Liraglutide Research

Razmi S, Moshtaghie AA, Seyedabadi M, Hashem N, Akbarzadeh S

Exercise-induced ionic changes can modulate the interaction between liraglutide and the glucagon-like peptide-1 receptor (GLP-1R). To investigate this, molecular dynamics simulations and in vivo experiments using streptozotocin-induced diabetic rats were performed. Under exercise-mimicking ionic ...

Smith BL, May A, Lalani F, Hasham S, Presnell AA

Obesity is a chronic, multifactorial disease associated with significant metabolic, physical, and psychosocial complications. Although advances in pharmacologic therapy-particularly glucagon-like peptide-1 (GLP-1)-based agents-have expanded treatment options, challenges persist in the effective m...

Kamath S, Chan NSL, Joyce P

Glucagon-like peptide-1 (GLP-1) receptor agonists have transformed the management of type 2 diabetes mellitus (T2DM) and obesity, yet their interactions with the gut microbiome remain an emerging frontier in pharmacological and metabolic research. Mounting evidence suggests that the gut microbiot...

Belančić A, Antza C, Poutachidis A, Palaska S, Gkrinia EMM, Faour AK et al.

Metabolic liver disease, including nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis, is a major cause of chronic liver dysfunction worldwide, creating an urgent need for effective treatments. This systematic literature review (SLR) and network meta-analysis (NMA) systemat...

Kahles F, Birkenfeld AL, Marx N

The incretin hormone glucagon-like peptide-1 (GLP-1) exerts potent effects on glucose metabolism, prompting the development of therapeutic strategies that enhance activity of the GLP-1 receptor (GLP-1R) pathway. Inhibitors of dipeptidyl peptidase 4 (DPP-4) prolong the half-life of endogenous GLP-...

Patil S, Jha N, Jha MK

Substance use disorders (SUDs) are widely prevalent and associated with high morbidity and mortality. Current treatments have limited efficacy and there are no United States Food and Drug Administration (FDA)-approved treatments for several SUDs (such as methamphetamine, cocaine, and cannabis use...

Łuczak PM, Perediatkiewicz J, Liszka P, Puchalski K, Patrzykąt KM, Olejnik-Chlewicka KM et al.

Pediatric obesity is a common chronic disease with serious long-term health consequences. This narrative review compares current international and national recommendations for the diagnosis and management of pediatric obesity. We focus on guidance from the American Academy of Pediatrics (AAP), th...

Sánchez-García D, Luna-Garza Y, Saavedra-Castillo E, Gómez-Martínez G, Diaz-Sallas M, Ortega-Valdez AC et al.

To evaluate the effect of liraglutide on carotid intima-media thickness (CIMT) and cardiometabolic risk in adults with type 1 diabetes (T1D).We conduct a prospective, quasi-experimental study including adults aged 15-60 years with T1D, suboptimal control and on basal-bolus insulin regimen....

Bai S, Wei M, Wu Y, Zhu X, Wang Z, Wang Y et al.

Postoperative delirium (POD) is a common and serious complication after cardiac surgery, particularly in elderly patients, and is associated with adverse short- and long-term outcomes. Effective preventive strategies remain limited. Liraglutide, a glucagon-like peptide-1 receptor agonist, has dem...

Menkü Özdemir FD, Uzun H

Skin redundancy after massive weight loss often requires body contouring procedures such as abdominoplasty and mastopexy. Bariatric patients may face higher complication risks due to nutritional deficiencies. However, with proper management, including stable body weight and adequate nutritional s...

Mai T

Durable glycemic control remains challenging in patients with type 2 diabetes mellitus inadequately controlled with metformin alone. Liraglutide, a glucagon-like peptide-1 receptor agonist, has been proposed as a beneficial add-on therapeutic option. This retrospective study included adults with ...

Yang H, Yu W, Gao Y, Wang J, Xu S

The glucagon-like peptide-1 receptor (GLP-1R) agonist liraglutide is an effective therapeutic agent for obesity, primarily through its ability to suppress appetite and delay gastric emptying. However, the central neural substrates mediating its effects on food intake remain incompletely defined.M...

Sioufi MC, Heroiu I, Wong S, Le GH, Dri CE, Zheng YJ et al.

Impaired autophagy has been implicated in the pathophysiology of neurodegenerative disorders, such as Alzheimer's Disease (AD) and Parkinson's Disease (PD). Consistent and replicated evidence indicate that Glucagon-like Peptide-1 Receptor Agonists (GLP-1RAs) exert treatment and preventative effec...

Gong B, Shi Z, Qi J, Wang F, Chen G, Su H et al.

Sepsis-induced organ dysfunction poses a significant clinical challenge with limited therapeutic options. This study investigated the therapeutic potential of the glucagon-like peptide-1 receptor agonist (GLP-1RA) liraglutide in sepsis and its underlying mechanisms, focusing on modulation of the ...

Mottalib MM, Beheshti R, Viswanathan K, Bunnell HT, Phan TT

There are limited paediatric studies comparing outcomes from different obesity medications (OMs) in real-world settings. The aim of this study is to describe real-world variability in outcomes and develop models to predict outcomes from OMs.We examined electronic health record (EHR) data of patie...

Shen Y, Zhang M, Yang T, Wu Y, Qiu Y, Zhang L et al.

Periodontal ligament stem cells (PDLSCs) hold great promise for periodontal regeneration therapy. However, their self-renewal and multilineage differentiation capabilities are often compromised by adverse factors in the periodontal microenvironment. Therefore, identifying novel therapeutic target...

Abo El-Magd NF, Ramadan NM, Eraky SM

Aluminum toxicity in rodents is well documented to be used for inducing experimental models that mimic the clinical phenotypes of Alzheimer's disease (AD). Liraglutide is a well-known antidiabetic drug promising for modulating neurodegenerative conditions. Thus, investigating the ameliorative eff...

Lee Y, Shin M, Chung S, Jung J, Sul AR, Hong YH et al.

Childhood obesity is a critical public health issue that often persists into adulthood, posing significant treatment challenges. Establishing long-term healthy habits is essential, and South Korea has implemented various policies to manage pediatric obesity. However, a gap remains between policy,...

Nordell P, Jansson-Löfmark R, Gennemark P

Peptide-based therapeutics represent a rapidly expanding class of drugs. Endogenous peptides typically exhibit short elimination half-lives due to proteolytic cleavage and renal filtration. However, modifications such as amino acid substitutions and fatty-acid conjugation can significantly prolon...

Shevchouk O, Edvardsson CE, Ericson M, Blid Sköldheden S, Zhang Q, Dreher Nabinger D et al.

Beyond the metabolic effects induced by long- and short-acting glucagon-like peptide-1 receptor (GLP-1R) agonists, they modulate reward-related behaviors by acting on brain regions including lateral septum (LS) and neural pathways involving the nucleus tractus solitarii (NTS). While the short-act...