Follistatin Research

Liu C, Zhang A, Li Z

Follistatin is a secreted protein whose main role is antagonizing the activity of transforming growth factor β (TGF-β) superfamily members. Our study aimed to evaluate the serum follistatin levels and establish their relationship with vascular calcification (VC) in haemodialysis (HD) ...

Ye L, Peng L, Tian J, Ma H

Puerarin is a flavonoid bioactive component extracted from the Chinese herb radix puerariae, which has been reported to have anti-inflammatory and neuroprotective effects and is a potential drug for the treatment of neuroinflammatory diseases. There is increasing evidence that the gut-liver-brain...

Käch D, Loera-Sánchez M, Reidy B, Studer B, Kölliker R

Permanent grasslands are predominantly composed of allogamous plant species that exhibit high levels of plant genetic diversity (PGD) within their populations. Grasslands with high PGD are more resilient to environmental stress and constitute valuable reservoirs of genetic resources for plant bre...

Darvishzadeh R, Alipour H, Türkoğlu A, Haliloğlu K, Fatanatvash S

Sunflower (Helianthus annuus L.) is a valuable oilseed crop with significant economic importance. Enhancing breeding strategies in this species heavily relies on genetic diversity and molecular tools. Among these tools, SNP-based genotyping has proven to be an effective method for exploring genom...

Lim L, Von KY, Ab Majid AH

Macrotermes carbonarius is a fungus-growing termite widely distributed in Southeast Asia and is ecologically important in both natural and urban environments. In Malaysia, this species may act as a secondary pests following the suppression of primary termite infestations, making an understanding ...

Yang J, Yuan G, Shuang R, Chen C, Zhang J, Wu T et al.

Zhi-Zi-Hou-Po decoction, a classic herbal formula in traditional Chinese medicine, has long been used clinically for the treatment of depression. However, the precise molecular mechanisms underlying its antidepressant effects remain to be fully elucidated.This study aimed to characterize the chem...

Li Q, Ling H, Li J, Li J, Duan W, Guo L et al.

Sepsis-induced immunosuppression, characterized by dendritic cell (DC) depletion, correlates with poor outcomes. The glycoprotein FSTL1 is elevated in sepsis, but its contribution to DC pyroptosis and subsequent immune dysfunction remains unknown.We utilized in vitro models with splenic DCs and m...

Wang Y, Liu Y, Feng Y, Bo L, Xiao Z, Wang H et al.

We aimed to assess the safety of continuous uterus-preserving treatment among patients with endometrial cancer (EC) and atypical endometrial hyperplasia (AEH) who gave birth after progestin-based fertility-sparing treatment (FST).From January 2005 to June 2020, we conducted a retrospective c...

Karcioglu Batur L, Yavas C, Kilic A, Dogan T, Yilmaz M, Pektas A et al.

Chronic stress is known to impair emotional regulation and adaptive behavioral responses through neuroinflammatory activation, oxidative imbalance, and dysregulation of neuroplasticity-related genes. Kiperin Mind Focus, a nootropic nutraceutical containing L-theanine, citicoline, phosphatidylseri...

Parveen S, Shafi Z, Shahid M, Iqbal MZ, Naznine F, Ansari MI et al.

Soil microbial diversity plays a pivotal role in sustainable agriculture by regulating nutrient cycling, organic matter turnover, and natural suppression of phytopathogens, thereby supporting crop productivity and ecosystem resilience. However, intensive agricultural practices and environmental s...

Jin J, Wen C, Li J, Mai C, Yuan J, Wang P et al.

The harsh environments of high-altitude habitats present formidable challenges for animal survival and reproduction. The adaptation of plateau endotherms to hypoxic and cold stresses has been studied for more than a century. However, the responses and contributions of the symbiotic microbiota to ...

Wang S, Liu Y, Chen S, Yao L, Zeng C, Xia Q et al.

Neuropathic pain (NP) is marked by ongoing nociceptive signals and accompanied by symptoms resembling depression, which complicates treatment strategies. Melatonin (MT), a hormone known for its neuroprotective properties, has garnered attention for its potential in NP treatment, but its precise m...

Li J, Li Y, Zhang Y, Li H, Liu C, Du Y et al.

Postpartum depression is a severe mental disorder affecting approximately 10% to 20% of women after childbirth, yet the physiological mechanism behind this is poorly understood. The NLRP3 inflammasome is pivotal in neuroinflammatory and neural disorders. It undergoes a dual modulation by mitochon...

Alothaid H, Alghnnam F, Al-Qahtani AA, Al Marzan A, Abu Alola M, Bohol MFF et al.

Malaria remains a persistent health challenge in southern Saudi Arabia, particularly along the border with Yemen. Understanding the genetic diversity and population structure of Plasmodium falciparum antigens is essential for tracking transmission dynamics and informing vaccine design. This study...

Peng W, Wang Y, Zhang Y, Gao L, Wu L, Wang S et al.

In the expansive African region, goats display a diverse array of breeds that have evolved over time to adapt to varying local climates and environments. This study involved the analysis of 1591 samples, including 63 domestic breeds and 164 individuals from wild related species, focusing on genet...

Sertse D, Bekele WA, McCartney CA

Wheat is one of the world's most important crops, cultivated across diverse ecogeographic zones on more than ~245 million hectares annually. Classified by vernalization requirement into spring, facultative, or winter types, the latter typically achieves higher yields due to its extended growing s...

Razi O, Shafei A, Abdi M, Saeidi B, Farzanegi P, Zamani N et al.

Objective: This study evaluated the effects of a 12-week High-Intensity Functional Training (HIFT) program combined with thylakoid supplementation on plasma adipo-myokine levels (Decorin, Myostatin, Follistatin, Activin A, and TGF-β1) in men with obesity. Secondary outcomes included anthrop...

Ulutaş F, Kaya K, Yiğit N, Çobankara V

Background/Objectives: Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) represents one of the major contributors to morbidity and mortality in Rheumatoid arthritis (RA), yet its underlying molecular mechanisms remain incompletely defined. Activin A, a member of the transforming ...

Zeng W, Ye Z, Liu X, Lin H, Wu J

Coptis chinensis var. brevisepala W. T. Wang & P. G. Xiao is an endemic and endangered medicinal plant in China whose wild populations are rapidly declining under the combined pressures of overharvesting, climate change, and habitat fragmentation. Using genotyping-by-sequencing, we analyzed 8...

Zhou L, Zhu L, Ma F, Gu M, Na R, Zhang W et al.

Genomic selection often faces challenges of insufficient prediction accuracy in cross-population applications, primarily due to differences in linkage disequilibrium patterns between populations. This study proposes an Fst-based strategy to enhance prediction performance by constructing a cross-p...