Mecasermin Research

Improda N, Katugampola H, Cerbone M, Shah P, Alexander S, Atterbury A et al.

Donohue syndrome and Rabson-Mendenhall syndrome are extreme forms of insulin resistance caused by biallelic mutations in the insulin receptor gene. Recombinant human IGF1 (rhIGF-1) treatment is often used but its long-term benefits and risks are still poorly delineated. We describe rhIGF-I treatm...

Zheng XZ, Wu L, Chen Q, Lei XF, Guo SL

Ventilator-induced diaphragmatic dysfunction (VIDD) is associated with diaphragm atrophy and decreased contractility, leading to difficult weaning. Respiratory muscle training could prevent diaphragmatic dysfunction. IGF-1 is correlated with the enhancement of muscle mass and strength. The aim of...

Zhu W, Bo W, Ma Y

Myocardial infarction (MI) often induces acute kidney injury (AKI) via systemic hypoperfusion and oxidative stress, yet the protective mechanisms of exercise remain unclear. This study investigated whether intermittent exercise alleviates MI-induced AKI through the insulin-like growth factor-1 (I...

Zhang H, Di M, Wang Y, Ma Y, Gou Y, Zhou Z et al.

Previous studies have shown an association between polycystic ovary syndrome (PCOS) and the use of various medications. However, there is still a lack of systematic research exploring this relationship in depth. This study aims to identify and evaluate drugs that may influence the risk of PCOS us...

Liu H, Liu G, Suo W, Han S, Wang Y, Ding H et al.

3M syndrome is a rare autosomal recessive disorder caused by biallelic pathogenic variants in the cullin 7 (CUL7), obscurin-like 1 (OBSL1), and coiled-coil domain-containing protein 8 (CCDC8) genes and is characterized by pre- and postnatal growth retardation, short stature, dysmorphic facial fea...

Ribeiro FCP, Alves ML, Meneses AC, Silva ÁM, da Silva SZ, Marangoni FK et al.

Mecasermin, a recombinant analogue of insulin‑like growth factor 1 (IGF‑1), is under investigation as a potential therapy for Rett syndrome (RTT), a neurodevelopmental disorder resulting from mutations in the MECP2 gene. In this systematic review, we assessed the impact of mecasermi...

Uçaktürk SA, Özer E, Ceylan AC, Mengen E

Protein glycosylation is a crucial process involving the addition of oligosaccharides to proteins, which plays a significant role in stabilizing proteins and mediating protein-protein interactions. Mutations in genes associated with glycosylation can lead to congenital disorders of glycosylation ...

Chen Z, Li M, Feng Y, Chen Y, Cai Z, Xu Y et al.

This study aimed to investigate the relationship between immunosenescence and osteoarthritis (OA) and analyze its potential clinical implications. Thus, we conducted transcriptome sequencing by collecting clinical meniscus (Aging_meniscus:Control_meniscus = 3:7) and cartilage tissues (Aging_carti...

López-Gambero AJ, Vargas A, Del Mar Fernández-Arjona M, Rubio L, de Ceglia M, Vera-Fernández C et al.

The growth hormone (GH)/insulin-like growth factor (IGF-1) axis determines optimal growth and affects metabolism and energy homeostasis. Pregnancy-associated plasma protein-A2 (PAPPA2) regulates bioactive IGF-1 availability and patients with PAPPA2 deficiency have impaired growth and glucose meta...

Ramon-Krauel M, Polak M, Maghnie M, Woelfle J, Sert C, Perrot V et al.

The Global Increlex® Growth Forum Database (IGFD) Registry monitors real-world effectiveness and safety of recombinant human IGF-1 (rhIGF-1; Increlex® [mecasermin]) treatment in children and adolescents with severe growth failure due to severe primary IGF-I deficiency (SPIGFD).To report...

Ross ML, Kottantharayil SP, Nguyen TK, Ravichandran R, DeForest CA

Though recombinant protein therapeutics hold great potential in treating many diseases, their intravenous delivery introduces challenges with off-target effects and short circulation half-lives. Injectable biomaterial depots have proven useful in confining therapeutic administration to specific b...

Song B, Zhang P, Chen S, Zhang Y, Hu J

Precocious puberty (PP) is the early onset of secondary sexual characteristics before the typical age of puberty, which can be caused by hormonal imbalances or external factors, such as medications. Drug-induced precocious puberty (DIPP) has become a growing concern, particularly in pediatric pop...

Pérez-Revuelta L, Pérez-Boyero D, Pérez-Martín E, Cabedo VL, Téllez de Meneses PG, Weruaga E et al.

In recent decades, the scientific community has faced a major challenge in the search for new therapies that can slow down or alleviate the process of neuronal death that accompanies neurodegenerative diseases. This study aimed to identify an effective therapy using neurotrophic factors to delay ...

Tailor K, van Ree J, Stowe T, Ventura B, Sisk C, Courtis J et al.

Recombinant human IGF-1 is used to treat severe primary IGF-1 deficiency, but this treatment requires twice-daily injection, often does not fully correct the growth deficit, and has important off-target effects. We therefore sought to target IGF-1 to growth plate cartilage by generating fusion pr...

Denaite D, Navardauskaite R

To evaluate the clinical characteristics and treatment efficacy of patients with severe primary IGF-1 deficiency (PSIGFD) using a recombinant IGF-1 (rhIGF-1).To examine the clinical characteristics of patients with PSIGFD before starting treatment with a rIGF-1. To assess the height changes in pa...

Shen J, Liu L, Yang Y, Zhou M, Xu S, Zhang W et al.

Autism spectrum disorder (ASD), a heterogeneous group of neurodevelopmental disorders, is characterized by social impairment and repetitive and stereotypic behaviors. Because of the lack of approved laboratory diagnostic markers and effective therapeutic medications, it is one of the most challen...

Hemmati S, Maghami P, Ranjbari J, Tabarzad M

Insulin-like growth factor-1 (IGF-1) is a single-chain polypeptide with various physiological functions. Escherichia coli is one of the most desirable hosts for recombinant protein production, especially for human proteins whose post-translation modifications are not essential for their bioactivi...

Haridas R, Baxter C, Dover S, Goldbloom EB, Terekhov I, Robinson ME et al.

(1) Background: Severe primary insulin-like growth factor-I deficiency (SPIGFD) is a rare disorder causing short stature in children due to low insulin-like growth factor 1 (IGF-1) levels. Given the sparsity of reported cases of SPIGFD worldwide, the condition may be underdiagnosed, potentially p...

Zhong J, Doughty R, Thymann T, Sangild PT, Nguyen DN, Muk T et al.

Preterm birth disrupts fetal kidney development, potentially leading to postnatal acute kidney injury. Preterm infants are deficient in insulin-like growth factor 1 (IGF-1), a growth factor that stimulates organ development. By utilizing a preterm pig model, this study investigated whether IGF-1 ...

Ekström C, Ortenlöf N, Kristiansson A, Holmqvist B, Jungner Å, Vallius S et al.