Leuprolide Research

Patel SA, Yadalam AK, van Assen M, Cantu SM, Onnis C, Zheng B et al.

Androgen deprivation therapy (ADT) for men with prostate cancer (PCa) is associated with cardiovascular (CV) morbidity, yet the biological basis remains unclear. Recent studies have yielded conflicting results regarding the CV safety of gonadotropin-releasing hormone (GnRH) agonists vs antagonist...

Rai SK, Kumar R, Khan MI, Kumar A

Endometriosis is a complex, estrogen-dependent disease with limited effective treatments that often focus on symptom management rather than addressing the underlying pathology. Current therapies, such as progestins and GnRH agonists, have significant side effects (weight gain, mood changes, decre...

Taggar A, Ulrich A, Tan Y, Luciano DE, Sanders M, Courtois ET et al.

To study the associations of B cell lymphoma 6 (BCL6) in endometrial endometriosis, and to determine a practice's experience testing BCL6 in patients with recurrent pregnancy loss/recurrent implantation failure (RPL/RIF).Retrospective chart review.Endometrial samples were collected at the time of...

Tran B, Yeh N, Gayle A, Holmes E, Hu J, Damineni S et al.

An understanding of how androgen deprivation therapy (ADT) prescribing patterns impact patient outcomes in a real-world setting is needed to help inform treatment decisions and improve the care of patients with prostate cancer (PCa). REASSURE was a retrospective, observational study that describe...

Klein KO, Mauras N, Nayak S, Sunil B, Soliman AM, Kansra AR et al.

The long-term safety and efficacy of leuprolide acetate (LA) intramuscular (IM) depot in children with central precocious puberty (CPP) have not been examined.We evaluated the 144-week efficacy and safety of LA IM depot with 6-month dosing frequency for the treatment of CPP.Children with CPP rece...

Albak Y, Sönmez Ünal G, Yıldız Ç, Çetin M, Durna Daştan S, Gümüş E et al.

Endometriosis is a benign condition driven by estrogen and inflammation in which endometrial-like tissue develops in ectopic locations. We aimed to determine whether non-steroidal agents acting on the WNT/beta-catenin signaling axis could provide therapeutic benefit in this disease.Forty adult fe...

Feltes Benítez N, Galdeano-Rubio M, Muñoz-Rodriguez J, Domínguez A, Solé I Monné JM, Pérez Márquez M et al.

ADT is routinely combined with radiotherapy (RT) for intermediate- and high-risk prostate cancer. While prostate shrinkage may facilitate planning, prospective CT-based, patient-level estimates over short, workflow-relevant intervals are scarce.We conducted a prospective study of 47 patients star...

Kobori H, Kumakiri J, Murakami K, Kawasaki Y, Takeuchi S, Fukui M et al.

To evaluate the preoperative oral relugolix treatment of patients undergoing laparoscopic myomectomy and to test the noninferiority of preoperative treatment with relugolix versus leuprorelin on intraoperative blood loss.Multicenter, randomized, open-label, active-controlled, parallel group trial...

Sridhar S, Muthu AK, Palaniappan S, Nandini K, Chandrasekaran A, Kalavathy R et al.

17β-Hydroxysteroid dehydrogenase 3 (17β-HSD3) deficiency is a rare 46XY disorder of sex development (DSD) of androgen biosynthesis. We aimed to describe the complexities in diagnosis, gender assignment, and the timing of irreversible surgical interventions in 17β-HSD3 deficiency...

Sandhu K, Wells C, Newton MMH, Murphy DG, Lawrentschuk N, Perera ML et al.

Androgen deprivation therapy (ADT) has been pivotal in advanced prostate cancer (PCa) for decades. The introduction of androgen-receptor pathway inhibitors (ARPIs) has transformed treatment paradigms. However, their real-world adoption over time has not been comprehensively characterised. We exam...

Roberts L, Stokvis K, Christianson M, Gojo I, Seraphin M, Newman M et al.

Bleeding complications significantly contribute to morbidity and mortality of patients with hematologic malignancies. Although there is some evidence for treatment and prevention of uterine bleeding in patients with cancer, there is no specific guidance used universally for hematologic malignanci...

Rozet F, Ruffion A, Lemercier P, Soulié M, Robert G, Walz J et al.

Androgen-deprivation therapy survival benefits after radical prostatectomy (RP) in nonmetastatic high-risk prostate cancer (PCa) patients with an undetectable prostate-specific antigen (PSA) level are unclear. The AFU-GETUG-20 study assessed the benefit of leuprorelin immediately after RP in this...

Pierpoint SC, Gonzalez AM, Peavey MC, Williams CD, Smith LP, Purcell SH et al.

To evaluate the effectiveness of the progestin-suppressed in vitro fertilization (IVF) stimulation protocol in patients with diminished ovarian reserve.Retrospective cohort study.Women aged 18-45 years in an academic-affiliated private fertility practice with antimüllerian hormone values &lt...

Wang P, Wang K, Yin S, Liu X, Xie W, Li H et al.

Cyclic peptides hold great promise in drug discovery due to their conformational stability, proteolytic resistance, and ability to disrupt protein-protein interactions (PPIs). However, their therapeutic potential is often constrained by reversible binding, while covalent labeling strategies such ...

Summey RM, Iden M, Tsaih SW, Schmidt R, Parashar D, Wang S et al.

This study investigated the mechanism of action and in vitro efficacy of an anti-hormonal combination drug regimen in treating adult-type granulosa cell tumors of the ovary (AGCT). Using patient-derived and commercial AGCT cell lines, the IC50 values of bicalutamide, anastrozole, and leuprol...

Sheth A, Dietz N, Becerril-Gaitan A, Kasem R, Mistry A, Williams BJ et al.

Hemangioblastomas are rare, benign vascular tumors of the central nervous system that are often found in the cerebellum, brainstem, or spinal cord. Common clinical symptoms are related to the mass effect, such as headaches, ataxia, and hydrocephalus. While hemangioblastomas frequently present wit...

Patel VM, Cai Q, Ahn R, Hill K, Wang J

Treatment options for refractory prostate-specific membrane antigen (PSMA)-negative liver metastases from metastatic castration-resistant prostate cancer (mCRPC) are limited and challenging. This case report presents our clinical observation of a sustained response to a novel combination of metro...

Wu X, Chen W, Yong Q, Zeng Q, You J, Zeng K et al.

Leuprorelin-induced perimenopausal syndrome (LIPS) represents a common challenge faced by infertile women undergoing assisted reproductive procedures, characterized primarily by hot flashes, night sweats, and mood swings. Currently, there is a shortage of safe approaches that can effectively alle...

Isaacson EE, Richardson R, McCracken K, Rosen MW, Dendrinos M

Patients with obstructive Müllerian anomalies (OMAs) experience significant pain secondary to hematometrocolpos and often require menstrual suppression to achieve symptomatic pain control and to optimize timing before surgical intervention. Currently, there are limited data on menstrual supp...