Magainin 2 Research

Stepanyan L, Israyelyan M, Gori A, Tsaturyan A, Saribekyan Z, Hovsepyan K et al.

Antimicrobial peptides (AMPs), evolutionarily conserved components of innate immunity characterized by their broad-spectrum efficacy and minimal resistance development, are increasingly recognized as promising therapeutic candidates. This review aims to integrate current knowledge concerning natu...

Zan B, Chen CH, Mateen AI, Kolenovic B, Wiedman GR, Ulmschneider MB et al.

Antimicrobial resistance has emerged as a significant global public health concern, necessitating prompt and comprehensive attention. In response to this pressing challenge, antimicrobial peptides (AMPs), which are innate immune system components naturally synthesized by diverse organisms, hold p...

Yakobi SH, Nwodo UU

Escalating antimicrobial resistance necessitates the development of alternative therapeutics that circumvent conventional enzymatic and efflux-based defence systems. Antimicrobial peptides (AMPs) represent a compelling class of innate immune effectors, however, their clinical translation is hinde...

Li S, Wang K, Shi W, Wang X, Li D, Liu Y et al.

Vancomycin is a critical last-resort treatment for multidrug-resistant Gram-positive bacteria, particularly severe methicillin-resistant S. aureus (MRSA) infections. However, the rise of vancomycin-resistant strains significantly compromises its therapeutic efficacy. To overcome this challenge, r...

Tabarzad M, Torshabi M, Haeri A, Fathi F, Mortazavi SM

Antimicrobial peptides (AMPs) are a prominent weapon that can expand human beings' arsenal against antimicrobial resistance. However, microorganisms can equip themselves against the antimicrobial effects of AMPs. Increasing daily dosing of AMPs to dispel resistance may lead to severe side effects...

Sancho-Vaello E, Kücükyildiz H, Gil-Carton D, Biarnés X, Zeth K

Antimicrobial peptides (AMPs) are ubiquitous weapons of all higher organisms to suppress antimicrobial growth. Despite intensive research, the killing mechanism of these peptides after interaction with the bacterial cell wall and cytoplasm is not well understood. To investigate this mechanism at ...

Nakao H, Maeshiro Y, Ikeda K, Nakano M

Many antimicrobial peptides (AMPs) exert their activity by disrupting the integrity of the bacterial plasma membrane. One of the membrane-disrupting mechanisms of AMPs involves the formation of toroidal pores, composed of α-helices and lipid headgroups. These pores enable the diffusion of l...

Natriashvili A, Mohammadsadeghi N, Smudde E, Berghoff B, Ulbrich MH, Koch HG et al.

Prokaryotic organisms execute multiple stress response mechanisms in order to cope with rapidly changing environments. Some mechanisms respond to specific cues, such as the OxyR-dependent response to hydrogen peroxide or the SOS-response that is induced upon DNA-damage. These specific responses c...

Gao Z, Dai Y, Shen R, Dong W, He H, Wang K et al.

Understanding the interaction mechanisms between ionic liquids (ILs) and proteins is crucial for advancing IL-based biocatalysis and pharmaceutical applications. This study employed molecular dynamics (MD) simulations to systematically demonstrate the structural and solvation behaviors of the &#x...

Saad A, Raya J, Bechinger B

In this study, we present an atomic-level structural investigation of the magainin 2 antimicrobial peptide reconstituted in extended lipid bilayers that closely mimic the composition of bacterial membranes. Using state-of-the-art solid-state NMR spectroscopy, we show that within liquid-crystallin...

Vasilescu AM, Vasilescu AG, Sima LE, Munteanu CVA, Baran N, Szedlacsek ȘE et al.

Acute Myeloid Leukemia (AML) is a group of very aggressive hematological malignancies, with dismal long-term survival rates and little therapeutic recourse presently. The transmembrane ligand B7-H3 is a known therapeutic target, biomarker of response and correlated with an unfavorable prognosis i...

Wang Y, Li M, Huang F, Qiu M, Zhang W

Generative models have shown considerable promise in antimicrobial peptide design; however, their ability to generate pathogen-specific peptides remains limited due to data scarcity. In this study, KPPepGen, a controllable generative framework that leverages knowledge-aware pathogen prompts deriv...

De K, Bryder K, Aisenbrey C, Mörgelin M, Bechinger B

Collagen VI is an extracellular matrix protein forming complex microfibrillar networks in connective tissues. Specifically, we focused on its role in innate immunity, in particular on cationic sequence motifs from the α3(VI)-chain, which exhibit strong antibacterial properties against both ...

Li C, Zhou QQ, Yu T, Zhang X, Kang Z, Zhou M et al.

Antimicrobial peptides (AMPs) can rapidly kill bacteria via disrupting the integrity of the cytoplasmic membrane. Although the understanding of the interaction between AMPs and phospholipid membrane is essential for related drug designs, the in situ observation of this process is still challengin...

Bae D, Kim M, Seo J, Nam H

The rise of antibiotic-resistant bacteria drives an urgent need for novel antimicrobial agents. Antimicrobial peptides (AMPs) show promise solutions due to their multiple mechanisms of action and reduced propensity for resistance development. This study introduces LLAMP (Large Language model for ...

Ayscough SE, Skoda MWA, Doutch J, Caruana A, Kinane C, Clifton L et al.

Membrane proteins serve a wide range of vital roles in the functioning of living organisms. They are responsible for many cellular functions, such as signalling, ion and molecule transport, binding and catalytic reactions. Compared to other classes of proteins, determining membrane protein struct...

Maron B, Zanchi C, Johnston P, Rolff J, Friedman J, Hayouka Z et al.

Antimicrobial resistance (AMR) poses a critical global health challenge, prompting the exploration of antimicrobial peptides (AMPs) as alternatives. Here, we investigated the genetic mechanisms of resistance evolution in Staphylococcus aureus against single and combined AMPs (temporin, melittin, ...

Deng Y, Chen S, Tuerxun M, Xiong X, Tang J

Infected bone defects represent one of the most prevalent clinical conditions, affecting millions of patients annually. The local infection and necrosis associated with these defects exacerbate the injury, prolong healing times, and result in significant localized pain, presenting a substantial c...

Hirschler E, Glattard E, Arnaud N, Chicher J, Hammann P, Leize-Wagner E et al.

In this study, we applied cross-linking mass spectrometry (XL-MS) to characterize the oligomeric states of a PGLa/magainin 2 mixture and gain insight into the heterodimerization previously suggested in the literature. Both peptides have shown a synergistic enhancement of activity when tested in a...

Hirano M, Takechi-Haraya Y, Abe Y, Misawa T, Shibata N, Sato Y et al.

In this study, the mechanism of the plasmid DNA (pDNA) delivery system using Magainin 2-derived stapled peptides (st7-5 and st7-5_R) was analysed. The effect of different cationic residues (Lys and Arg) on the stability and intracellular transport efficiency of the peptide/pDNA complex was assess...