Lactoferricin Research

Stepanyan L, Israyelyan M, Gori A, Tsaturyan A, Saribekyan Z, Hovsepyan K et al.

Antimicrobial peptides (AMPs), evolutionarily conserved components of innate immunity characterized by their broad-spectrum efficacy and minimal resistance development, are increasingly recognized as promising therapeutic candidates. This review aims to integrate current knowledge concerning natu...

Wang K, Gao Y, Jiang Z, Tong J, Zhang H

Bioactive peptides such as bovine lactoferricin (BLfcin) are gaining attention as functional agents to enhance animal health and reduce antibiotic reliance in dairy production. This study developed a chitosan nanoparticle (NP) delivery system to enhance the stability and efficacy of BLfcin, an an...

Vavilthota N, Babuççu G, Cordfunke RA, de Boer L, Balraadjsing P, Boekema BKHL et al.

Infected chronic wounds present a dual therapeutic challenge, requiring both the eradication of pathogens and the restoration of tissue homeostasis. Often the current treatments are ineffective against multidrug-resistant (MDR) pathogens and fail to promote wound healing. Antimicrobial peptides, ...

Mohanty J, Murali A

Plant viruses pose a serious threat to global agriculture and although chemical, genetic, and biological control strategies exist, but each method have limitations in effectiveness and sustainability. Recently, the use of microbial peptides for curbing the movement of plant viruses has gained mom...

Ardila-Chantré N, Barragán-Cárdenas AC, Reyes-Calderón JE, Franco-Zambrano DS, Matta-Orjuela EA, Rivera-Monroy JE et al.

This study focuses on the chimeric peptide KKWQWK-Ahx-RLLRRLLR and its interaction with cancer cells, specifically HPV18-positive cervical cancer HeLa and Ca Ski cells. The main objective of this study was to understand the mode of action of this chimera related to its cytotoxic activity, as well...

Sun M, Zhao Y, Ledesma-Amaro R, Gao J, Liu X, Bai Z et al.

Liquid-liquid phase separation (LLPS)-driven membraneless organelles (MLOs) have been employed to enhance metabolic efficiency in various microbial cell factories. However, their application in the industrial bacterium Corynebacterium glutamicum has not been explored. Here, we report the formatio...

Castellar-Almonacid D, Cuero-Amu KJ, Mendoza-Mendoza JD, Ardila-Chantré N, Chavez-Salazar FJ, Barragán-Cárdenas AC et al.

Palindromic antimicrobial peptides (PAMs) constitute versatile scaffolds for the design and optimization of anticancer agents with applications in therapy, diagnosis, and/or monitoring. In the present study, fluorolabeled peptides derived from the palindromic sequence RWQWRWQWR containing fluores...

Danskog K, Mistry N, Årdahl C, Durbeej M, Forsell MNE, Lenman A et al.

Although adenoviruses (AdVs) possess advantageous features as vectors, several challenges remain. These include a high prevalence of neutralizing antibodies against certain AdV types and the inability to efficiently transduce CAR-deficient cells and tissues. We showed previously that lactoferrici...

Castellar-Almonacid DA, Barragán-Cárdenas AC, Rodríguez-Mejia KG, Maldonado-Sanabria LA, Ardila-Chantré N, Mendoza-Mendoza JD et al.

Previous studies have shown that the palindromic peptide RWQWRWQWR derived from bovine lactoferricin (LfcinB) has exhibited selective in vitro cytotoxic effects against multiple cancer cells such as cervical, breast, and prostate cancer. We designed and synthesized peptides based on this palindro...

Pei J, Xiong L, Wu X, Chu M, Bao P, Ge Q et al.

The emergence and development of pathogenic bacterial resistance to antibiotics pose significant challenges to human health. Antimicrobial peptides (AMPs) are considered promising alternatives to conventional antibiotics. Lactoferricin (Lfcin), a cationic AMP located in the N-terminal region of l...

Sangboonruang S, Semakul N, Poomanee W, Thavanapong T, Roytrakul S, Charoenlappanit S et al.

Tuberculosis (TB) treatment faces significant challenges due to prolonged therapy and drug resistance, necessitating innovative anti-TB strategies. Thus, developing an innovative platform with effective anti-TB activity would offer more advantages. In this study, the pH-sensitive niosomal formula...

Huang T, Yang H, Zhao Y, Cui H, Qi X, Miao L et al.

Bovine lactoferrin-derived peptide LF-MQL was administered to healthy rats to assess its effects on growth parameters and gut morphology. Faecal samples were analysed by 16S rRNA high-throughput sequencing to investigate the modulatory effects of LF-MQL on the composition and diversity of the gut...

Varela-Quitián YF, Mendez-Rivera FE, Bernal-Estévez DA

Cancer is a major global health concern and one of the leading causes of death worldwide. According to the World Health Organization (WHO), there is an urgent need for novel therapeutic agents to treat this disease. Some antimicrobial peptides (AMPs) have demonstrated activity against both microb...

Zhao W, Zhang S, Sui L, Wang X, Li J, Cui W et al.

Foot-and-mouth disease virus (FMDV) and Senecavirus A (SVA) have similar pathogenic characteristics, and both are important pathogens that harm the livestock industry. Studies have shown that lactoferrin peptides can inhibit the replication of various viruses and enhance the body's immune functio...

Hazer Rosberg DB, Mahlapuu M, Perez R, Dahlin LB

Although advanced surgical techniques are available, satisfactory functional outcomes after peripheral nerve injuries are uncommon. Hence, immune-modulating factors such as PXL01, a lactoferrin-derived peptide that improves axonal outgrowth in injured human digital nerves, have gained attention. ...

Jang YS, Dehkohneh SB, Lim J, Kim J, Ahn D, Choi SS et al.

Lactoferrin-derived peptide chimera is a synthetic peptide that mimics the functional unit of lactoferrin with antibacterial activity. Although LF has anticancer effects, to the best of our knowledge, its effects on multiple myeloma have not yet been studied. We explored the potential of a lactof...

Tong J, Liu Z, Zhou K, Wang K, Guo S, Zhang H et al.

The overuse of antibiotics in livestock production poses a significant threat to public health, primarily by accelerating the emergence of antibiotic-resistant bacteria-a critical global issue. Therefore, the development of effective alternatives to antibiotics is urgently required to address thi...

Li Z, Wang X, Zheng D, Han F, Li Y, Zhou H et al.

Avian pathogenic Escherichia coli (APEC) infections result in significant economic losses and reduced animal welfare. Historically, antibiotics and vaccinations currently control APEC infections in poultry, however, antibiotic-resistant strains and heterologous serotypes limit their effectiveness...

Cui H, Yang H, Qi X, Zhao Y, Huang T, Miao L et al.

Bovine lactoferrin is a natural iron-binding glycoprotein known for its antimicrobial, antiviral, antitumor, anti-inflammatory, and immunomodulatory properties. In this study, we artificially recombined a fragment of bovine lactoferrin with immunomodulatory and antimicrobial properties to create ...

Sangboonruang S, Semakul N, Manokruang K, Khammata N, Jantakee K, Mai-Ngam K et al.

Chronic wound infections are attributed to delayed tissue repair, which remains a major clinical challenge in long-term health care. Particularly, infections with antibiotic resistance have more serious effects on health, often resulting in unsuccessful treatments. Thus, antimicrobial peptide (AM...