Linaclotide Research

Chen H, Wang J, Fan C, Zhuang K, Yuan L, Li H et al.

The benefit of combining linaclotide with polyethylene glycol (PEG) for improving bowel preparation quality and adenoma detection in patients at risk for inadequate bowel preparation remains uncertain. This study aimed to evaluate its efficacy and safety.From August 2022 to July 2023, a multicent...

Abideen ZU, Waseem MH, Shoaib A, Ramzan NU, Ch MTA, Thada PK et al.

Colonoscopy effectiveness in detecting colorectal carcinoma depends on adequate bowel preparation (ABP). This network meta-analysis assesses the efficacy and safety of various bowel preparation regimens in patients with constipation.PubMed, Cochrane Central and ScienceDirect were searched till Ap...

Liu L, Zeng J, Wang J, Zheng Y, Liu H, Liu Z et al.

Linaclotide, a promising medication for treating irritable bowel syndrome with predominant constipation, has the potential to enhance bowel preparation for colonoscopy. This study aims to evaluate the efficacy and tolerability of linaclotide combined with low-volume polyethylene glycol (PEG) in c...

Cheng J, Zhang T, Cui X, Wu P, Li M, Hu W et al.

Linaclotide is an important peptide drug used to treat irritable bowel syndrome with constipation (IBS-C). However, structurally related impurities in peptide drugs can be generated during synthesis, storage, or transport, which compromise the quality and safety. Therefore, developing a highly se...

Mou JJ, Xu L, Luo YF, Tao QF, Wang ZZ, Chen M et al.

Intestinal secretagogues and prokinetic agents are commonly used for managing irritable bowel syndrome with constipation (IBS-C). However, no studies have provided direct head-to-head comparisons of these medications. This study aimed to evaluate the dose-stratified relationships and safety profi...

Sahu SK, Nath P, Mallick B, Praharaj D, Giri S, Panigrahi SC et al.

Chronic idiopathic constipation (CIC) and constipation-predominant irritable bowel syndrome (IBS-C) are two highly prevalent functional gastrointestinal disorders that share overlapping features but differ in their pathophysiology and symptom profiles. Both conditions impose a significant socioec...

Lambiase C, Pagliaro G, Cocca S, Deloose E, Demedts I, Morganti R et al.

Polyethilenglicole (PEG), bisacodyl, prucalopride, and linaclotide were demonstrated to be superior to placebo for the treatment of chronic constipation. In a recent study, we reported the actions of PEG, bisacodyl, and prucalopride on colonic motor patterns. The aim of the present study was to e...

Eid AM, Vázquez-Vélez GE, Maliszewski B, Butler M, Bucelli RC, Perlmutter JS et al.

Autonomic disorders disrupt homeostasis and cause symptoms such as orthostatic hypotension, urinary urgency, bladder overfilling, sexual dysfunction, constipation, and gastroparesis. Pathophysiologic mechanisms include neurodegeneration, autoimmunity, toxic exposure, medication-induced, and an ar...

Xiu R, Reiner J, Hofmann F, Salari A, Seidler U

Guanylate cyclase-C (GC-C) is the receptor for endogenous (uro)guanylin peptides, bacterial toxins and pharmacological analogues. Receptor activation leads to intestinal fluid loss, but also activates an antiproliferative pathway and is a promising target in colorectal cancer therapy. The present...

Yang S, Jiao X, Lou X, Du Y, Zhao K, Shan L et al.

Sonodynamic therapy (SDT) has gained attention as a promising non-invasive cancer treatment strategy due to its localized effects and superior tissue penetration. SDT induces apoptosis and immunogenic cell death (ICD) via the generation of reactive oxygen species (ROS) upon ultrasound irradiation...

Williamson D, Vishnevetsky J, Ando M, Xu Y, Ye X, Abel JL et al.

Patient-reported outcomes (PROs) are required to assess the efficacy of treatments for functional constipation (FC), which is one of the most common functional gastrointestinal disorders in children. A novel PRO, the Pediatric Functional Constipation Symptom Diary (PFCSD), was developed to assess...

Ren YP, Chan WL, Chuah KH, Kim YS, Nakajima A, Mahadeva S et al.

: Chronic constipation is prevalent yet under-diagnosed across Asia, compromising quality of life and burdening healthcare systems. Cultural stigma, varied diets, and limited access to standardized diagnostic tools delay timely care.: The Bali Chronic Constipation Roundtable in November 2024, bro...

Ali O, Monrroy M, Lightle A, Faddoul G

Oxalate nephropathy (ON) is a rare condition caused by calcium oxalate crystal deposition in renal tubules, leading to acute kidney injury (AKI), chronic kidney disease (CKD), or both. The etiologies of ON are divided into two main categories: primary and secondary. Linaclotide is used for the co...

Sun W, Zhao L, Ran Y, Zhao W, Zhang L, Xiao J et al.

This study aimed to investigate the efficacy and safety of bowel preparation by linaclotide (Lina) combined with compound polyethylene glycol (PEG) in patients aged over 60 years.A multi-center, endoscopist-blind, randomized controlled trial involved 527 patients aged over 60 years ...

Farag A, Genidy AM, Raslan M, Gadelrab MN

High-volume polyethylene glycol (PEG) is widely used for bowel preparation, but its large volume and unpleasant taste are common drawbacks. These factors frequently lead to reduced patient adherence. Linaclotide, an FDA-approved drug for constipation, appears to offer a potential solution by lowe...

Meine GC, Brennan GT, Delgado LM, Santo P, Osikoya O

Polyethylene glycol (PEG) is the standard agent for bowel preparation in colonoscopy. However, its combination with linaclotide may enhance bowel cleansing.This systematic review and meta-analysis compared the efficacy and safety of linaclotide combined with PEG versus PEG alone in patients under...

Hojo M, Igarashi A, Shoji A, Nagahara A

Chronic constipation reduces quality of life and imposes a significant economic burden. The introduction of novel agents in Japan has expanded treatment options. This study aimed to establish a cost-effective treatment strategy, considering clinical utility and patient satisfaction.Nine treatment...

Wu Y, Grieme A, Liu KS, Nguyen V, Adamson C, Garza M et al.

Adjunct agents in bowel preparation for colonoscopy have the potential to improve procedure outcomes. We performed a systematic review and meta-analysis to investigate the effects of adjunct single-dose linaclotide with bowel prep on colonoscopy outcomes.We conducted a comprehensive search in Pub...