GHRP-6 Research

Wang L, Berlanga-Acosta J, Yu H, García-Ojalvo A, Jiang T, Li N et al.

Acute lung injury/acute respiratory distress syndrome is a complex, characterized by acute onset, alveolar damage, and progressive hypoxemia. The subsequent proliferative phase drives to pulmonary fibrosis. Lipopolysaccharide (LPS) and zymosan (ZYM) induced lung injury are commonly used biomodels...

Kihara M, Yamagiwa T, Katayama H, Kaiya H

This study clarified the local mechanism of action and assessed the aquaculture potential of orally administered salmon acylated ghrelin (sAG) on feed intake in common carp (Cyprinus carpio). Experimental diets containing sAG (ranging from 0.001 to 13.04 µg/g) were prepared and fed to...

Rahmania A, Zendehdel M, Hassanpour S

Liver-expressed antimicrobial peptide 2 (LEAP-2), initially identified as an antimicrobial peptide which endocannabinoid and ghrelin action may occur via changes in Leap2 expression. This study aimed to determine effect of ICV injection of LEAP2and its interaction with cannabinoid and ghrelin sys...

Zhao X, Pan K, Li R, Liu M, Li D, Jia P et al.

Renal tubular epithelial cells (TECs), which are highly susceptible to injury during acute kidney injury (AKI), have notable regenerative effects on renal recovery after AKI. AKI-driven metabolic reprogramming of TECs plays a critical role in determining whether kidneys recover functionally or de...

Wei X, Mulumba M, Chemtob S, Ong H, Lubell WD

Isotryptophan (Itr) is the rare 2-indoyl counterpart of the essential amino acid tryptophan. Considering the potential to explore novel side chain χ-space in a residue prone to adopt backbone turn conformers, azaItr has been effectively synthesized and employed in Pictet-Spengler and peptid...

Ostadian C, Hayati N, Zahiri Sorouri Z, Hosseini A

The success rate of in vitro maturation (IVM) for human oocytes is clinically significant, prompting a focus on optimizing IVM media culture. While various factors have been incorporated to improve outcomes, the role of Ghrelin hormone, despite its multifunctional nature, remains poorly investiga...

Rodríguez-Viera L, Caderno A, Martinez R, Martinez-Rodríguez G, Oliva M, Perera E et al.

The aquaculture industry has experienced considerable growth in recent decades, stimulating research into sustainable and functional feed formulations, mainly related to using high-quality, safe, and environmentally friendly feed ingredients. The employment of immunomodulatory additives is a prom...

Olivier N, Harvey BH, Gobec S, Shahid M, Košak U, Žakelj S et al.

Major depressive disorder (MDD) is often treatment resistant, particularly in addressing anhedonia and cognitive deficits. Novel pharmacological strategies are needed. While butyrylcholinesterase, ghrelin, and dopamine (DA) have been well studied in the context of stress and MDD, their interactio...

Zhang X, Cai Y, Chen M, Chen L, Mao Y, He R et al.

Guanxin II, proposed by Chen Keji (National master of traditional Chinese medicine), possesses neuroprotective effect. Interestingly, its simplified prescription Danshen-Chuanxiong-Honghua (DCH) can also clinically ameliorate cerebral impairment and improve spatial cognitive deficits, similar to ...

Zhu J, Zhou T, Chen G, Gao H, Chen X, Tuohetali A et al.

Cystic echinococcosis (CE) is a parasitic disease caused by the larval stage of Echinococcus granulosus, and the immunosuppressive microenvironment exacerbates disease progression. Ghrelin, a peptide hormone, plays a role in modulating immune inflammation and may influence the progression of E. g...

Beuker C, Schreiner U, Strecker JK, Altach E, Rätzel V, Schmidt-Pogoda A et al.

The neuroprotective and proangiogenic potential of ghrelin in acute ischemic stroke has been demonstrated in experimental studies. However, the transferability of these results is limited as ghrelin was administered either before or very early after stroke onset and follow-up was limited to the f...

Castro J, Shaikh I, Silo S, Hum C, Carrier M, DiFruscia R et al.

CIGB-500 is a product whose active pharmaceutical ingredient is GHRP-6, (Growth Hormone Releasing Peptide-6), a synthetic peptide that allows the rescue of cardiac mass affected during Acute Myocardial Infarction. The objective of the study was to determine the toxicity profile of CIGB-500 in dog...

Kaiya H, Nobata S, Takei Y

In general, ghrelin is known as one of the orexigenic (increasing appetite or food intake) hormones in mammals. However, it has also been shown that ghrelin inhibits water intake, which appears to be inconsistent with its role in the feeding response. In this study, the effect of ghrelin on water...

Ayman J, Buzás A, Dochnal R, Palotai M, Jászberényi M, Bagosi Z et al.

Background/Objectives: Ghrelin and growth hormone-releasing peptide 6 (GHRP-6) are peptides which can stimulate GH release, acting through the same receptor. Ghrelin and its receptor have been involved in reward sensation and addiction induced by natural and artificial drugs, including nicotine. ...

Poelman R, Le May MV, Schéle E, Stoltenborg I, Dickson SL

Ghrelin, the endogenous ligand of the growth hormone secretagogue receptor (GHSR), promotes food intake and other feeding behaviors, and stimulates growth hormone (GH) release from the pituitary. Growth hormone secretagogues (GHS), such as GHRP-6 and MK-0677, are synthetic GHSR ligands that activ...

Elimam H, Gauvin J, Huynh DN, Ménard L, Al-Hawat ML, Harb D et al.

Reperfusion of ischemic skeletal muscle triggers oxidative stress and an immediate inflammatory reaction, leading to damage of distant organs such as the lungs. The inflammatory process implicates numerous mediators, including cytokines, chemokines, and arachidonic acid metabolites. In the orches...

Matsui K, Ida T, Oishi K, Kojima M, Sato T

Daily torpor is an active hypothermic phenomenon that is observed in some mammals and birds during fasting. A decrease in blood pressure has also been observed in torpor; however, there remains a lack of knowledge of the underlying mechanism. We have previously reported that ghrelin, an orexigeni...

Zhu J, Zhao H, Aierken A, Zhou T, Menggen M, Gao H et al.

Cystic Echinococcosis (CE) is a zoonotic disease causing fibrosis and necrosis of diseased livers caused by infection with Echinococcus granulosus (E.g). There is evidence that E.g is susceptible to immune escape and tolerance when host expression of immunoinflammation and fibrosis is suppressed,...

Goudsward HJ, Ruiz-Velasco V, Stella SL, Herold PB, Holmes GM

The orexigenic gut peptide ghrelin is an endogenous ligand for the growth hormone secretagogue receptor type 1a (GHSR1a). Systemic ghrelin administration has previously been shown to increase gastric motility and emptying. While these effects are known to be mediated by the vagus nerve, the cellu...

Yakabi K, Yamaguchi N, Takayama K, Hosomi E, Hori Y, Ro S et al.

Rikkunshito (RKT), a traditional Japanese medicine, can relieve epigastric discomfort and anorexia in patients with functional dyspepsia. RKT enhances the orexigenic hormone, ghrelin. Ghrelin regulates food motivation by stimulating the appetite control center in the hypothalamus and the brain me...