Epithalon Research

Rahman OF, Lee SJ, Seeds WA

Therapeutic peptides are emerging as promising adjuncts in the management of orthopaedic injuries, grounded in their ability to modulate molecular signaling networks central to cellular medicine. By acting on key pathways such as PI3K/Akt, mTOR, MAPK, TGF-β, and AMPK, peptides exert influen...

Al-Dulaimi S, Thomas R, Matta S, Roberts T

Al-Dulaimi S, Thomas R, Matta S, Roberts T

Epitalon, a naturally occurring tetrapeptide, is known for its anti-aging effects on mammalian cells. This happens through the induction of telomerase enzyme activity, resulting in the extension of telomere length. A strong link exists between telomere length and aging-related diseases. Therefore...

Gatta M, Dovizio M, Milillo C, Ruggieri AG, Sallese M, Antonucci I et al.

Diabetic retinopathy (DR) is the most common complication of diabetes mellitus and a leading cause of vision loss. Short peptides, such as di-, tri-, and tetrapeptides, have various beneficial activities, including antioxidant, antimicrobial, and anti-inflammatory effects. This study aims to test...

Araj SK, Brzezik J, Mądra-Gackowska K, Szeleszczuk Ł

Epitalon, also known as Epithalon or Epithalone, is a tetrapeptide, Ala-Glu-Asp-Gly (AEDG), which was synthesized based on the amino acids composition of Epithalamin, a bovine pineal gland extract, prior to its discovery in pineal gland polypeptide complex solution. During the last 25 years, this...

Ullah S, Haider Z, Perera CD, Lee SH, Idrees M, Park S et al.

Telomerase is highly expressed in oocyte cumulus cells and plays a significant role in follicular development and oocyte maturation. In this study, we hypothesized that in vitro culture conditions may affect telomerase activity during in vitro embryo production (IVP) and that its activation may i...

Ivko OM, Trofimova SV, Trofimov AV, Sharkovich Z, Mogilev VA

The review presents the results of long-term research conducted by the staff of the Saint-Petersburg Institute of Bioregulation and Gerontology, dedicated to the study of the biological activity of peptide bioregulators at all levels of a living organism's organization. This review compares the f...

Lam CSP, Lund LH, Shah SJ, Voors AA, Erlinge D, Saraste A et al.

Inflammation is a key driver of heart failure with preserved left ventricular ejection fraction. AZD4831 inhibits extracellular myeloperoxidase, decreases inflammation, and improves microvascular function in preclinical disease models.In this double-blind phase 2a study (Safety and Tolerability S...

Lezhava T, Jokhadze T, Monaselidze J, Buadze T, Gaiozishvili M, Sigua T et al.

In the present study, on the one hand, the epigenetic modification of condensed "old" chromatin was determined, and on the other hand, the influence of peptide bioregulators (Ala-Glu-Asp-Gly-Epitalon; Lys-Glu-Asp-Ala-Livagen; Ala-Glu-Asp-Pro - Cortagen and Lys-Glu - Vilon) on condensed chromatin ...

Yue X, Liu SL, Guo JN, Meng TG, Zhang XR, Li HX et al.

The developmental potential of oocytes decreases with time after ovulation in vivo or in vitro. Epitalon is a synthetic short peptide made of four amino acids (alanine, glutamic acid, aspartic acid, and glycine), based on a natural peptide called epithalamion extracted from the pineal gland. It i...

Avolio F, Martinotti S, Khavinson VK, Esposito JE, Giambuzzi G, Marino A et al.

This study evaluates the effects of five different peptides, the Epitalon® tetrapeptide, the Vilon® dipeptide, the Thymogen® dipeptide, the Thymalin® peptide complex, and the Chonluten® tripeptide, as regulators of inflammatory and proliferative processes in the human mon...

Wiercigroch E, Swit P, Brzozka A, Pięta Ł, Malek K

The design of a sandwich-type SERS immunoassay (surface-enhanced Raman spectroscopy) is demonstrated operating in dual surface enhancement and dual-tag paradigm. The capture and detection antibodies are linked to two SERS-active substrates and form together the three-dimensional (3D) structu...

Ivko OM, Drobintseva AO, Leont'eva DO, Kvetnoy IM, Polyakova VO, Linkova NS et al.

It was verified new molecular targets of geroprotective activity of AEDG (epitalon) and KE (vilon) peptides by the method of confocal laser scanning microscopy. It was shown that the MitoTracker Red mitochondries staining decreased and L7A ribosomal protein synthesis compensatory increased during...

El-Tarabany MS, Saleh AA, El-Araby IE, El-Magd MA

This study aimed to screen intron 8 of the leptin receptor (LEPR) gene for polymorphisms in female Japanese quails. Two adjacent novel SNPs (A277G and A304G) were detected using PCR-SSCP and sequencing. These SNPs produced three haplotypes (AA/AA, AG/AG, and GG/GG) that were significantly (p&#x20...

Pinelis IS, Pinelis YI, Kuznik BI, Iordanishvili AK, Vasiliev MA

The article presents data on the use of peptide bioregulators of cell homeostasis and the protective functions of the body in various dental diseases and pathology of organs and tissues of the maxillofacial region. Issues related to the immunopharmacological effect and clinical use of natural and...

Khavinson V, Diomede F, Mironova E, Linkova N, Trofimova S, Trubiani O et al.

It was shown that AEDG peptide (Ala-Glu-Asp-Gly, Epitalon) regulates the function of the pineal gland, the retina, and the brain. AEDG peptide increases longevity in animals and decreases experimental cancerogenesis. AEDG peptide induces neuronal cell differentiation in retinal and human periodon...

Azmal SA, Bhuiyan AA, Omar AI, Ma S, Sun C, Han Z et al.

The improvement of egg production is of vital importance in the chicken industry to maintain optimum output throughout the laying period. Because of the elongation of the egg-laying cycle, a drop in egg-laying rates in the late laying period has provoked great concern in the poultry industry. In ...

El-Magd MA, Saleh AA, Nafeaa AA, El-Komy SM, Afifi MA

The insulin-like growth factor 1 (IGF1) gene is a member of the group of somatotropin axis genes that play a significant role in cell proliferation and growth of muscles. Here, we searched for polymorphisms in buffalo IGF1 and found two novel single nucleotide polymorphisms (SNPs), G64A and G280A...

Fedoreyeva LI, Dilovarova TA, Ashapkin VV, Martirosyan YT, Khavinson VK, Kharchenko PN et al.

Exogenous short biologically active peptides epitalon (Ala-Glu-Asp-Gly), bronchogen (Ala-Glu-Asp-Leu), and vilon (Lys-Glu) at concentrations 10-7-10-9 M significantly influence growth, development, and differentiation of tobacco (Nicotiana tabacum) callus cultures. Epitalon and bronchogen, i...

Yazdani Abyaneh MA, Engel P, Slominski A, Ragsdale B, Agag R, Cramer D et al.

Giant basal cell carcinomas (GBCCs), (BCC ≥ 5 cm), are often painless, destructive tumors resulting from poorly understood patient neglect.To elucidate etiopathogenic factors distinguishing GBCC from basal cell carcinoma (BCC) and identify predictors for disease-specific death (DSD).Case-c...