Ghrelin Research

Alharbi NS, Hamdy NA, Aboubakr EM, Alharbi M, Ali MA, Alharbi G et al.

Olanzapine (OLZ), haloperidol (HALP), and their combination, are widely used antipsychotics; the majority of studies focuses on their therapeutic efficacy, leaving significant gaps in understanding their systemic impacts. Hence, the present study was conducted to investigate their systemic, metab...

Lascarrou JB, Benghanem S

Nugraha HD, Jamaludin SNF, Matsumoto R, Ohkawa S, Tomaru H, Juanda I et al.

Ditmer M, Wojtera A, Gabryelska A, Turkiewicz S, Białasiewicz P, Strzelecki D et al.

Deprivation of sleep (DS) is widespread in modern societies and is associated with cardiometabolic, cognitive, and psychiatric disturbances. Acute DS has also been reported to produce short-lived improvements in mood in some individuals with depression, suggesting the involvement of specific biol...

Grabia-Lis M, Zielińska Z, Gorodkiewicz E, Socha K, Bossowski AT, Markiewicz-Żukowska R et al.

Zizzari P, Ramírez-Penas O, Pons V, Oujezdska M, Sammarcelli AL, Saint-Yves T et al.

Severe calorie restriction in mouse models has highlighted the crucial role of the ghrelin system in maintaining glycemia and promoting survival. We hypothesized that if ghrelin acts as a survival signal, enhancing the responsivity of the GH secretagogue receptor (GHSR) should favor GHSR protecti...

Szymańczyk S, Osiak-Wicha C, Kras K, Kapica M, Puzio I, Antushevich H et al.

Apelin is a postnatal peptide implicated in gastrointestinal maturation, yet its combined effects on mucosa, enteric plexuses, and gut-derived appetite signals are not well defined. We investigated the impact of chronic intragastric apelin-13 on the stomach and small intestine of unweaned rats. T...

Boyd J, Newman M, Connery H, Warner K, Riexinger C, Chaves M et al.

Chlorine gas (Cl2) is a highly toxic chemical associated with both localized lung injury and systemic health effects. While pulmonary damage has been well characterized, the systemic inflammatory and metabolic responses remain poorly understood. We aimed to define the temporal and multi-organ res...

Caderno A, Tang P, de Las Heras V, Gharbi N, Alarcón-López FJ, Mancera JM et al.

Appetite regulation in fish relies on complex neuroendocrine pathways within the brain-gut axis, with ghrelin (Ghrl) and cholecystokinin (Cck) as central players. However, their spatial distribution along the gastrointestinal tract (GIT) and responses to feeding status remain poorly understood in...

Bæch-Laursen C, Ucin JV, Galsgaard KD, Llana J, Kissow H, Rehfeld JF et al.

Physical activity helps maintain a healthy stable body weight. One mechanism underlying this beneficial effect could be the improved coupling between energy intake and expenditure, since hunger and satiety are better regulated in active individuals. Whether this enhancement of appetite control by...

Lacombe V, Vinatier E, Aurrière J, Blanchet O, Annweiler C, Lavigne C et al.

Diagnosis of pernicious anemia remains challenging in patients with vitamin B12 deficiency and isolated anti-parietal cell antibodies (APCA) because of their limited specificity. Prior biomarker studies mostly excluded patients receiving proton pump inhibitors (PPIs). We aimed to assess the diagn...

Goulet V, Léveillé D, Li J, Fisette A

Energy metabolism and fertility are intricately linked across the female lifespan, from puberty through pregnancy, lactation, and menopause, ensuring that nutrition aligns with reproductive demands. We review here the nature of the synergistic crosstalk between sex hormones (notably estradiol) an...

Doval-Caballero JLE, Ferreira-Hermosillo A, Eugenio-Ponce GD, García-Sáenz MR, Ibarra-Salce R, Tenorio-Rojo AP et al.

The perception of taste is a complex physiological process that extends far beyond the simple detection of flavor molecules, serving as a critical interface between nutrient sensing, metabolic regulation, and feeding behavior. Emerging evidence reveals that this process is profoundly modulated by...

Minnetti M, Poggiogalle E, Frigerio F, Piciocchi C, Pierantozzi G, Di Vincenzo O et al.

Sarcopenic obesity (SO) is a multifactorial condition characterized by the coexistence of excess adiposity and reduced skeletal muscle mass and function. Its development reflects a complex interaction of metabolic, inflammatory, and endocrine mechanisms that disrupt the balance between anabolic a...

Cavalcanti Bezerra Gouveia HJ, Dos Santos-Júnior OH, Frasnelli J, Fisette A, Dos Santos Júnior JP, da Silva Araújo MA et al.

Ghrelin plays a crucial role in metabolism and gastrointestinal function. In the central nervous system, ghrelin modulates both hedonic and homeostatic control of eating behavior. Ghrelin promotes neuron survival by reducing apoptosis, inflammation, and oxidative stress, making it a potential the...

Pérez RE, Ordaz G, López M, Ortiz R

The gestation-lactation transition involves high metabolic demand, and backfat thickness (BFT) better reflects adiposity and endocrine function than body weight (BW). This study evaluated the relationships between body condition indicators (BFT and BW), daily feed intake (DFI), and metabolic and ...

Zhou X, Liu Q, Zhang F, Hou M, Wang P, Huang J et al.

To investigate the variations of serum ghrelin levels in children with left-to-right shunt CHD, and analyse the correlation with the geometric structure of the heart. It may provide some clinical guidance for evaluating the early changes of cardiac structure and function in CHD children.A total o...

Pinto RR, Ruivo R, Stiller J, Oliveira D, Castro LFC, da Fonseca RR et al.

Exploring the evolution of gene networks associated with metabolic/energetic homeostasis can yield key insights into the adaptive landscapes governing the physiology of extant lineages. Here, we investigate a key hormonal module of energy metabolism in reptiles. Ghrelin (GHRL), also known as the ...

Khaira F, Sulastri D

Ghrelin is a peptide hormone that plays a central role in short-term appetite regulation and energy balance. Its secretion is not only influenced by nutritional status but also shaped by circadian rhythms and habitual eating patterns. Ghrelin levels typically rise during fasting and decrease afte...

Koga D, Kusumi S, Sato T

Ghrelin-producing cells (ghrelin cells) in rat fundic glands were analyzed three-dimensionally by combining serial section scanning electron microscopy with immunogold labeling to elucidate their ultrastructural characteristics. This approach enabled unambiguous identification of ghrelin cells an...