Oral delivery of peptide therapeutics remains challenging due to gastrointestinal (GI) degradation and poor intestinal absorption. Here, we propose a self-immolative peptide prodrug conjugate (SIPPC) platform for inflammation-targeted oral delivery, integrating a hydrophilic polyethylene glycol s...
Rice microbiome plays a critical role in the growth, health, stress tolerance, nutrient uptake, root development, and productivity of its host. In this study, advanced machine learning algorithms were applied to analyze the genomic data from 1365 rice-associated bacteria sourced from Bacterial an...
Rodrigues JM, Ferreira Leal AP, Buccini DF, Franco OL
Inflammatory bowel diseases (IBDs) are chronic disorders affecting the gastrointestinal tract, causing severe inflammation and tissue damage. Current treatments often have adverse effects, underscoring the need for alternatives. This article is a short review of host defense peptides (HDPs), whic...
International journal of medical sciences··PMID: 41209547
Adnan SB, Maarof M, Fauzi MB, Fadilah NIM
Wound healing is a complex and dynamic process that requires the coordination of cellular, molecular, and physiological events to restore tissue integrity. Despite notable advances in treatment strategies, optimizing healing outcomes, particularly in chronic wounds, remains a major challenge. Eme...
Conducting high-quality clinical research requires collaborative, interdisciplinary efforts, sustained institutional leadership, and adequate financial support - resources that are unfortunately insufficient across much of Latin America. This situation is no different in the field of clinical nut...
Neonatal brain injury is a major global health challenge, disproportionately affecting low- and middle-income countries (LMIC), where access to specialized care remains limited. Technology-driven neuroprotective strategies may allow the dissemination of specialized care to resource-constrained se...
Zeng K, Zhu Y, Han Z, Xiong S, Zhao Y, Xiao Z et al.
NLRP3 functions as a critical intracellular danger sensor for inflammasome activation, playing a crucial role in autoimmune diseases. Vitiligo progression has been linked to NLRP3, yet its specific involvement in melanocytes of vitiligo remains poorly understood. In this study, we demonstrate tha...
Vats N, Phadkule SS, Sarma S, Negi DS, Vishal B, Vadera SR et al.
This work reports a simple yet unique way of tailoring the morphology of M-type Strontium Hexaferrite, SrFe12O19 (SFO) particles inside the nanofibers. The reported materials were synthesized by the polymer-sol-assisted electrospinning technique followed by calcination. Calcination temperature an...
Rao KA, Khanna G, Bavishi H, Reddy NS, Mangukiya K, Jain R et al.
This study compared the efficacy and safety of two highly purified (HP) human menopausal gonadotropin (hMG) preparations, Gynogen HP and Menopur, in women undergoing controlled ovarian stimulation (COS) for in vitro fertilization (IVF). A multicenter, randomized, active-controlled noninferiority ...
Sung J, Ju SY, Park S, Jung WK, Je JY, Lee SJ et al.
Airborne particulate matter (PM) poses a major environmental risk that impairs skin health by triggering oxidative stress, inflammation, and cell death. In this study, we investigated the protective effects of Lysine-Proline-Valine (KPV)-an endogenous peptide derived from α-melanocyte-stimu...
Jeong HS, Choi Y, Kim DW, Je JY, Lee SJ, Choi CH et al.
Although oral delivery of therapeutic agents offers numerous benefits, its application is limited due to the digestive tract's harsh conditions (e.g., strong acidity and high osmolarity), which impair activity and create challenges in achieving targeted release into the intestine. Here, we presen...
Huang Y, Guan X, Zhang X, Yoosefian G, Ho H, Huang LT et al.
Purpose To evaluate the performance of a high-dynamic-range quantitative susceptibility mapping (HDR-QSM) cardiac MRI technique to detect intramyocardial hemorrhage (IMH) and quantify iron content using phantom and canine models. Materials and Methods A free-running whole-heart HDR-QSM technique ...
Chronic kidney disease (CKD) often leads to gut microbiota imbalance, accelerating disease progression and increasing uremic toxins and inflammation. We conducted a randomized clinical trial comparing outcomes between two multi-strain probiotic supplements Lobun Forte® (Sanzyme P Ltd, Hydera...
Zhang L, Li D, Aierken Y, Zhang J, Liu Z, Lin Z et al.
Cardiovascular disease (CVD) is a leading cause of death globally, and vascular calcification (VC) is an important independent risk factor for predicting CVD. Currently, there are no established therapeutic strategies for the treatment of VC. Although recognized combination therapies of nanomedic...
Amivantamab is an FDA-approved bispecific antibody targeting EGF and Met receptors, with clinical activity against EGFR mutant non-small cell lung cancer (NSCLC). Amivantamab efficacy has been demonstrated to be linked to three mechanisms of action (MOA): immune cell-mediated killing, receptor in...
Inflammatory bowel disease (IBD), as a chronic and recurrent inflammatory bowel diseases with limited therapeutic outcomes, is characterized by immune disorders and intestinal barrier dysfunction. Currently, the most medications used to cure IBD in clinic just temporarily induce and maintain remi...
The U.S. Food and Drug Administration’s (FDA) recent authorization of DermaSensor, an AI-enabled device for skin cancer detection in primary care, marks a pivotal moment in digital health innovation. Clinically, the authorization of the first AI-enabled device for use by non-specialists fo...
Orozco R, Borges G, Caldas-de-Almeida JM, Gutiérrez-García RA, Albor Y, Jiménez Pérez AL et al.
The longitudinal associations between DSM-5 Internet Gaming Disorder (IGD) and suicide-related ideation and behaviors have not been explored. In this study, we therefore seek to examine the association between baseline IGD and incident suicide ideation, plans, and attempts.This is a prospective c...
ACS applied materials & interfaces··PMID: 38289234
Li D, Shangguan J, Yu F, Lin G, Pan H, Zhang M et al.
The pathogenesis of ulcerative colitis (UC) is associated with the shedding of the gut mucus. Herein, inspired by the biological functions of mucus, growth factors-loaded in situ hydrogel (PHE-EK) was designed for UC treatment by integrating dihydrocaffeic acid-modified poloxamer as a thermosensi...
Split kidney function (SKF) is critical for treatment decision in pediatric patients with hydronephrosis and is commonly measured using renal scintigraphy (RS). Non-contrast-enhanced magnetic resonance urography (NCE-MRU) is increasingly used in clinical practice. This study aimed to investigate ...
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