Kisspeptin-10 Research

Guedes BN, De Oliveira Neto JG, Zielińska A, Santini A, Andreani T, Oliveira MBPP et al.

A new micellar delivery system for the dual loading of resveratrol and rutin (RES-RU-micelles) is described and characterized. Analyzes were carried out to determine the size parameters (mean particle size and polydispersity index) and surface electrical charge, 24 h after production and a...

Pastor FM, Santos BR, Silva JF, Ocarino NM, Serakides R

Kisspeptins (Kp) play crucial roles in regulating reproductive functions. In recent decades, new effects of Kp on other systems, such as the cardiovascular, respiratory, and musculoskeletal systems, and its possible therapeutic effects on gestational hypothyroidism, diabetes mellitus, and neoplas...

Shah H, Mohan AM, Shah R, Mehta D, Ramachandran AV, Pandya P et al.

Glioblastoma multiforme (GB) is the most aggressive and lethal primary brain tumor, with limited biomarkers for diagnosis and therapeutic targeting. This study aimed to investigate the regulatory effects of Kisspeptin-10 on epithelial-mesenchymal transition (EMT) and apoptosis in GB by integratin...

Kalkan ÖF, Erdem Ş, Erdem M, Ateşer Kalkan S, Şahin Z, Uzun AY et al.

Microglial NLRP3 inflammasome activation plays a central role in the neuroinflammatory cascade that contributes to the pathogenesis of various neurodegenerative diseases. Activation of the canonical inflammasome pathway leads to caspase-1 activation, gasdermin D (GSDMD) cleavage, and pyroptotic c...

Zhao R, Nie L, Shi Y, Jin L, Pan Y, Zhang X et al.

Hepatocellular carcinoma is a leading cause of cancer-related mortality worldwide, with metabolic syndrome emerging as a major risk factor. However, the molecular mechanisms underlying the association between metabolic syndrome and hepatocellular carcinoma progression are not fully understood. He...

Sridhar A, Khan D, Muthukumar R, Sampathkumar S, Irwin N, Flatt PR et al.

Kisspeptin is a neuropeptide recognised for a pivotal role within the reproductive system, but potentially important endocrine metabolic effects are less well understood. We examined effects of twice-daily intraperitoneal administration of saline vehicle or kisspeptin-10 (25 nmol/kg), for 21 days...

Shah H, Mohan AM, Buch L, Ramachandran AV, Pandya P

Triple-negative breast cancer (TNBC) is an aggressive subtype lacking ER, PR, and HER2 receptors making it highly clinically challenging subtype pf breast cancer. In this study, we investigated the effect of exogenous Kisspeptin-10 (Kp-10), on MDA-MB-231 and MDA-MB-468 cells. TNBC cells using bot...

Li L, Guo Y, Zhao K

The integrity of the Blood-Brain Barrier (BBB) is crucial in the pathophysiological progression of acute ischemic stroke (AIS). However, the potential of Kisspeptin-10 (Kp-10), with its antioxidant and anti-inflammatory properties, has not been explored experimentally in the context of stroke man...

Li J, Chen J, Lu L, Gan B

Gestational diabetes mellitus (GDM) is a common pregnancy complication that leads to insulin resistance (IR) and adversely affects both maternal and fetal health. Kisspeptin-10 (Kp-10), a peptide acting via G Protein-Coupled Receptor 54 (Gpr54), has shown potential in modulating insulin secretion...

Shah H, Pillai P, Buch L, Ramachandran AV, Pandya P

Metastasis is a key hallmark of cancer aggressiveness, particularly in triple-negative breast cancer (TNBC), which lacks effective targeted therapies. Kisspeptin-1 (KISS1), a known metastasis suppressor is emerging as a potential therapeutic modulator. This study investigates the structural and r...

Bozkurt G, Agaoglu AR, Aslan S, Wehrend A, Cortu A, Tepik FZ et al.

This study aimed to evaluate the effects of Kisspeptin (KP-10) and Cabergoline (CB) on hormonal regulation in anestrus female dogs. Twenty-three clinically healthy anestrus female dogs were randomly allocated into five treatment groups. Group 1 (G1, n = 4) received CB with saline; Group...

Yan W, Liang J, Liu M, Hu X, Zhang H, Guo J et al.

Neonatal bloodstream infections (BSIs) caused by extended-spectrum β-lactamase Enterobacterales (ESBL-E) are associated with high rates of morbidity and mortality. This study aimed to describe the clinical characteristics, profiles of antibiotic susceptibility, and risk factors associated w...

Cheng C, Xiong D, Zheng F, Wang T, Li W

This study investigated the effects of Kisspeptin-10 (Kp-10) on HIV-1 Tat-induced blood-brain barrier (BBB) permeability and oxidative stress using both in vivo and in vitro models. In vivo, one hour after intraperitoneal administration of 50 nmol/kg (DSS)*6-Kp-10, mice were intravenously injecte...

Wang T, Lu W, Cheng Z, Wang L, Jiang Z, Yue Y et al.

Wilson's disease (WD), as a typical disease of excessive Cu2+ deposition, is characterized by disorders of copper metabolism in the brain and thereby damaging the reproductive system. Conventional interventions using copper chelators can temporarily reduce intracellular copper (in-copper), but co...

Günday ÖK, Vurmaz A, Yılmazer M

We aimed to evaluate the usefulness of serum kisspeptin (KP), measured in the 1st trimester (11-14 weeks), as a new biomarker that can predict antenatal complications.A prospective case-control study of prospectively collected data. Blood samples of all patients (N = 124) were preserved at -70 &#...

Szysiak N, Kosior-Korzecka U, Greguła-Kania M, Patkowski K, Fila M, Junkuszew A et al.

Neurokinin B (NKB), dynorphin A (Dyn A) and kisspeptin (KiSS) are key agents that participate in the neuroendocrine regulation of the development and functioning of the reproductive system. While the role of KiSS is better understood, the functions of NKB and Dyn A at the pituitary level have not...

Gimeno-Martos S, Gómez-León A, Luigia B, Lorenzo PL, María AÁ, Rosa María GG et al.

Mammalian reproductive function is regulated by hypothalamic neurons that secrete Kisspeptin (Kp), a neuropeptide that stimulates gonadotropin-releasing hormone (GnRH) secretion, triggering pituitary gonadotrophins (LH and FSH) and gonadal steroids. This study evaluated the effect of Kisspeptin-1...

Qiu J, Chen G, Peng G, Qu G, Ren T, Deng J et al.

In Osteoarthritis (OA), the senescence of chondrocytes plays a pivotal role, contributing to cartilage degradation and impairing tissue repair mechanisms. (Kp-10), a peptide hormone, exerts diverse biological functions across multiple cell types and tissues via its receptor Gpr54. However, its ro...

Yu H, Xie M, Liufu X, Xu Y, Chen L

Cerebral aneurysms (CAs) are a prevalent brain condition with poorly understood pathological features. The Kisspeptin-10 (KP-10)/G protein-coupled receptor 54 (GPR54) system is a vital neuroendocrine pathway primarily implicated in the regulation of reproductive functions and energy metabolism. T...

Marino M, Di Pietro P, D'Auria R, Lombardi M, Pastorino GMG, Troisi J et al.

Neurogenesis is considered the most robust form of plasticity in the adult brain. To better decipher this process, we evaluated the potential crosstalk of Kisspeptin and Endocannabinoid Systems (KPS and ECS, respectively) on hippocampal neurogenesis. Male adolescent rats were exposed to kisspepti...