evaluation, and le...

Downs EM, Perito ER, Wang F, Cress GA, Abu-El-Haija M, Chugh A et al.

Acute recurrent pancreatitis (ARP) in childhood can rapidly progress to chronic pancreatitis (CP). Prospectively-collected data from the INternational Study group of Pediatric Pancreatitis: In search for a cuRE (INSPPIRE) provides novel insight into disease progression.INSPPIRE subjects were cate...

Longaretti LM, Magenis ML, Damiani AP, da Luz Beretta ÂC, de Oliveira Monteiro I, Possamai OL et al.

Overweight and obesity have been increasing drastically in recent years due to the growing consumption of fast food. Obese individuals exhibit reduced antioxidant defenses, which can lead to DNA damage. Thus, studies have been conducted to mitigate obesity-related complications. Animal research h...

Monetathchi AR, Carson WO, Upshaw B, Lester A, Cleary E, Little A et al.

Despite a decline in colorectal cancer (CRC) incidence and mortality for the general United States population, American Indian/Alaska Native (AI/AN) populations have seen an increase in both measures. AI/AN populations have also experienced the largest increase in early-onset colorectal cancer, h...