Eptifibatide Research

Takada YK, Wan YY, Takada Y

Galectin-3 (Gal3) is one of the most pro-inflammatory proteins and a biomarker of inflammatory diseases and cancer. Previous studies showed that Gal3 binds to αv and β1 integrins but it is unclear how Gal3 binds to integrins. Here, we show that Gal3 bound to soluble αvβ3 a...

Wang B, Chen X, Niu D, Wang Y, Zhang Y, Li J et al.

Gingival bleeding (GB) is often the initial symptom of gingivitis and periodontitis, and also an oral manifestation of certain systemic diseases. Its early prevention is of great significance for both oral and systemic health. This study aimed to identify risk drugs and their clinical characteris...

Parsova KE, Kahraman E, Durak F, Isgandarov K, Velibey Y

Background and Objectives: Inflammation contributes to plaque rupture and thrombosis in ST-elevation myocardial infarction (STEMI). The Aggregate Index of Systemic Inflammation (AISI) is a novel biomarker that reflects innate immune and thrombotic activation. Due to the connection between inflamm...

Mokin M, Jovin TG, Sheth SA, Nguyen TN, Asif KS, Hassan AE et al.

Recent randomized clinical trials of endovascular therapy in patients with large infarct provided new evidence in support of endovascular interventions in patients with acute ischemic stroke. The Society of Vascular and Interventional Neurology Guidelines and Practice Standards committee aims to ...

Ali H, Shehzad R, Ahmed U, Abualown Y, Perveen W, Gulzar J et al.

Acute ischemic stroke (AIS) is one of the most common cerebrovascular diseases, posing a substantial burden on public health systems and individuals. Tirofiban and eptifibatide are used alongside intravenous thrombolysis (IVT) in patients with AIS, as they are believed to improve clinical outcome...

Gadelmawla AF, Emara A, El-Farargy SH, Diaa A, Abdallfatah A, Albukhari AF et al.

Early platelet-mediated re-occlusion and microvascular "no-reflow" can blunt the benefits of intravenous thrombolysis (IVT) in acute ischemic stroke (AIS). Tirofiban, a short-acting GP IIb/IIIa inhibitor, may stabilize post-lysis reperfusion. Our analysis assessed the efficacy and safety of adjun...

Cernik D, Neumann J, Neradova J, Hlinena V, Viglas P, Cihlar D et al.

The success of the technical implementation of mechanical thrombectomy (MT) depends on many factors. Considering the experience of the interventional radiologist and the anatomical vascular differences of individual patients, it has technical limits. In our group, we focused on verifying the effe...

Scavone M, Fioretti A, Molinaro M, Ghali C, Martinelli C, Mencarini T et al.

Endothelial and platelet dysfunction are central to vascular disease development. We established a simplified, reproducible 96-well plate model to assess platelet adhesion to endothelial cells under conditions mimicking in vitro endothelial dysfunction and platelet hyperactivation. Human aortic e...

Mosallami Aghili SM, Santori D, Denice C, Dashti R, Geralemou S, Andraous W et al.

Pretreatment with dual antiplatelet agents (DAPT) has been standard practice for patients undergoing aneurysm treatment with flow diversion (FD). Rates of periprocedural diffusion lesions observed after FD procedures remain high (>50%). We assessed the feasibility of intraprocedural eptifibati...

Gothelf I, Epstein M, Shiloh A, Lebowitz Z, Zlotnik Y, Sacho RH et al.

Objective: Stent-assisted treatments for intracranial aneurysms, including stent-assisted coiling (SAC) and flow diversion (FD), are associated with an increased thrombotic risk despite dual antiplatelet therapy (DAPT). Recently, intravenous prophylactic protocols incorporating glycoprotein IIb/I...

Modi B, Cain R, Stork R, Tarpey G, Colucciello A, Olivier D et al.

Background/Objectives: Patients that undergo percutaneous coronary intervention (PCI) require effective antiplatelet therapies to minimize the risk of thrombotic cardiovascular events. Oral P2Y12 inhibitors are often utilized, however co-administered opioids may lead to gastric absorption issues ...

Tashbook SE, Kaminski TW, St Croix CM, Watkins SC, Sundd P, Brzoska T et al.

In situ pulmonary arterial thrombosis (iPAT), occurring without concurrent deep vein thrombosis, is a life-threatening complication associated with various pathological conditions. The etiological mechanisms underlying iPAT remain poorly understood. Several studies suggest that circulating tissue...

Durrani I, Imtiaz I, Anjum AF

Kalhor P, Nowrouzi P, Ghahari P, Mehrani M

Coronary artery disease (CAD) is a leading cause of death worldwide. Among acute coronary syndromes, non-ST-elevation myocardial infarction (NSTEMI) poses a higher long-term risk than ST-elevation myocardial infarction (STEMI). Eptifibatide, a glycoprotein IIb/IIIa inhibitor, is used during percu...

Chen J, Liu S, Shen Y, Xiong H, Chen C, Xiao B et al.

Antiplatelet and anticoagulation are the cornerstones for arterial and venous thrombosis, respectively; however, hemorrhage remains a significant clinical challenge. Platelets are crucial for arterial thrombosis and contribute to venous thrombosis. Integrin β3 mediates outside-in signaling,...

Roy A, Elm J, Ingles JR, Sabagha N, Huang JF, Bentho O et al.

IV thrombolysis only (IVT-O) is the primary reperfusion therapy for most stroke patients. At least 50% of IVT-O patients remain disabled. We assessed 2 therapies added to IVT-O aimed at increasing clot lysis or preventing arterial reocclusion.This 3-arm, adaptive, single-blinded, randomized contr...

Wu Y, Ding L, Shen Y, Gao X, Chen D, Huang X et al.

In vitro assessment of the inhibitory effect of antiplatelet drugs on platelet aggregation is frequently employed to guide personalized antiplatelet therapy in clinical practice. However, existing methods for detecting platelet aggregation rely heavily on high concentrations of exogenous agonists...

Gothelf I, Arie GB, Alguyan F, Shiloh A, Margalit D, Henkin L et al.

Emergent intracranial stenting (EICS) has demonstrated efficacy in managing intracranial stenosis in patients undergoing mechanical thrombectomy (MT) for acute ischemic stroke. However, an optimal pharmacological regimen balancing thrombosis prevention and hemorrhagic risk following stent deploym...

Djouani M, Dumont BL, Neagoe PE, Villeneuve L, Tardif JC, Gagnon D et al.

Neutrophils can release pro-inflammatory cytokines and neutrophil extracellular traps (NETs), leading to vascular thrombosis. Neutrophil-platelet interaction, a major component of thrombosis, is more pronounced in inflammatory pathologies, such as heart failure (HF). Recently, the platelet recept...

Rines I, Adeoye O, Barreto AD, Broderick J, Carrozzella J, Chen H et al.

The addition of direct thrombin inhibitors or glycoprotein platelet inhibitors to intravenous thrombolysis in patients undergoing endovascular thrombectomy for acute ischemic stroke may improve reperfusion rates and clinical outcomes.To investigate the safety and efficacy of these agents.This was...