Livagen Research

Maehara H, Hatano A, Shirai M, Kokaji T, Suzuki Y, Matsumoto M et al.

Obesity impairs hepatic functions through abnormal functional protein expression, potentially through DNA methylation, which suppresses gene expression, and changes in transcription factors (TFs) expression. However, the specific protein expression changes associated with DNA methylation in the o...

Kanamori Y, Nita A, Nakayama KI, Kurotaki D, Harada K, Moroishi T et al.

Although it is well documented that iron promotes hepatocyte death in chronic liver disease, recent studies have suggested that iron in hepatocytes also has a protective role against such disease. However, the mechanisms underlying this beneficial role of iron remain poorly understood.F-box and l...

Miura S, Horisawa K, Inada H, Sakaguchi Y, Yorino M, Suzuki A et al.

Direct reprogramming is a technique for elucidating the mechanisms that control cell-fate decisions and holds promise as a therapeutic strategy. We previously showed that a specific combination of three transcription factors (FOXA3, HNF1A, and HNF6) can induce direct reprogramming of human umbili...

Hanafusa R, Tajiri K, Muraishi N, Hirabayashi K, Tsuneyama K, Yasuda I et al.

Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease caused by an autoimmune response to hepatocytes, predominantly affecting middle-aged and older women. A subset of AIH cases has been associated with immunoglobulin G4-related disease (IgG4-RD), referred to as IgG4-AIH. This rare c...

Matsumoto T, Nita A, Kanamori Y, Maeda A, Nita T, Yasuda-Yoshihara N et al.

Ferroptosis, a distinctive form of cell death induced by iron-dependent lipid peroxidation, is implicated in various biological processes, including liver diseases. Establishing an iron overload-induced ferroptosis model and identifying hepatic gene signatures associated with ferroptosis are cruc...

Yuan K, Meng HM, Sun H, Qu L, Li Z, Tan W et al.

Invasion and metastasis dominate tumor progression, causing a substantial proportion of cancer-related deaths. However, the efficacy of current antimetastatic treatments is hampered by the dearth of targeted therapeutics. Recently developed synthetic-receptor toolkits offer potential for artifici...

Aki D, Hayakawa T, Srirat T, Shichino S, Ito M, Saitoh SI et al.

Metabolic dysfunction-associated steatotic hepatitis (MASH) is a chronic progressive liver disease that is highly prevalent worldwide. MASH is characterized by hepatic steatosis, inflammation, fibrosis, and liver damage, which eventually result in liver dysfunction due to cirrhosis or hepatocellu...

Augusto Silva Dos Santos Rodrigues P, Lima de Oliveira A, Mattos Brandão K, de Sá Garcia Landeiro L, Cardoso Calmon L, Victor Andrade Cruz J et al.

Rheumatoid arthritis (RA) is a multifactorial autoimmune inflammatory disease that mainly affects the joints, on reducing functional capacity and impacting quality of life. Cytokines such as tumor necrosis factor (TNF) and interleukin 6 (IL-6) are crucial in the pathogenesis and treatment of this...

Miura S, Horisawa K, Iwamori T, Tsujino S, Inoue K, Karasawa S et al.

Hepatocytes play important roles in the liver, but in culture, they immediately lose function and dedifferentiate into progenitor-like cells. Although this unique feature is well-known, the dynamics and mechanisms of hepatocyte dedifferentiation and the differentiation potential of dedifferentiat...

Maejima Y, Yokota S, Yamachi M, Misaka S, Ono T, Oizumi H et al.

The high prevalence of obesity has become a pressing global public health problem and there exists a strong association between increased BMI and mortality at a BMI of 25 kg/m2 or higher. The prevalence of obesity is higher among middle-aged adults than among younger groups and the combination of...

Torigoe S, Lowman DW, Sugiki T, Williams DL, Yamasaki S

Dectin-1 is a well-characterized C-type lectin receptor involved in anti-fungal immunity through the recognition of polysaccharides; however, molecular mechanisms and outcomes initiated through self-recognition have not been fully understood. Here, we purified a water-soluble fraction from mouse ...

Ghosh A, Banik S, Yamada K, Misaka S, Prud'homme RK, Sato H et al.

In this study, we developed stabilized astaxanthin (AX) nanoparticles (sNP/AX) to improve the physicochemical properties, oral bioavailability, and hepatoprotection of AX. A flash nanoprecipitation technique was used with a multi-inlet vortex mixer to prepare the sNP/AX. Vitamins E (VE) and C (VC...

Matsukawa T, Yagi T, Uchida T, Sakai M, Mitsushima M, Naganuma T et al.

Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes are interacting comorbidities of obesity, and increased hepatic de novo lipogenesis (DNL), driven by hyperinsulinemia and carbohydrate overload, contributes to their pathogenesis. Fatty acid synthase (FASN), a key enzyme of hepatic DNL,...

Kaburagi T, Otsuka Y, Oshiro S

The sialic acid N-acetylneuraminic acid (NANA), an essential factor in bioregulation, is a functional food component that is known to have beneficial health effects, but its antiobesity effect has not been clearly understood. Adipocyte dysfunction in obesity involves a decrease in the level of NA...

Fujinuma S, Nakatsumi H, Shimizu H, Sugiyama S, Harada A, Goya T et al.

Nonalcoholic fatty liver disease (NAFLD) is a chronic metabolic disorder caused by overnutrition and can lead to nonalcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC). The transcription factor Forkhead box K1 (FOXK1) is implicated in regulation of lipid metabolism downstream of m...

Lezhava T, Jokhadze T, Monaselidze J, Buadze T, Gaiozishvili M, Sigua T et al.

In the present study, on the one hand, the epigenetic modification of condensed "old" chromatin was determined, and on the other hand, the influence of peptide bioregulators (Ala-Glu-Asp-Gly-Epitalon; Lys-Glu-Asp-Ala-Livagen; Ala-Glu-Asp-Pro - Cortagen and Lys-Glu - Vilon) on condensed chromatin ...

Ito Y, Uda S, Kokaji T, Hirayama A, Soga T, Suzuki Y et al.

Interactions between various molecular species in biological phenomena give rise to numerous networks. The investigation of these networks, including their statistical and biochemical interactions, supports a deeper understanding of biological phenomena. The clustering of nodes associated with mo...

Yagai T, Nakamura T

Non-alcoholic fatty liver disease (NAFLD) is one of the most prevalent hepatic disorders that 20-30% of the world population suffers from. The feature of NAFLD is excess lipid accumulation in the liver, exacerbating multiple metabolic syndromes such as hyperlipidemia, hypercholesterolemia, hypert...

Ni Y, Zhuge F, Ni L, Nagata N, Yamashita T, Mukaida N et al.

Chemokine (C-X3-C motif) ligand 1 (CX3CL1) and its receptor CX3CR1 regulate the migration and activation of immune cells and are involved in the pathogenesis of nonalcoholic steatohepatitis (NASH), but the mechanism remains elusive. Here, the roles of CX3CL1/CX3CR1 in the macrophage migration and...

Zhao W, Mori H, Tomiga Y, Tanaka K, Perveen R, Mine K et al.

There is an association between nonalcoholic fatty liver disease (NAFLD) and atherosclerosis, but the genetic risk of atherosclerosis in NAFLD remains unclear. Here, a single-nucleotide polymorphism (SNP) of the heat shock 70 kDa protein 8 (HSPA8) gene was analyzed in 123 NAFLD patients who had b...