Glutathione Research

Hsieh MW, Chen HY, Tsai CC

The primary cause of liver damage due to alcohol consumption is long-term intake that disrupts normal metabolism. We focused on evaluating the screening of lactic acid bacteria (LAB) derived from winemaking byproducts to prevent alcoholic liver damage. We employed in vitro cell tests to determine...

Chattopadhayay S, Ganguly D, Sodnawar T, Talukdar P

Controlled transport of ions across the cellular membrane is an essential process. While nature employs stimuli-gated transmembrane proteins to facilitate the appropriate transport of essential ions or molecules across cellular membranes, the endeavor to create a stimuli-controlled synthetic anal...

Huang W, Shi D, Cheng A, Chen G, Liu F, Zhang X et al.

Tricyclazole is widely employed as a pesticide for controlling rice blast. While effective, it simultaneously acts as a stressor on rice plants.Rice seedlings were treated with tricyclazole for 7 days, and the root and shoot samples were collected for analysis. Four biomarkers of oxidative stress...

Pang Y, Yang J, Liu J, Xie Z, Wang J

This review provides an in-depth exploration of the intricate energy metabolism pathways within the brain, with a particular focus on the dynamic interplay between neurons, astrocytes, and microglia. Neurons, with their high energy demands, primarily rely on oxidative phosphorylation and the tric...

Tang L, Li Y, Lv X, Guo J, Zhang Y, Lin Y et al.

Antimicrobial peptides (AMPs) hold promise as anticancer agents but suffer from proteolytic instability, systemic toxicity, and hemolysis. Here, we report a modular redox-responsive polymeric nanocapsule platform for enhanced tumor-targeted AMP delivery. Using melittin (MEL) as a stringent model,...

Jin J, Wang K, Lu C, Yao C, Xie F

The aim of this investigation was to identify the hub genes associated with ferroptosis in keloid. We analyzed the correlation between differentially expressed genes Yin Yang-1 (YY1) and glutathione peroxidase-4 (GPX4) with keloid by quantitative Real‑Time PCR and Western blot. Molecular b...

Joulaeerad N, Hajimehdipoor H, Heidari MH, Kazemi M, Nazarian H, Mofarahe ZS et al.

Freeze-drying is a promising method for the long-term preservation of sperm; however, it often leads to increased oxidative stress. Green tea (Camellia sinensis [L.] Kuntze) contains polyphenols known for their antioxidant properties. This study aimed to evaluate the in vitro effects of green tea...

Das J, Hombalkar SK, Klein AD, Nsasra E, Vasandani M, Petruzzi K et al.

Ferroptosis is a lipid peroxide-dependent form of cell death that occurs in degenerative conditions and may be leveraged for cancer therapy. Although numerous regulators are known to control its cell-autonomous execution, ferroptosis also has a collective property that involves propagation betwee...

Nie R, Zhou H, Chen L, Quan H, Zhang Y, Lin Z et al.

Reprogramming of lipid metabolism is a hallmark of malignant tumors, and targeting key enzymes in lipid metabolism has emerged as a critical strategy to inhibit tumor progression. Sterol regulatory element-binding protein 1 (SREBP1), a master regulator of lipid biosynthesis, drives lipid metaboli...

Fang M, He J, Zhou S, Hong P, Ke L, Wu H et al.

Exposure to microcystins (MCs) can cause severe intestinal damage. This study aimed to assess the efficacy of Pleurotus ostreatus polysaccharide in alleviating intestinal damage induced by microcystin-leucine-arginine (MC-LR) in tadpoles. Over a 30-day period, tadpoles (Pelophylax nigromaculatus)...

Xu H, Xiao J, Li Z, Hu H, Yan F, Qi C et al.

Actinobacillus pleuropneumoniae is a Gram-negative bacterium belonging to the genus Pasteurella. Porcine pleuropneumonia, caused by A. pleuropneumoniae, is a major respiratory disease in pigs and results in significant economic losses to the global swine industry. Sulfur is an essential nutrient ...

Leszczyńska D, Mazurkiewicz M, Sokołowski A, Smolarz K, Włodarska-Kowalczuk M, Legeżyńska J et al.

Pharmaceutical pollutants, such as carbamazepine (CBZ), are increasingly detected in polar marine ecosystems, raising concerns about their bioaccumulation and impact on resident fauna. This study investigated the presence of CBZ and metabolic alterations in two Arctic macrobenthic invertebrates: ...

Cai X, Fan S, Yang P, Zhao L, Jiao Y, Liang J et al.

Qiangji Jianli Decoction (QJJLD), a representative multi-herb formula derived from the Traditional Chinese Medicine (TCM) theory that "the Spleen governs the muscles" (Pi Zhu Ji Rou), embodies the wisdom of classical Chinese medicine. This prescription has been in continuous clinical use in China...

Zhang F, Li X, Yang S, Tang C, Yang J

Injectable hydrogels show great potential in treating breast cancer due to their precise treatment, stimulation response and slow release characteristics. By crosslinking reaction of N-carboxyethyl chitosan (CEC) and oxidized chondroitin sulfate (OXCS), we developed a novel hydrogel (denoted as O...

Wu H, You B, Gao J, Wang Q, Ma J, Cheng B et al.

Oxidative stress critically undermines oocyte quality during in vitro culture. Hydrogen peroxide (H2O2)-induced injury specifically disrupts mitochondrial function and compromises embryonic developmental competence. This study investigated the role of the mitochondrial electron transport chain (E...

Wu G, Wang F, Chen Z, Zheng N, Zhou Q, Xie L et al.

Alzheimer's disease (AD) is a devastating neurodegenerative disorder that currently lacks efficacious therapeutic interventions. It's well documented that ferroptosis is extensively involved in the progression and pathogenesis of AD. Betaine, a critical nutrient for mammal health, is reported to ...

Zhang L, He Y, Zhao A, Han H, Li Y, Li L et al.

Doxorubicin (DOX) is an effective chemotherapy drug, but it has severe hepatotoxicity. Ferroptosis is one of the main mechanisms of DOX-induced liver injury. Beclin1 is a core molecule in regulating autophagy, and it has also been reported to be involved in the regulation of ferroptosis. We aimed...

de Sena JN, Cavalcanti CM, Conde AJH, de Freitas Alves BV, Cesar LFB, da Costa Sousa M et al.

Guanidinoacetic acid (GAA), a precursor of creatine, has emerged as one of the most promising supplements for ruminants in recent years. In its rumen-unprotected form, it is effective in different aspects of animal performance, but there are still no definitive studies on its ability to modulate ...

Misono U, Ishida N, Fumuro A, Katoh H

AMP-activated protein kinase (AMPK) plays a critical role in maintaining cellular energy homeostasis. Activation of AMPK negatively regulates ferroptosis, a form of cell death caused by iron-dependent accumulation of lipid peroxides. In the present study, we unexpectedly found that A769662, widel...

Xiong X, Cheng Y, Li X, Li Y, Xiong Y, Yin S et al.

Rhodiola sachalinensis polysaccharides (RSP), known for their antioxidant qualities, can scavenge superoxide anion radicals and prevent lipid peroxidation. This study aimed to determine the ideal extra concentration to use as a freezing extender additive and to explore the effects of RSP on the q...