Goserelin Research

Tran B, Yeh N, Gayle A, Holmes E, Hu J, Damineni S et al.

An understanding of how androgen deprivation therapy (ADT) prescribing patterns impact patient outcomes in a real-world setting is needed to help inform treatment decisions and improve the care of patients with prostate cancer (PCa). REASSURE was a retrospective, observational study that describe...

Tang Y, Cai Y, Jiang X, Qiao R, Gao Z

The aims of this study were to report an exceptionally rare case of de novo small cell neuroendocrine carcinoma of the prostate (SCNEPC) presenting with unprecedented prostate-specific antigen (PSA) elevation and Gleason score 5 + 5, and to describe the remarkable treatment response achieved with...

Sandhu K, Wells C, Newton MMH, Murphy DG, Lawrentschuk N, Perera ML et al.

Androgen deprivation therapy (ADT) has been pivotal in advanced prostate cancer (PCa) for decades. The introduction of androgen-receptor pathway inhibitors (ARPIs) has transformed treatment paradigms. However, their real-world adoption over time has not been comprehensively characterised. We exam...

Subha S, Skelly D, Jenkins D

Posterior reversible encephalopathy syndrome (PRES) is an acute neurological disorder characterised by seizures, altered mental status and visual disturbances. Common triggers include hypertension, renal impairment and immunosuppressive therapy. Blood transfusion and gonadotropin-releasing hormon...

Engebrethsen C, Yndestad S, Rasmussen ME, Janssen EAM, Gilje B, Blix ES et al.

While neoadjuvant endocrine therapy (NET), with or without a CDK4/6 inhibitor, is an established treatment option for estrogen receptor-positive breast cancers, optimal patient selection and second-line treatment for non-responders remain uncertain.In the open-label, phase 2 PETREMAC trial (NCT02...

Pérez-López OI, Lendinez-Sanchez G, González-García J, Jiménez-Rodríguez B, Leon-Fradejas M, Fernandez-Garay D et al.

Visceral crisis in hormone receptor-positive (HR+), HER2-negative metastatic breast cancer poses a therapeutic challenge, traditionally managed with chemotherapy due to the urgency of organ dysfunction. However, recent evidence suggests that cyclin-dependent kinase 4/6 inhibitors (CDK4/6i), in co...

Anastasilakis DA, Anastasilakis AD, Gkiomisi A, Semertzidis A, Nikolakopoulos P, Papachatzopoulos S et al.

Xiao Z, Zhang X, Zhang L, Li Y, Ma S

Goserelin is widely used for prostate cancer, but drug-induced liver injury (DILI) has been rarely reported. We present a patient who developed ALT/AST elevations after each subcutaneous injection, followed by improvement after withdrawal and hepatoprotective therapy, with positive rechallenge up...

de Rosas-Valera M, Lechuga JCP, Yapchiongco LRS, Juat NS, De Rosas-Labitigan MJ, Amarillo MLE et al.

The aim of the study is to estimate the cost of breast cancer diagnosis, treatment, and management in the Philippines. Specifically, it aims to identify the resource requirements and interventions related to breast cancer diagnosis, treatment, and management, measure resource volumes (number of u...

Al-Bitar A, Nasra AB, Alsaoub L, Aldakak MA, Saifo M

Synchronous bilateral breast cancer (SBBC) is rare, comprising 2-5% of all breast cancer cases. Even more uncommon is the presence of discordant histologies in each breast. This report discusses a case involving invasive ductal carcinoma (IDC) in the left breast and invasive lobular carcinoma (IL...

Crown J, Stroyakovskii D, Yardley DA, Huang CS, Fasching PA, Bardia A et al.

At the primary efficacy analysis of the NATALEE phase III trial, ribociclib plus a nonsteroidal aromatase inhibitor (NSAI) demonstrated a statistically significant improvement in invasive disease-free survival (iDFS) versus NSAI alone in patients with hormone receptor (HR)-positive/human epiderma...

Sánchez ML, Robinson P, Italia Z, Hoang T, Muñoz M, Coveñas R et al.

The current known data on the involvement of the peptidergic systems in breast cancer progression is overwhelmingly vast. Peptidergic systems are useful tools for imaging, diagnosis, prognosis and treatment of breast cancer. These systems play a crucial role in both basic and clinical breast canc...

Friedrich NA, Janes JL, Parrish J, De Hoedt AM, Josan K, Tatonetti NP et al.

Androgen deprivation therapy (ADT) for prostate cancer (PC) has been linked to adverse events, such as cardiac events and osteoporosis. Whether these associations differ by race is unknown.To assess the association between ADT and time to cardiovascular and bone-related adverse events across raci...

Han Q, Jiao Y, Cai R, You J, Chen X, Zhang W et al.

Goserelin is widely employed as a form of androgen deprivation therapy in the management of prostate cancer. Given the chronic nature of hormonal therapy, sustained and long-term drug administration is essential to ensure therapeutic efficacy. Goserelin is often formulated as sustained-release im...

Kieu MTT, Le MH, Nguyen CP

Endometriosis-related dysmenorrhea and pelvic pain impose significant economic and quality-of-life burdens. This study evaluated the cost-effectiveness of dienogest compared to gonadotropin-releasing hormone agonists (GnRH-a) for managing dysmenorrhea and pelvic pain in Vietnam.The cost-effective...

Wang X, Wang L, Sun K, Gao Y, Wei L, Duan Z et al.

Prostate cancer, a common malignancy in the male population, is typically characterized by urinary symptoms, such as urinary obstruction and frequency. This report presents a rare case of metastatic prostate cancer that initially manifested with recurrent melena.A 70-year-old man with recurrent m...

Xiong Y, Huang W, Wang C, Ma W, Jin S, Lin J et al.

Endometriosis (EMs) is a common gynaecological condition with high recurrence rates after fertility-preserving laparoscopic surgery, and optimal postoperative medical treatment remains unclear.To evaluate the efficacy and safety of various postoperative medical treatments in reducing recurrence, ...

Shi YJ, Yang YS, Ren DB, Jing W

Oesophageal cancer is the seventh leading cause of cancer mortality worldwide. Prostate cancer metastasis to the oesophagus is exceedingly rare. We report an 82-year-old male patient. He presented to the gastroenterology clinic complaining of increased bowel movement frequency from baseline. The ...

Peng G, Liang Z, Zuo F, Li J, Han F, Zhang B et al.

Existing research indicates that bicalutamide and zoladex show significant potential in treating prostate cancer. However, in the clinical application of treating benign prostatic hyperplasia (BPH), it is limited due to relatively severe side effects, and the specific mechanism of action has not ...

Fasching PA, Stroyakovskiy D, Yardley DA, Huang CS, Crown J, Bardia A et al.

Ribociclib plus a nonsteroidal aromatase inhibitor (NSAI) has demonstrated a statistically significant invasive disease-free survival (iDFS) benefit over NSAI alone in patients with hormone receptor-positive/ERBB2 (formerly HER2)-negative early breast cancer. Evaluating the efficacy and safety of...