Melanotan II Research

Kovanur Sampath K, McIntyre C, Arumugam A, Thomson OP, Andersen P

Three-dimensional (3D) technologies such as virtual reality (VR) may facilitate the teaching and learning of manual therapy (MT). Teachers play a pivotal role in determining how new tools and technology are adopted and applied in the curriculum. Moreover, educators' feedback can guide the develop...

Nakano D, Kozako T, Ishitsuka K, Kurasono C, Tsuchihashi R, Nohara T et al.

Adult T-cell leukaemia/lymphoma (ATL) is a malignancy of mature peripheral T-lymphocytes caused by human T-cell lymphotropic virus type I (HTLV-I). Administering conventional chemotherapeutic regimens used against malignant lymphomas to patients with ATL results in poor therapeutic outcomes. Prev...

Agyapong W, Weber N, Waleczek FJG, Neumann K, Neumüller S, Möllmann M et al.

Viperid snake venoms contain a group of cytotoxic proteins called Lys49 phospholipase A2 (PLA2)-like myotoxins. These proteins lack enzymatic activity, but can still disrupt the sarcolemma and induce cell death. On skeletal and cardiac muscle, PLA2-like myotoxins induce substantial alterations to...

Lepailleur A, Geslin D, Giovannini J, Cuissart B, Lamotte JL, Bureau R et al.

Understanding ligand selectivity and efficacy at melatonin (MT1, MT2) and serotonin (5-HT2C) receptors remains a key challenge in central nervous system (CNS) drug discovery. Ligands combining MT1/MT2 agonism with 5-HT2C antagonism are of therapeutic relevance in depression and circadian rhythm d...

Qiu X, Liu H, Song P, Cheng X, Wu W, He S et al.

Engineering protein thermostability is a key aspect of rational protein design, aiming to broaden the applicability of enzymes and enhance their industrial utility. In this study, we introduce a strategy for identifying and reinforcing dynamic stability centers of local structure (DSCLSs) to impr...

Kantola KG, Wynn R, Johnsen JK, Hadler-Olsen E

This study examined caries experience and its association with demographic, socioeconomic, and psychometric factors among persons with severe psychiatric and/or substance use disorders.A cross-sectional study was conducted among inpatients at the Division of Mental Health and Substance Use, Unive...

Chakraborty N, Pal S, Das A, Roy S, Adak MK, Fayezizadeh MR et al.

Melatonin (MT) and selenium (Se) are quite known in application in regulation of abiotic stress tolerance where metals remain important. Undoubtedly, MT being a signalling molecule and Se, a multivalent metalloid have been effective in metal stress alleviation individually, however, a limitation ...

Zhang SJ, Geng MM, Li QW, Li XH, Zhou Y, Luo LF et al.

The Koebner phenomenon is a hallmark of active vitiligo, yet its underlying mechanisms remain unclear. Here, we investigated whether calcitonin gene-related peptide (CGRP), which is released from transient receptor potential vanilloid 1 (TRPV1)+ nociceptive neurons following skin injury, impairs ...

Bedini A, Galvani F, Elisi GM, Scalvini L, Mari M, Recchia A et al.

Tetrahydroquinoline (THQ) derivatives bearing an N-acylaminoethyl side chain were investigated as a new class of potent melatonergic ligands offering opportunities for a versatile modulation of binding and pharmacological properties. These compounds were designed from N-anilinoethylamide ligands ...

Li S, Xu K, Wang A, Qin C, Hua N, Ling X et al.

Ultrasound is a promising tool for diagnosing sarcopenia, yet standardized cut-off points and criteria are currently lacking. This study aimed to identify the optimal muscle sites and reference values for diagnosing low muscle mass in older Chinese adults using ultrasound, with dual-energy X-ray ...

Heymann CJF, Gouwy M, Hermans R, Twizere JC, Assone T, Casseb J et al.

Human T-lymphotropic virus type 1 (HTLV-1) infects up to ten million people worldwide, and causes severe diseases, including adult T-cell leukemia/lymphoma and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Individuals with HAM/TSP are prone to pulmonary complications (e.g.,...

Kala U, Desai JR, Majumdar B, Pradhan A, Thounaojam S, Sen A et al.

To highlight the role of multicolor imaging to differentiate between the two cases presented, macular telangiectasia type 2 (MT 2) and tamoxifen retinopathy (TR) which have very similar phenotypical properties and can often present a diagnostic dilemma.Retrospective analysis of 2 cases, MT 2 and ...

Ríos-Osorio N, Orozco-Agudelo M, Cespedes-Moreno I, Contreras-Ibarra M, Guerrero-Torres M, Castro-Calderón A et al.

This systematic review compares xenogeneic collagen matrices (XCMs) and autogenous graft-based techniques, focusing on 1) the effectiveness of XCMs (non-crosslinked XCM [XCM*] and crosslinked XCM [VCMX]) vs. connective tissue graft (CTG) for increasing buccal mucosal thickness (MT), and 2) the ef...

Buizastrow J, Roque-Torres GD, Handysides R, Gray R, Noorvash S, Oyoyo U et al.

To evaluate whether maxillary sinus mucosal thickening (MT) observed on cone-beam computed tomography (CBCT) influences endodontic outcomes, and to identify other radiographic predictors of healing.This retrospective cohort study included cases treated at a graduate endodontic clinic with pretrea...

Chen HH, Kuo YM, Lin YC, Chen YC, Lin GH, Lai YL et al.

This study investigated the impact of sinus membrane thickening and perforation on graft remodeling following osteotome sinus floor elevation (OSFE).A total of 136 patients who received single implants with simultaneous OSFE were retrospectively analyzed and categorized based on preoperative sinu...

Racine J, Ungermann A, Blatter M, von Plato G, Rijkenhuizen ABM

To describe a modified two-portal tenoscopic technique for proximal manica flexoria (MF) resection designed to preserve the mesotendons (MTs) of the deep digital flexor tendon (DDFT).Prospective clinical study.Client-owned horses (n = 30).MF resection was performed in four steps: (1...

Yan X, Tao H, Xu B, Feng R, Zhang B

The aim of this study was to investigate how MF strengths (5 mT and 10 mT) and treatment time (1 h, 2 h, and 3 h) affect gluten protein structures and eventually the oil content of the batter-coated deep-fried pork. The results showed that the stability of the secondary and tertiar...

Feng Y, Liu Y, Ding X, Kang YJ

Alcohol-related liver disease is accompanied by hepatic zinc deficiency. We synthesized a zinc-glutathione (ZnGSH) complex as a zinc delivery system to test the hypothesis that effective zinc supplementation can recover the liver from alcohol-related injury. Mice were fed an ethanol-containing li...

Guimarães AB, Bernardo-Menezes L, Azevedo E, Agrelli A, Silva P, Sena M et al.

Cellular components and inflammatory mediators involved in the transmigration of HTLV-1-infected cells across the blood-brain barrier (BBB) are not fully understood. This study proposes a BBB model to identify the immunological mechanisms associated with HTLV-1 pathogenesis. PBMCs from individual...

Ogbu JI, Moreira CVL, Pereira JKA, da Silva KP, Lião LM, Dietz GPH et al.

Effective restoration of mental health in psychiatric disorders increasingly hinges on bridging neurobiological insights with clinically validated pharmacotherapies. The etiological heterogeneity of anxiety and depression underscores the need for novel compounds capable of modulating multiple neu...