The World Allergy Organization journal··PMID: 41674578
Ma H, Zheng D, Wang Y, Tian C, Huang Z, Xiong S et al.
Hereditary angioedema (HAE) is a rare, severe, disabling, and life-threatening disorder characterized by recurrent and unpredictable edema of skin and mucous membranes. Gastrointestinal edema, often presenting as abdominal pain, is common but frequently misdiagnosed, leading to unnecessary surger...
Shinjo-Nagahara S, Hiratsuka G, Okada Y, Kitano Y, Chiba K
Electrochemical peptide synthesis using triaryl phosphines has been shown to be a promising approach for reducing the amount of waste in peptide synthesis. However, there is room for improvement from the viewpoint of the substrate scope. In this research, we succeeded in improving the reaction ef...
Background: This study aimed to comprehensively define the clinical profile of elderly patients with hereditary angioedema (HAE) caused by C1 esterase inhibitor (C1INH) deficiency and/or dysfunction (HAE-C1INH). Furthermore, it sought to reveal age-related differences in disease expression and ma...
Pulitanò R, Misiti FR, Isidori L, Giudice M, La Verde F
Hereditary angioedema (HAE) is a rare condition characterized by episodic subcutaneous or mucosal edema, which may pose significant challenges in the perioperative setting. We report the management of a 79‑year-old male patient undergoing transurethral resection of a bladder tumor under ge...
Type II hereditary angioedema (HAE) is a rare and underrecognized condition. Early diagnosis and family screening are essential to prevent life-threatening attacks.A 36-year-old woman presented with recurrent facial swelling and dysphagia unresponsive to standard treatments.Laboratory analysis re...
Bradykinin is a nonapeptide derived from the cleavage of circulating kininogens by plasma or tissue kallikreins and is endowed with powerful pharmacologic actions, such as the production of protein-rich exudates and vasodilation. The widely expressed B2 receptor for bradykinin (a G protein-couple...
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics··PMID: 41547653
Xu D, Jiang C, Ge C, Zhang T, Wang J, Wang H et al.
Exogenous plasma kallikrein 1 (KLK1) supplementation is hypothesized to have both immediate and long-lasting actions that may improve outcomes following acute ischemic stroke. ZHB103, a polyethylene glycol (PEG)-modified long-acting recombinant human KLK1 (LA-rhKLK1), has been developed as a cand...
González-Bravo L, Barbarroja-Escudero J, Laiseca-Antón A, Álvarez-Mon M, Matas-Domínguez T, Monjo-Paz J et al.
Alteplase is a recombinant tissue plasminogen activator (rt-PA), used for intravenous thrombolysis in ischaemic strokes. Orolingual angioedema is a rare but potentially lifethreatening complication of alteplase. Concomitant treatment with angiotensin-converting enzyme (ACE) inhibitors has been id...
de Lara JD, Vidal T, de Souza JB, Kodavara E, Decker ER, Grotto FS et al.
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) disrupts multiple host regulatory systems, including the kallikrein-kinin system (KKS), which plays a central role in vascular homeostasis and inflammation. Following viral entry, angiotensin-converting enzyme 2 (ACE2) is internalized a...
International journal of emergency medicine··PMID: 41339791
Dungan LS, Khalib K, Curley D, Keogan M
Hereditary angioedema (HAE) affects 1.22 people per 100,000 worldwide, and can cause fatal airway obstruction due to laryngeal oedema. Diagnosis is often delayed by several years, due to rarity, and similarity to more common histamine-mediated angioedema. Approximately 20-25% of cases have a de n...
Bocquet A, Bouillet L, Hardy G, Boccon-Gibod I, Deroux A, Arnaud M et al.
The diagnosis of hereditary angioedema with a normal C1Inh was genetic. The two most frequent pathogenic variants are found in the FXII and PLG genes. Their management is similar to that of HAE patients with C1Inh deficiency but without evidence-based medicine.The French Reference Centre for Angi...
Du W, Meng Z, Yang K, Zhang Q, Lin X, Zhang W et al.
Hereditary angioedema (HAE) remains significantly underdiagnosed and misdiagnosed in China, with laryngeal involvement leading to high mortality rates, creating an urgent need for exploring feasible diagnostic and management approaches in resource-limited settings.To establish and evaluate a comm...
Sánchez ML, Robinson P, Italia Z, Hoang T, Muñoz M, Coveñas R et al.
The current known data on the involvement of the peptidergic systems in breast cancer progression is overwhelmingly vast. Peptidergic systems are useful tools for imaging, diagnosis, prognosis and treatment of breast cancer. These systems play a crucial role in both basic and clinical breast canc...
Kotani S, Mishima Y, Kishimoto K, Oka A, Oshima N, Kawashima K et al.
Post-infectious irritable bowel syndrome (PI-IBS) is a functional gastrointestinal disorder that develops after intestinal infection. A follow-up study after a waterborne outbreak of gastroenteritis indicated involvement of specific genetic variants including toll-like receptor (TLR)9, although i...
Distinguishing between anaphylaxis and bradykinin-mediated angioedema can be difficult in the acute setting, particularly when airway compromise dominates the presentation. Recognition is crucial, as management strategies differ substantially. An 84-year-old woman presented to the Emergency Depar...
We describe a 62-year-old female patient who presented to the Accident & Emergency (A&E) department with upper airway edema. Her past medical history included hypertension, obstructive sleep apnea, and ischemic heart disease. She had been previously hospitalized for a lower resp...
Hereditary angioedema (HAE) is a rare disorder characterized by recurrent, non-pitting edema affecting the mucosal, submucosal, or subcutaneous tissues. A rarer subtype, HAE with normal C1 esterase inhibitor (HAE-nC1-INH), lacks universally accepted biomarkers.  We present a 48-year-old male...
Sahwan O, Jamal F, Elshaer A, Batha L, Shahin T, Pham MM et al.
Sjögren's syndrome (SS) is a chronic autoimmune disorder characterized by lymphocytic infiltration and destruction of exocrine glands, commonly involving the salivary and lacrimal glands, leading to dry mouth and eyes. While SS primarily affects the upper gastrointestinal tract, this case pr...
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