GHK Research

Manoj KM, Jaeken L, Gideon DA, Tamagawa H, Kavdia M

The classical membrane pump theory (CMPT) is an acclaimed hypothesis in cellular electrophysiology, which solicits the functioning of high-affinity/selective electrogenic and size-based pumping/channeling of cations by membrane-embedded proteins. Herein, we analyze the structure-function correlat...

Duong AL, Kaida K, Goto K, Kojima I, Delalande B, Tamagawa H et al.

The Goldman-Hodgkin-Katz (GHK) equation provides a quantitative description of the membrane potential, a quantity commonly ascribed to passive and active ion movements through channels and pumps in the plasma membrane. Consequently, the membrane potential is frequently viewed as a hallmark of liv...

Jeong SA, Talukder A, Jeong YH, Son MG, Kim GH, Lim BO et al.

Chamaecyparis obtusa (Hinoki cypress) has been extensively studied for its leaves and bark, which are known to contain high levels of polyphenols and flavonoids with potent bioactivities. In this study, the phytochemical transformation and changes in bioactivity of C. obtusa leaves were investiga...

Arciola CR, Panichi V, Bua G, Costantini S, Bottau G, Ravaioli S et al.

To address the challenges in wound healing, clinical management increasingly demands targeted, adaptive, responsive, and patient-centered strategies. This is especially true for wounds characterized by delayed healing and a high risk of infection. Advances in regenerative medicine and biomaterial...

Alferova ME, Bobyntsev II, Vorvul AO, Tenkova AN

The anxiolytic effects of Gly-His-Lys-Pro-Gly-Pro peptide (GHK-PGP) and its proline-containing analogs were studied in a test with punished behavior. Peptides Gly-His-Lys (GHK), Pro-Gly-Pro (PGP), GHK-PGP, Gly-His-Lys-Gly-Pro (GHK-GP), and Gly-His-Lys-Pro (GHK-P) were used. Anxiolytic activity wa...

Rahman OF, Lee SJ, Seeds WA

Therapeutic peptides are emerging as promising adjuncts in the management of orthopaedic injuries, grounded in their ability to modulate molecular signaling networks central to cellular medicine. By acting on key pathways such as PI3K/Akt, mTOR, MAPK, TGF-β, and AMPK, peptides exert influen...

Mayfield CK, Bolia IK, Feingold CL, Lin EH, Liu JN, Rick Hatch GF et al.

Therapeutic peptides are short-chain amino acids that regulate cellular functions and facilitate biochemical processes. In recent years, there has been significant growth in the global market for therapeutic peptides and thus its popularity among patients. Given the increase in the development of...

Naletova I, Rizzarelli E

Two endogenous peptides, β-alanyl-L-histidine, named carnosine (Car), and glycyl-L-histidyl-L-lysine (GHK), derived from the matricellular protein Secreted Protein Acidic and Rich in Cysteine (SPARC), share many beneficial functions. The hydrolytic enzyme carnosinase for Car and the low sta...

Oh AS, Humphries SM, Chung A, Weigt SS, Brown M, Kim GHJ et al.

Computed tomography (CT) is routinely used in diagnosing and managing patients with chronic lung diseases such as chronic obstructive pulmonary disease (COPD) and fibrosing interstitial lung disease (ILD). Visual assessment of disease morphology/phenotype and extent correlates with lung function ...

Ye H, Zhen Y, Chen S, Lin Y, Xu X, Yu Y et al.

Nicotinamide mononucleotide (NMN), a potent nicotinamide adenine dinucleotide (NAD+) precursor, has demonstrated significant potential in mitigating mitochondrial oxidative stress, alleviating degenerative diseases, and reducing reactive oxygen species (ROS) generation. However, its topical appli...

Wang R, Xu Y, Saiding Q, Ling S, Yu J, Zhuang Y et al.

Copper-dependent proteins (such as lysyl oxidase, LOX) require copper acquisition within the Golgi apparatus to achieve enzymatic activation, and insufficient activation of these proteins is a key factor limiting fascia regeneration. To address this issue, this study, for the first time, proposes...

Yu Z, Fontes Marques I, Kebede Merid S, Burrows K, Soares AG, Pyko A et al.

Road traffic noise exposure has been associated with multiple adverse outcomes in epidemiological studies. However, the underlying biological mechanisms remain unclear. The aim of this study was to investigate the association between road traffic noise exposure and cord blood and child blood DNA ...

Lu T, Hamidi H, Socinski MA, Reck M, Cappuzzo F, Barlesi F et al.

The phase 3 IMpower150 trial in treatment-naïve patients with metastatic non-small-cell lung cancer (NSCLC) demonstrates significantly longer progression-free (PFS) and overall survival (OS) with first-line atezolizumab (anti-PD-L1)-bevacizumab (anti-VEGF)-carboplatin-paclitaxel (ABCP) than ...

Nathan MD, Spagnolo PA, Grant LK, Rahman SA, Gonsalvez I, Harder J et al.

The menopausal transition (MT) represents a period of increased risk for depressive symptoms. Emergence of these symptoms may reflect dysregulations in affect caused by fundamental MT characteristics, particularly sleep disturbance, estradiol decline, and vasomotor symptoms (VMS). Using an experi...

Chia SM, Krstic S, Lin F, Dennis S, Southcombe F

This study aims to explore adolescents' perspectives on their experiences with Growing Healthy Kids (GHK), a multidisciplinary weight management service, evaluating their overall satisfaction and identifying areas for improvement in service delivery, acceptability, and effectiveness.A qualitative...

G M, C S, G HK, I N

Seizure identification using EEG is crucial but traditionally relies on specialists, making it time-consuming and variable. Existing systems suffer from limited feature extraction and inefficient optimization. To overcome this, Optimized Dense Back-Projection Joint Attention Network for Automatic...

Burkart K, Wozniak S, Anenberg S, Pereda A, Gilbertson N, Ashbaugh C et al.

Asthma, a chronic lung condition characterised by inflammation and airway constriction, has been associated with nitrogen dioxide (NO2) exposure, an association that particularly impacts children. Our study rigorously assessed this relationship and estimated the global burden of childhood asthma ...

Adnan SB, Maarof M, Fauzi MB, Fadilah NIM

Wound healing is a complex and dynamic process that requires the coordination of cellular, molecular, and physiological events to restore tissue integrity. Despite notable advances in treatment strategies, optimizing healing outcomes, particularly in chronic wounds, remains a major challenge. Eme...

Angelakopoulos N, Merdietio Boedi R, Franco A, Polukhin N, Kumagai A, Galic I et al.

In forensic contexts, age assessments constitute matters of substantial legal consequence, particularly in proceedings involving children and young adolescents. Dental age estimation (DAE) techniques are widely used for this purpose, especially in cases involving undocumented minors. This st...

George M, Chipps BE, Beuther DA, McCann W, Reibman J, Wise RA et al.

SummaryWhat is this summary about?• The Asthma Impairment and Risk Questionnaire (AIRQ®) has been designed and tested to measure patients' levels of asthma control in a healthcare setting.• Unlike other available questionnaires that only assess asthma symptoms tha...