Kisspeptin-54 Research

Li X, Liang C, Song G, Lin Y, Chen Y, Zhao J et al.

Long-term consumption of high-fat diet (HFD) leads to energy surplus, resulting in excessive adipose tissue (AT) accumulation and dysfunction. Kiss1 is known to play a role in the metabolic regulation of AT. To explore the involvement of Kiss1 in mediating the effects of energy surplus induced by...

Felicioni F, Nivia-Riveros JA, Caldeira-Brant AL, de Mérici Domingues E Paula T, Cardoso LC, Sales CF et al.

Proper fetal development depends on maternal nutrition. We investigated the placental morphofunctional adaptations to a low-protein diet, and their impact on fetal and newborn outcomes. Swiss mice were fed either normal (NPD, 20% crude protein, n=29) or low protein (LPD, 8% crude protein, n=26) d...

Pastor FM, Santos BR, Silva JF, Ocarino NM, Serakides R

Kisspeptins (Kp) play crucial roles in regulating reproductive functions. In recent decades, new effects of Kp on other systems, such as the cardiovascular, respiratory, and musculoskeletal systems, and its possible therapeutic effects on gestational hypothyroidism, diabetes mellitus, and neoplas...

Fang R, Carroll RS, Kaiser UB

Obesity and type 2 diabetes mellitus (T2D) are major risk factors for male hypogonadism, a disorder with multi-system impacts on health. However, the mechanisms underlying obesity-associated male secondary hypogonadism remain poorly understood. Here, we aimed to dissect dysfunction of the hypotha...

Hamutoğlu R, Kaloğlu C, Bulut HE, Yıldız Ç

Endometriosis is a common estrogen-dependent disease marked by ectopic endometrial growth. Although the PI3K/AKT and kisspeptin pathways are known to regulate endometrial homeostasis, their interplay in disease progression remains unclear. This study investigated the relationship between nuclear ...

Heyward FD, Pan H, Dreyfuss JM

Leptin receptor-expressing hypothalamic neurons (LepR Hypo ) are key regulators of energy balance, yet a comprehensive, cell type-resolved, chromatin accessibility map of these neurons is lacking. We profiled ∼20,000 LepR Hypo nuclei using single-nucleus multiome (snRNA-seq/snATAC-seq), id...

Habibi M, Mahmoudi F, Haghighat K, Khazali H

Polycystic ovary syndrome (PCOS) is a common endocrine disorder and a major cause of infertility in women. Although studies have reported the effects of naringenin on PCOS; the underlying molecular mechanisms remain unclear. This study aimed to investigate the effect of naringenin on the expressi...

Wu C, Jiang H, Xu W, Li B, Zhang H, Zhang L et al.

Emerging evidence highlights the pivotal role of KISS1 in cancer metastasis; however, there remains a dearth of pancancer analyses, particularly concerning immunotherapy. Here, we conducted a comprehensive investigation of KISS1 across various cancers, with a specific focus on breast cancer, usin...

Mo T, Qiu Y, He S, Wang G, Li B, Shen Q et al.

Polycystic ovary syndrome (PCOS) and mental health disorders have high rates of co-occurrence. Although the precise pathophysiological mechanisms remain unknown, the observed changes in those conditions may be modulated by kisspeptin (Kiss1), a protein that regulates energy metabolism.The aim of ...

Silva JDN, de Sousa LMM, de Sousa ME, Vieira HR, Alves GA, Neifert NT et al.

Neurons in the arcuate nucleus of the hypothalamus (ARH) that coexpress kisspeptin, neurokinin B, and dynorphin (KNDy neurons) are considered the gonadotropin-releasing hormone (GnRH) pulse generator necessary for fertility. KNDy neurons are also metabolic sensors controlling the hypothalamic-pit...

Li Q, Wang J, Wang Y, He P, Zhang L, Hu J et al.

The hypothalamus orchestrates transitions in maternal reproductive states through dynamic neuroendocrine-metabolic network remodeling, optimizing maternal-fetal resource allocation during gestation and facilitating postpartum reproductive recovery. These transitions entail significant alterations...

Talukdar C, Choudhary SS, Talukdar PM, Borah MS, Baishya AC

Polycystic ovary syndrome (PCOS) is one of the most common endocrine and metabolic disorders affecting women of fertile age. Its etiology is multifactorial and presumed to have a genetic basis along with environmental factors. Kisspeptins are peptide products produced from the KISS1 gene, which c...

Putteeraj M, Soga T, Parhar IS

A complex network exists between the reproductive, circadian and the serotonergic system. Modulation of brain serotonin levels triggers sexual irregularities and alters circadian behaviour. This study investigated the presence of an endogeneous clock within kisspeptin neurons in the anteroventral...

Kong L, Yushanjiang S, Nie L, Pan Y, Jin L, Wang Z et al.

Endometriosis (EMs) is a common gynecological disorder. According to the most widely recognized theory of retrograde menstruation, endometrial cells require completion of three key steps during ectopic implantation: adhesion, invasion, and angiogenesis. Although kisspeptin exerts anti-invasive an...

Sarman E, Asci H, Selcuk E

This study aimed to investigate the immunohistochemical expression patterns of proliferating cell nuclear antigen (PCNA), heat shock protein-70 (HSP-70), and kisspeptin-1 (KISS-1), as well as the gene expression levels of nuclear factor erythroid 2-related factor 2 (NRF2), heme oxygenase-1 (HO-1)...

Song W, Dai T, Yang D, Li S, Cao M, Dan X et al.

Kisspeptin, encoded by Kiss1 gene, regulates reproduction via the hypothalamic-pituitary-gonadal axis. While kisspeptin treatment promotes follicular development in Tan sheep, its direct action on ovarian granulosa cells remains unclear. For this, we first detected the expression of Kiss1 and its...

Nguyen CM, Sallam M, Huynh MA, Yu Y, Nguyen NT, Ta HT et al.

Preeclampsia is a leading cause of maternal and fetal morbidity, with altered placental function being a key contributor to its pathogenesis. Extracellular vesicles (EVs) derived from the placenta have emerged as promising biomarkers for early diagnosis of preeclampsia. However, current EV isolat...

Xie T, Qin W, Zeng D, Wang R, Chen S, Chen Y et al.

Controversy exists regarding the relationship between obesity and pubertal onset in boys, and the underlying mechanisms remain unclear.To establish a high-fat diet (HFD)-induced obesity model in juvenile male Sprague-Dawley (SD) rats, and to investigate the relationship between obesity and pubert...

Decourt C, Heads K

Miscarriage, defined as spontaneous pregnancy loss before 20 weeks of gestation, affects 10-15% of pregnancies in women under 30, rising to over 50% in women over 45. Implantation failure and early placental dysfunction are major contributors, yet the precise mechanisms remain incompletely...