Humanin Research

Miles KG, Dorobantu DM, Douwes JM, Frank BS, Jone PN, Muthurangu V et al.

Right ventricular (RV) failure is a principal determinant of morbidity and mortality in children with pulmonary hypertension, making accurate RV assessment a cornerstone of risk stratification and long-term management. Noninvasive imaging plays a central role in this evaluation; however, commonly...

Okoye I, Shah AA, Zahra U

Internal jugular vein thrombosis (IJVT) is an uncommon but potentially life-threatening condition, arising from diverse risk factors including infection, instrumentation, and malignancy. Although its incidence in head and neck (H&N) cancers remains low, early recognition is essential, as seri...

Johnson DB, Nassar AH, Aijaz A, Knight A, Zerey MM, Rini BI et al.

Anti-PD-L1 antibodies have transformed cancer treatment and are increasingly being used in patients with early-stage malignancies including in the adjuvant and neoadjuvant settings. In certain cancers, earlier administration of these agents reduces the risk of metastatic disease and might improve...

Toyomoto R, Furukawa TA, Noma H, Tajika A, Watanabe M, Honda Y et al.

Perinatal depression poses substantial risks to both mothers and their offspring. Given its chronic and recurrent nature, developing effective prevention strategies is crucial. Internet-based cognitive-behavioural therapy (iCBT) has shown promise. However, the efficacy of specific CBT skills and ...

Xuan L, Yang W, Luo X, Xiong S, Yang S, Si Y et al.

Hyperuricemia (HUA) is a growing global health issue driven by economic development and lifestyle changes. Approximately 75% of uric acid in humans is excreted renally. Excess uric acid deposits in renal tissues, promoting tubulointerstitial fibrosis and leading to hyperuricemic nephropathy (HN),...

Boopathi PA, Singh S, Roy P, Tahbildar S, Kochar SK, Kochar DK et al.

vir genes, a multigene family in Plasmodium vivax that are a part of a larger superfamily of genes called the pir (Plasmodium interspersed repeat) genes, have been reported earlier to be potentially involved in cyto-adherence and evasion of splenic clearance. Plasmodium vivax, historically charac...

Rickard M, Khondker A, Dos Santos J, Maher S, Nzeyimana I, Dhalla R et al.

Antenatal hydronephrosis (HN) is the most common congenital urinary tract abnormality, but management is controversial. Current guidelines recommend continuous antibiotic prophylaxis (CAP), voiding cystourethrogram (VCUG), and diuretic renal scintigraphy (DRS) for high-grade HN, yet these measure...

Ma R, Zhong L, Lin D, You Z, Luo X, Lin X et al.

Childhood trauma is associated with a more severe clinical course in bipolar disorders; however, the latent profiles of childhood trauma and their differential impacts on cognitive functioning and quality of life remain underexplored.Using latent profiles analysis, 275 bipolar patients were categ...

Rault TM, Clees S, Merrell DP, Hanson RK

The pyrolysis kinetics of NH3 and NH3-relevant radicals are of importance for the implementation of NH3 as a fuel. The pyrolysis of NH2 radicals was therefore studied behind reflected shock waves using 7-243 ppm of N2H4 to generate NH2 in bath gases of Ar and N2. Post-shock conditions spanned 290...

Mo Q, Qin M, Liang H, Wei L, Li Y, Qin Y et al.

Hyperuricemic nephropathy (HN) is a worldwide metabolic disorder marked by uric acid (UA) imbalance and renal tubulointerstitial fibrosis, yet therapies that both lower UA and prevent fibrosis remain limited. Targeting the gut-kidney axis with probiotics is a promising strategy, but most candidat...

van Wesemael AJ, Klomp K, Malinowska AM, van Kaam AH, de Meij TGJ, Belzer C et al.

After birth, antibiotics are frequently administered to preterm infants for suspected early onset sepsis (EOS). Early empiric antibiotic exposure (EEAE) may disrupt the gut microbiota of preterm infants. This study investigates the association between EEAE duration and gut microbiota dynamics in ...

Xin Y, Yang L, Liu C, Li D, Liu Y, Liu Y et al.

Head and neck squamous cell carcinoma (HNSCC) exhibits heterogeneous tumour-immune microenvironments that limit the utility of single biomarkers such as programmed death-ligand 1 (PD-L1) and tumour mutational burden (TMB) for guiding immune checkpoint inhibitor (ICI) therapy. This study developed...

Yin XH, Zhang HY, Cui ZH

BenHn rings, isoelectronic with boron rings, offer a promising platform for designing unusual bonding patterns and unique geometries. Here, we report the first BenHn-based inverse-sandwich complexes. Potential energy surface analyses of M2Be6H6 (M = N, P, As, Sb, or Bi) show that Sb2Be6H6 and Bi2...

Singh G, Singh C, Singh A

Huntington's disease (HD) is a progressive neurodegenerative disorder characterized by motor dysfunction, cognitive decline, and psychiatric disturbances. It is caused by the abnormal expansion of cytosine-adenine-guanine triplet repeats in the HTT gene, leading to the production of mutant huntin...

Balziano S, Margalit I, Kollender R, Yahav D, Freidlander A, Prat D et al.

Fever often delays urgent hip fracture surgery due to infection concerns. This study found that operating early, despite fever, did not increase complications or death compared to waiting. Thus, early surgery appears to be a feasible option for selected patients, avoiding the risks associated wit...

Takeji Y, Taniguchi T, Morimoto T, Shirai S, Kitai T, Tabata H et al.

The overall impact of the introduction of transcatheter aortic valve replacement (AVR) on the prognosis of the entire population with severe aortic stenosis has not been evaluated.We analyzed 2 multicenter registries that consecutively enrolled patients with severe aortic stenosis before and afte...

Zhou S, Gorroño J, Roger J, Irakulis-Loitxate I, Lindstrot R, Pei Z et al.

The Flexible Combined Imager aboard the Meteosat Third Generation satellite (MTG-FCI) provides geostationary observations over Europe and Africa, the Middle East, parts of South America, and the surrounding waters. The FCI samples the visible, near-infrared, and shortwave infrared spectral window...

Kamrul-Hasan ABM, Shaikh S, Ashraf H, Kuchay MS, Nagendra L, Dutta D et al.

Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are widely used in managing type 2 diabetes (T2D). A significant number of these patients choose to observe religious fasting during Ramadan. Although existing guidelines recommend caution when administering SGLT2i during Ramadan due to potential...

Tang W, Li A, Austin TR, Brækkan SK, Nøst TH, Li X et al.

Venous thromboembolism (VTE) is a leading cardiovascular disease, yet its etiology is incompletely understood. This study used large-scale, high-throughput aptamer-based proteomics to identify new circulating protein biomarkers and biological pathways for incident VTE.We included 4 longitudinal c...

Gouveia Z, Paled Y, Rahiminejad R, Finer Y, Santerre P

To compare a non-ester methacrylate-alternative dental resin (ER) with conventional ester-based methacrylate resin (MAR) in terms of (i) susceptibility to degradation by human neutrophils (hN), (ii) influence on hN pro-inflammatory phenotypes, and (iii) modulation of Streptococcus mutans (SM) vir...