Insulin Research

Iruela-Arispe ML

Papa A, Balzan S, Lubrano V, Sabatino L

Atherosclerosis and diabetes are largely recognized as inflammatory disorders underlying cardiovascular disease. C-reactive protein, interleukin-6 and fibrinogen constitute the most established inflammatory biomarkers in clinical practice for the characterization of individuals affected by athero...

Zhao H, Chen JL, Gao Y, Luo J, Rao Z, Muntaner C et al.

Diabetes distress significantly contributes to depressive symptoms in children with type 1 diabetes (T1D). Few studies have examined the bidirectional contributions of both parents' and children's diabetes distress to their own (actor effect) and each other's (partner effect) depressive symptoms ...

Wilson KJ, Esteban-Lopez M, Myhr C, Ye W, Moore CE, Southall N et al.

A dose-response quantitative high-throughput screening of 147,334 small molecule compounds using a human Relaxin/Insulin-like Family Peptide Receptor 2 (RXFP2)-transfected HEK293T-RXFP2 cell line identified compound 5 with modest Insulin-Like3 (INSL3) agonist activity. An extensive structure-acti...

Jiang XY, Chen DW, Duan T, Zhang JD, Ren YP, Tan J et al.

Fetal overgrowth, manifesting as large for gestational age or macrosomia, remains a common complication of gestational diabetes mellitus (GDM) with neonatal and long-term metabolic implications. While maternal hyperglycemia is a key driver, evidence describes the role of dysregulated placental nu...

Karaoglu IC, Odabas A, Önder T, Kizilel S

β-Cell replacement therapy offers a potential cure for type 1 diabetes, but its success is limited by rapid graft rejection. While genome-wide CRISPR screens have recently identified RNLS and HIVEP2 as candidate genes capable of protecting β-cells from autoimmune destruction, their ef...

Shakir Z, Pandey A, A Alsayegh A, Fahad Alshahrani A, Ashfaq F, Khan M et al.

Gestational diabetes mellitus (GDM) is hyperglycaemia first identified during pregnancy. Because GDM and type 2 diabetes mellitus (T2DM) share insulin resistance and β-cell dysfunction, T2DM variants may also influence the risk of GDM. This study examined the association of three genome-wid...

Pender SC, Khoodoruth MAS

In Canada, nearly one in five children present with diabetic ketoacidosis (DKA) at the time of their first diabetes diagnosis, a serious and potentially life-threatening complication. Adolescence, marked by insulin resistance, fluctuating appetite, and increasing independence, presents unique cha...

Qiao Y, Zhou F, Mao T, Gao L

Glucose-dependent insulinotropic polypeptide (GIP), once the overlooked sibling of the incretin family, is now experiencing a research renaissance. Historically, its therapeutic development was hindered by a seemingly diminished insulinotropic effect in type 2 diabetes (T2DM), its paradoxical sti...

Zhou L, Wu H, Wu T, Wang X, Song E, Su F et al.

To examine the associations between platelet parameters and metabolic syndrome (MetS) and to explore their relationships with insulin resistance (IR).This cross-sectional study included approximately 570,000 adults who underwent health examinations at the Health Management Center of the First Aff...

Duque-Cordoba PA, Diaz-Ordoñez L, Carvajal-Del-Castillo L, Marmolejo D, Leal AF, Pachajoa H et al.

Familial partial lipodystrophy type 2 (FPLD2), or Dunnigan syndrome, is a rare autosomal dominant disorder caused by mutations in the lamin A (LMNA) gene, most frequently involving the p.R482W variant. It is characterized by regional loss of subcutaneous fat and severe metabolic abnormalities, pa...

Guo S, Li Y, Yang Y, Jiang Y, Wang Y, Cao Y et al.

Diabetes mellitus poses a global health burden with limited therapies derived from breast milk targeting its systemic complications. Probiotics like Lactobacillus helveticus show metabolic benefits, but strain-specific efficacy and mechanisms remain unclear.This study evaluated L. helveticus WIS0...

Isawi IH, Al-Sawalha NA, Mahmoud F, Al-Khawaldeh I, Alzoubi KH

Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a relatively new class of antidiabetic agents that lower blood glucose independently of insulin by inhibiting renal SGLT2 in the proximal tubule, thereby increasing urinary glucose and sodium excretion. Empagliflozin (Empa), an FDA-approved SG...

Razmi S, Moshtaghie AA, Seyedabadi M, Hashem N, Akbarzadeh S

Exercise-induced ionic changes can modulate the interaction between liraglutide and the glucagon-like peptide-1 receptor (GLP-1R). To investigate this, molecular dynamics simulations and in vivo experiments using streptozotocin-induced diabetic rats were performed. Under exercise-mimicking ionic ...

Wang Y, Luo Z, Zhou Z, Zhang X

Dyslipidemia is a major contributor to cardiovascular disease. The C-reactive protein - triglyceride - glucose index (CTI), which reflects insulin resistance and systemic inflammation, has increasingly been recognized as a potential marker for metabolic disturbances. However, its predictive value...

Goulart JB, Kargl CK, Sterczala AJ, Sekel NM, Wunderlich LG, Mroz KH et al.

Optimizing bone mass accrual early in life is a strategy for mitigating fracture risk in older age.This study aimed to identify factors associated with lower than expected bone mass in healthy young adult men.Data from 39 male participants (21 areal bone mineral density [aBMD] Z scores <-1.0 a...

Su C, Cui Z, Guo J

Cerebral small vessel disease (CSVD) is a leading cause of stroke and vascular cognitive impairment, but its metabolic determinants are not fully understood. Emerging evidence indicates that insulin resistance (IR) plays a crucial role in CSVD through vascular, inflammatory, and oxidative mechani...

Hagan J, Griffin TP, Chauhan R, Choudhary P, Crabtree TSJ, Ackroyd D et al.

The NHS England hybrid closed-loop (HCL) insulin pump pilot offered people living with Type 1 diabetes (PWT1Ds) access to HCL therapy. Outcomes demonstrated the glycaemic benefits of HCL. Our study explored the views, experiences and impact of HCL on users and their partners' daily life.A total o...

Thewjitcharoen Y, Chatchomchuan W, Wanothayaroj E, Butadej S, Nakasatien S, Himathongkam T et al.

People with diabetes mellitus (DM) remain at high risk of cardiovascular (CV) disease. The use of coronary artery calcium (CAC) has been demonstrated as the most powerful CV risk indicator and surrogate marker for the overall vascular health in the asymptomatic population.This study aimed to find...

Yang Y, Liu Y, Zhang GJ

Retraction Notice: It appears that the authors have taken credit for research conducted by other scientists, and the paper is therefore being retracted. Reference: YuXin Yang, Yantong Liu, Gui-Ju Zhang. Xiehuang San Extract Attenuates Insulin Resistance in Obese Rats via Gut Microbiota Modulation...