Lanreotide Research

Slott C, Langer SW, Oturai P, Møller S, Hansen CP, Kjaer A et al.

Small intestinal neuroendocrine tumors (siNET) are rare malignancies, often diagnosed at advanced stages with metastatic spread. While surgery is the only curative treatment, medical therapies, including somatostatin analogues (SSA), peptide receptor radionuclide therapy (PRRT), and other systemi...

Saigusa S, Sakurai H, Fujikawa H, Watanabe S, Fukumochi K, Uchiyama Y et al.

Lanreotide is a synthetic polypeptide analog of somatostatin that is used to treat gastroenteropancreatic neuroendocrine tumors (NETs). Although granulomatous inflammation is caused by a variety of conditions, lanreotide acetate subcutaneous injection-induced granulomatous inflammation has not be...

Elballa WM, Gregory A, Siahaan TJ, Hageman MJ

In vitro models used to investigate drug diffusion face certain limitations and challenges because they omit for mucus interactions that could influence diffusional transport. This study developed a simple mono-component mucin model using Mucin Type II from porcine stomach to predict the effects ...

Sato T, Nishio A, Kegasawa T, Hazu K, Tarumi C, Yamada K et al.

A 68-year-old man with postprandial flushing and palpitations was referred for multiple hepatic lesions. Computed tomography showed hypoattenuating metastases without a detectable primary, whereas contrast-enhanced ultrasound revealed arterial hyperenhancement and Kupffer-phase defects, indicatin...

Liang Y, Xu J, Huang D, Tang W, Sun Z, Chen L et al.

Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine neoplasms characterized by heterogeneous clinical and genetic profiles. Evidence regarding the efficacy of systemic therapies in this population remains limited. We retrospectively reviewed 157 PPGL patients treated at our cente...

Ribeiro Junior MAF, Fontenelle Vieira L, Thalib HI, Fouzaan Albeez S, Heba Fakruddin F, Mirza Zafar Baig A et al.

External gastrointestinal fistulas (EGIFs) are serious postoperative complications associated with prolonged hospital stays, sepsis, malnutrition, and high mortality rates. Reducing gastrointestinal secretions with somatostatin or its analogues may facilitate fistula closure. The clinical effecti...

Wang S, Ko HM, Lukin DJ, Scherl E, Kiran R, Shen B et al.

Ileal pouch cancer in patients with inflammatory bowel disease, though rare, represents a significant concern due to the high mortality. While prior studies emphasized incidence and risk factors, this study evaluates the current management and prognosis of pouch cancer following ileal pouch-anal ...

Perrone E, Shaheen S, Kunz PL, Henri HC, Baum RP

A 78-year-old man with neuroendocrine neoplasm (NEN) G2 originating from a presacral tailgut cyst was previously treated with surgery, lanreotide and [177Lu]Lu-DOTATATE peptide receptor radionuclide therapy (PRRT). Due to recurrence, confirmed by [68Ga]Ga-DOTA-LM3 PET/CT, which showed local, hepa...

AlQahtani MS, Miutescu B, Domilescu I, Negru S, Popovici D, Gadour E et al.

Background: Pancreatic neuroendocrine tumor (pNET) is a rare and complex disease that requires careful management and treatment. Currently, a range of treatments, including surgery, somatostatin analogs (SSA), peptide receptor radionuclide therapy (PRRT), targeted drugs, cytotoxic chemotherapy, a...

Elhadd T, Dabbous Z, Abdelmahmuod EA, Rohani Z, Kailani YA

Acromegaly, a rare endocrine disorder characterised by excess growth hormone (GH) and insulin-like growth factor 1 (IGF-1), is often due to GH-secreting pituitary adenomas. Pasireotide, a second-generation somatostatin receptor ligand (SRL), binds to multiple somatostatin receptors (SSTRs) and of...

Zhang T, Chen T, Tang X

Ménétrier's disease (MD) is a rare, acquired premalignant condition characterized by hypertrophic gastropathy. Its defining features include giant gastric rugal folds, predominantly in the fundus and body of the stomach, foveolar hyperplasia with glandular atrophy, and a protein-losing ...

Fakir S, Sarker MMR, Sigdel M, Barabutis N

Growth hormone (GH) is a peptide hormone produced by the anterior pituitary gland, which regulates growth and development. Abnormal levels of GH have been associated with a diverse variety of disorders affecting life quality and longevity; including dwarfism, acromegaly, gigantism and cancer. Bas...

Martinez-Gil M, Aghel S, Tshimbombu TN, Yuen KCJ

Dopamine agonists have been used in the treatment of acromegaly, but they are modestly effective and are rarely associated with impulse control disorders (ICDs). We present the case of a 34-year-old woman with acromegaly who underwent transsphenoidal resection for an invasive pituitary macroadeno...

Vitale L, Fatti LM, Bonomi M, Frara S, Vitale G, Persani L et al.

We report the case of a 71-year-old woman with acromegalic facies, referred following bilateral idiopathic lens luxation (LL). Subsequent investigations revealed a 15-mm pituitary adenoma, along with biochemical evidence of massive growth hormone hypersecretion (Growth Hormone (GH): 93.22 µg...

Chiloiro S, Palumbo C, Giampietro A, De Marinis L, Bianchi A, Giustina A et al.

Acromegaly is a rare disease caused by the elevated and autonomous secretion of growth hormone (GH) from a pituitary somatotroph tumor or neuroendocrine tumors, and the subsequent hypersecretion of insulin-like growth factor I (IGF-I) in peripheral tissues. Excess GH and IGF-I cause several ...

Gandy G, Prudence AJA, Levy MT

Chronic secretory diarrhoea is a diagnostic challenge with a broad differential and significant impact on patient's quality of life. While common causes include microscopic colitis, bile acid diarrhoea, and laxative use, rarer aetiologies such as vasoactive intestinal peptide (VIP)-secreting neur...

Brunzell E, Högström YK, Hernández ML, Pedersen JS, Bergström LM

Amphiphilic compounds, such as phospholipids or surface-active substances, are present in biological systems and can be part of pharmaceutical formulations. As a consequence, all pharmaceutically active ingredients will encounter amphiphilic compounds, either in the formulation or after administr...

Faria R, Balanco L, Almeida V, Ferreira PG

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare interstitial lung disease characterized by diffuse proliferation of neuroendocrine cells in the airway mucosa and regarded as a preneoplastic condition. It typically affects nonsmoking middle-aged or elderly women an...

Sun Y, Lu D, Gao J

Acromegaly is an endocrine disorder characterized by abnormal enlargement of the extremities and internal organs resulting from excessive secretion of growth hormone (GH) by the pituitary gland, which in turn leads to elevated levels of insulin-like growth factor 1 (IGF-1). Approximately 45% of p...

Stanciu M, Cătană A, Ristea RP, Tanasescu D, Carsote M, Popa FL et al.

Acromegaly is associated with a higher risk of certain malignancies, but not hematological neoplasia, although multiple myeloma (MM) was found in very limited cases. We aim to present such a case, adding a particular presentation with co-occurrence of a plasmocytoma. A 52-year-old male with acrom...