Gonadorelin Research

Xu G, Li W, Qu J

Müllerian anomalies complicated by extrapelvic endometriosis are uncommon, and herniation of Müllerian remnants into the inguinal canal is exceptionally rare. These complex presentations pose significant diagnostic challenges arising from intricate embryological maldevelopment, necessit...

Yang C, Chen Q, Shen X, Guo H, Lin J, Lu X et al.

Islam T, Yañez-Guerra LA, Semmens DC, Beskeen RT, Egertová M, Elphick MR et al.

The neurohormone kisspeptin regulates reproductive maturation and function in mammals by stimulating hypothalamic production and release of gonadotropin-releasing hormone. However, little is known about kisspeptin-type neuropeptide function in invertebrates and the evolution of kisspeptin signall...

Patel SA, Yadalam AK, van Assen M, Cantu SM, Onnis C, Zheng B et al.

Androgen deprivation therapy (ADT) for men with prostate cancer (PCa) is associated with cardiovascular (CV) morbidity, yet the biological basis remains unclear. Recent studies have yielded conflicting results regarding the CV safety of gonadotropin-releasing hormone (GnRH) agonists vs antagonist...

Gregorio G, Silvia F, Silvia C, Elena R, Antonio R, Jacopo B et al.

Estrogens are fundamental to bone health, exerting life-long effects onbone metabolism. They regulate skeletal growth and maturation during adolescence andmaintain bone remodeling in adulthood. The decline in estrogen levels during perimenopauseand postmenopause leads to bone mass loss. Emerging ...

Sun N, Ding H, Cai L, Chian RC, Deng X, Guan Y et al.

Female fertility preservation (FFP) has become a clinical priority because gonadotoxic therapies for cancer and benign diseases are increasingly common and may cause irreversible ovarian failure. The current clinical practice guideline provides evidence-based recommendations on fertility assessme...

Dodicho AA, Gebeyehu ST, Kidane ZY

In Ethiopia, the reproductive efficiency of dairy cattle utilizing artificial insemination (AI) is low, and implementing estrus and ovulation synchronization protocols could enhance the efficiency. Therefore, this study was designed to evaluate the effect of progesterone (P4) supplementation duri...

Wen X, Li Z, Fang X, Chen A, Zheng X, Lin X et al.

To investigate the incidence of mosaic embryos and identify factors influencing their occurrence.In this retrospective cohort study, 5168 blastocysts from patients who underwent preimplantation genetic testing were analyzed. Mosaic embryos were further analyzed based on mosaic classification, num...

Park JH, Lee JC, Sharma S, Jiang C, Lee H, Park HJ et al.

Human telomerase reverse transcriptase (hTERT) is overexpressed in most human cancers and is an important target for cancer therapy. In this study, HS1002 was synthesized based on the amino acid sequences of gonadotropin-releasing hormone (GnRH) and hTERT. This study aimed to evaluate HS1002's an...

Lima FS, Bruno RGS, Cleale RM, Silvestre F, Wallace R, Short TH et al.

The objective of this study was to evaluate the effect of administering 200 µg versus 100 µg of GnRH as gonadorelin hydrochloride (Factrel; Zoetis, Parsippany, NJ) at the first GnRH injection (G1) of the breeding Ovsynch in a Double-Ovsynch (DO) protocol on pregnancy per artificial inse...

Shim JY, Scatoni A, Laufer MR, Boskey ER

To evaluate the efficacy and tolerability of the gonadotropin-releasing hormone antagonist elagolix for endometriosis-associated pain symptoms in adolescents and young adults (AYA).We performed a retrospective cohort study of AYA with laparoscopically confirmed endometriosis prescribed elagolix b...

Perriere A, Brioude F, Dufourg MN, Rossignol S, Dubern B, Netchine I et al.

Silver-Russell syndrome (SRS) is a rare imprinting disorder characterized by growth retardation, early puberty, and poor pubertal growth, leading to short stature. We aimed to assess the outcome in terms of adult height (AH) and tolerance of combined treatment with recombinant human growth hormon...

Sanagoudar SV, Chandra V, Murdia K, Murdia N, Nigam S, Punhani R et al.

The aim of this study was to find the efficacy of minimal stimulation protocol over antagonist protocol in infertile couples.A total of 10769 patients who visited between January 2018 and January 2022 were included in this retrospective study. To reduce potential bias and baseline heterogeneity b...

Xu CH, Zhang BL, Guan CL, Wang L, Chao S, Li H et al.

Mindfulness-based cognitive therapy (MBCT) demonstrates significant efficacy in improving depressive symptoms and modulating metabolic profiles. However, the specific metabolite biomarkers and metabolic pathways underlying MBCT's therapeutic effects in adolescent depression remain unclear. This s...

Rai SK, Kumar R, Khan MI, Kumar A

Endometriosis is a complex, estrogen-dependent disease with limited effective treatments that often focus on symptom management rather than addressing the underlying pathology. Current therapies, such as progestins and GnRH agonists, have significant side effects (weight gain, mood changes, decre...

Bartlewski J, Oliveira MEF, Bartlewski PM

Sixteen multiparous Santa Inês ewes underwent transrectal ovarian ultrasonography from days 6 to 17 (D6-17; D0 = ovulation). On D6, ewes received a single subcutaneous injection of Firmagon® at a low dose (LD; n = 5; 215 µg/kg body weight [b.w.]) or a high dose (HD; n = 6; 235 &#xb...

Kirsz K, Zięba DA

Orexin-A and orexin-B are hypothalamic neuropeptides that coordinate arousal, metabolic, and reproductive functions through orexin receptor 1 (OX1R) and orexin receptor 2 (OX2R). This review synthesizes evidence from humans, experimental models, and domestic species to examine how orexin signalin...

Shi J, Shen P, Zhang X, Su M, Tang M, Gao Y et al.

Elagolix sodium (ELS), a non-peptide oral gonadotropin-releasing hormone receptor (GnRH) antagonist approved for the treatment of endometriosis-associated pain, displays atypical gelation in aqueous environments along with challenging physical properties such as high hygroscopicity. To address th...

Zhang Y, Zhang X, Deng M, Xu C, Geng Y, Miao J et al.

Fibrosis, angiogenesis and chronic inflammation are the intrinsic characteristics of endometriosis. It is accompanied by significant changes in the cell composition of both ectopic and eutopic endometrial tissues, occurring both before and after treatment with a gonadotropin-releasing hormone ago...

Hong F, Yu H, Zhou F, Tong X

This study aims to compare the outcomes of assisted reproductive treatment in women with low ovarian reserve (LOR), defined as an anti-Müllerian hormone level of ≤1.2 ng/mL, versus normal ovarian reserve (NOR; 1.2 ng/mL < anti-Müllerian hormo...