Galanin Research

Zeng Y, Xu D, Li X, Jiang Q, Liang S

With the intensification of population aging, age-related cognitive decline has emerged as a significant global health issue. Neuroinflammation, neuronal apoptosis, and pyroptosis have been identified as key factors in neuronal loss, a hallmark of age-related neurodegenerative conditions. Dihydro...

Samad N, Manzoor N, Saleem S, Khaliq S, Ejaz U, Arshad M et al.

This research focuses on the protective impacts of gallic acid (GAL) on OMP-instigated anxiety. In this experiment, 48 male Sprague-Dawley rats were grouped into 6 (n = 8): (I) VEH + VEH (1 mL kg-1), (II) VEH + GAL [low dose; (50 mg kg-1)] (III) VEH + GAL [high dose; (100 mg kg-1)] (IV) VEH + OMP...

Xu P, Fan H, Yu M, Fei Y

To investigate the efficacy and safety of intravenous infusion of lidocaine combined with pulsed radiofrequency in the prevention of postherpetic neuralgia.A total of 110 patients with herpes zoster who met the criteria were finally included by calculating the sample size and randomly divided int...

Pujol N, Gal J, Gautier M, Rizzi Y, Courtault-Deslandes F, Schiappa R et al.

In the case of a second ipsilateral breast cancer event (2nd iBCE) after breast-conserving treatment (BCT), tumor histology and topography are used to distinguish between true recurrence (TR) and new primary (NP). This study aimed to address the lack of data to accurately define TR and NP.Patient...

Heriniaina RM, Chen X, Wu Y, Liao W, Fei H, Wang P et al.

Pancreatic cancer, specifically pancreatic ductal adenocarcinoma (PDAC), ranks among the most prevalent malignancies and is a leading cause of cancer-related mortality worldwide. Therefore, there is an urgent need to identify novel anti-pancreatic cancer agents. This study reports a newly identif...

Galili U, Zhao Y

Oncolytic-viruses (OV) decrease tumor-mass but are less successful in eliciting long-term protective immune-response against tumor-antigens (TAs), due to poor uptake of tumor-cells by antigen-presenting-cells (APCs). It is postulated that this anti-tumor immune-response may greatly increase with ...

Mazurek MH, Maguire AJ, Sixkiller JD, West TR, Perez NA, Wetzel EA et al.

The identification of eloquent structures in the parietal lobe during awake craniotomy remains challenging, particularly for higher-order functions such as reading, calculation, and sensorimotor integration essential for writing and typing. Our study introduces a novel task as part of intraoperat...

Trlin HJF, Bennie RZ, Ogilvie OJ, Oh JK, Jin A, America AHP et al.

Cellular agriculture combines cell culture and tissue engineering techniques to produce animal-derived food products. While cell culture is routinely reported in the medical literature to affect protein expression in primary mammalian cells, the impact of these changes has yet to be established i...

Shi M, Jia Z, Yang X, Qi W, Sun X, Li Y et al.

Ovarian aging is an inevitable age-associated biological phenomenon.Enhancing clinical pregnancy outcomes in women with advanced maternal age (AMA) has emerged as a critical research priority in reproductive medicine. The current study seeks to unravel the mechanism governing mitochondrial energy...

Biswas P, Aram L, Livni N, Kamyshinsky R, Elad N, Leskes M et al.

Silica-based materials are of immense functionality as their production is versatile and can accommodate a wide range of properties. Nevertheless, no synthetic system can reproduce the ability of organisms to precipitate dense silica under ambient conditions and from dilute soluble precursors, le...

Sami N, Parikh MA, Mihatov N, Frishman WH, Peterson SJ

Biomaterials derived from nonhuman mammals are increasingly used in cardiovascular interventions, yet xenoimmune responses to these materials can complicate these procedures. Xenoimmunity describes the immune response mounted against foreign cells, tissues, or organs from different species. Alpha...

Baba T, Godbehere G, Takeda U, Chen Z, Reddy D, Ryumin P et al.

In our previous publication [Anal. Chem. 2023, 95, 7458-7467], we demonstrated the use of electron capture dissociation for Sa linkage analysis in N-glycans; however, its application was challenging because its diagnostic capabilities depended on the size of the glycans and peptide backbones. In ...

Pham NTH, Paré A, Létourneau M, Fortier M, Chatenet D, St-Pierre Y et al.

Allosteric modulation enables precise control of protein activity but remains difficult to harness for selective inhibitor design. Traditional high-throughput screening for allosteric modulators is still costly and time-consuming, underscoring the need for predictive computational approaches. Her...

Soulié M, Sánchez-Bayuela T, Lima-Posada I, Stephan Y, Nicol L, Lamiral Z et al.

Patients with chronic kidney disease (CKD) are at high risk of cardiovascular complications. We have shown that Ngal (neutrophil gelatinase-associated lipocalin)/lcn2 is involved in aldosterone-induced cardiac remodeling and inflammation. Here, we investigated the role of Ngal in the progression ...

Xu M, Xu M, Zhu H, Qian K, Shao H, Huang J et al.

Upon infection, viruses reprogram the host metabolic system to hijack metabolic resources for proliferation. Avian leukosis virus subgroup J (ALV-J), an avian oncogenic virus, poses significant challenges to the poultry industry. ALV-J infection upgrades monosaccharide N-acetylgalactosamine (GalN...

Gupta S, Gal ZT, Touray J, Luiselli GA, Ceesay A, Manneh EK et al.

Access to specialty surgical care is growing in many low-income countries, but it remains unclear how hospital workforces can leverage technology to manage large numbers of increasingly complex patients. Large language models (LLMs) may be helpful for this type of clinical decision support, but t...

Bajaj S, Mahesh R

Alzheimer's disease (AD) is the most prevalent form of dementia, accounting for more than two-thirds of cases in older adults. AD is associated with neuropsychiatric symptoms such as depression, anxiety, and sleep disturbances. The coexistence of AD with depression, in particular, poses serious c...

Ji Y, Liu RX, He PY, Zhou YM, Li YC, Guo J et al.

Diabetic kidney disease (DKD) continues to pose a substantial public health challenge, in which cellular senescence is recognized as a pivotal driver of disease progression. While formononetin (FN) has been documented to exhibit anti-senescence properties, its potential as a therapeutic agent for...

Zhu Y, Xu W, Wan C, Deng B, Xie Y, Yang B et al.

Acute kidney injury (AKI) is a severe clinical syndrome with high morbidity and mortality, yet its pathogenesis remains incompletely understood, and effective therapeutic strategies are still lacking. In this study, we observed significant upregulation of N-acetyltransferase 10 (NAT10) in the tub...

Orenha RP, Molina EF, Alves FB, Fico BA, Albuquerque M, Parreira RLT et al.

Polymer-based materials have emerged as promising platforms for controlled nutrient delivery in agriculture, offering enhanced efficiency and sustainability. In this study, we performed molecular dynamics simulations to investigate the self-assembly mechanism of Medipacs epoxy polymer (MEP113) ve...