Kljajić M, Parać E, Atić A, Bašić-Jukić N
Background/Objectives: Uremic pruritus is a common complication in patients with end-stage kidney disease undergoing maintenance hemodialysis. Despite its high prevalence and substantial impact on sleep, psychological well-being, and overall quality of life, its pathophysiology remains multifacto...
International journal of clinical pharmacology and therapeutics··PMID: 41540819
Yoshida T, Tsujimoto M, Fujioka H, Irie Y, Kawakami S, Nakatani S et al.
To examine the effects of the oral uremic toxin absorbent AST-120 on the concentration of free and protein-bound indoxyl sulphate (IS) and to assess the effects of serum albumin in end-stage kidney disease (ESKD) patients undergoing hemodialysis.The study enrolled 37 ESKD patients who initiated h...
Chung YP, Chen YW, Huang CF, Weng TI, Yang RS, Liu SH et al.
Epidemiological data have shown a notably high co-occurrence of osteoarthritis (OA) and chronic kidney disease (CKD). The pathological mechanisms for CKD-associated OA still remain to be clarified. Uremic toxin Indoxyl Sulfate (IS), accumulated in CKD, may play a role in OA pathology. This study ...
Cell communication and signaling : CCS··PMID: 41530748
Zhang Y, Sun C, Wang Y, Zhang H, Fan Y, Zhao H et al.
The gut-liver-kidney axis has emerged as a central regulatory network orchestrating metabolic, immune, and inflammatory homeostasis across organ systems. At its core lies the dynamic interplay between gut microbiota and host metabolism. Dysbiosis and impaired intestinal barrier integrity facilita...
p-Cresyl sulfate (pCS) is a highly toxic uremic compound that is produced from tyrosine and phenylalanine in the gut and primarily excreted renally. In patients with kidney dysfunction, the accumulation of pCS can lead to the worsening of kidney disease and manifestation of organ toxicities. Vari...
Uremic toxins (UTs) are bioactive compounds that accumulate in chronic kidney disease (CKD) due to impaired renal clearance, exacerbating disease progression and cardiovascular (CV) complications. These toxins originate from endogenous metabolism, gut microbiota, and dietary intake and include pr...
Adynamic bone disorder, common in chronic kidney disease (CKD), results from reduced bone turnover, often due to medications such as calcimimetics or high-dose vitamin D analogs that induce low parathyroid hormone (PTH) levels. Numerous factors contributing to PTH hyporesponsiveness, which also i...
Nakano T, Kitazato Y, Ogawa T, Tokumaru K, Shintani Y, Yoshitake T et al.
Indoxyl sulfate (IS) is involved in the liver-kidney axis by inducing renal ferroptosis by selenium deficiency due to suppression of selenoprotein P (SEPP1) expression in the liver. IS concentrations were negatively associated with selenium concentrations and SEPP1 concentrations in serum from pa...
Primary hyperparathyroidism (PHPT), a common endocrine disorder, is often diagnosed in its asymptomatic stage. We report the case of a 79-year-old woman with Guillain-Barré syndrome (GBS) who developed progressive hypercalcemia, initially suspected to be immobilization hypercalcemia (IH). Ho...
Journal of the American Society of Nephrology : JASN··PMID: 40009460
Andrews TD, Day GS, Irani SR, Kanekiyo T, Hickson LJ
Cognitive impairment involves alterations to one's cognitive status that affects everyday life. Individuals with CKD, and particularly kidney failure, experience higher rates of cognitive impairment (20%-70%) compared with the general population. The highest prevalence is described in kidney fail...
The oral spherical carbon adsorbent (OSCA), AST-120, has demonstrated efficacy in slowing the progression of chronic kidney disease (CKD). This study assessed the impact of OSCA administration during predialysis CKD period on cardiovascular outcomes after dialysis therapy. We conducted a retrospe...
Hsu SN, Stephen LA, Phadwal K, Dillon S, Carter R, Morton NM et al.
Chronic kidney disease-mineral and bone disorder (CKD-MBD) presents with extra-skeletal calcification and renal osteodystrophy (ROD). However, the pathophysiology of ROD remains unclear. Here we examine the hypothesis that stalled mitophagy within osteocytes of CKD-MBD mouse models contributes to...
The therapeutic benefit of the oral adsorbent drug AST-120 in chronic kidney disease (CKD) is related to an indoxyl sulfate (IS)-lowering action. Diabetes and dyslipidemia might worsen kidney damage in CKD. However, it is not known whether AST-120 influences lipid abnormalities as well as renal f...
Yu YH, Im H, Park S, Song B, Park DK, Kim DS et al.
Uremic toxins resulting from chronic kidney disease (CKD) can cause cognitive and emotional disorders, as well as cardiovascular diseases. Indoxyl sulfate (IS) and p-cresol are notable uremic toxins found in patients with CKD. However, few studies have investigated whether reducing uremic toxins ...
Molecular medicine (Cambridge, Mass.)··PMID: 39217289
Zhou J, Zhang J, Xu F, Gao H, Wang L, Zhao Y et al.
Renal ischemia/reperfusion injury (IRI) is a major cause of acute kidney injury (AKI), which is associated with high incidence and mortality. AST-120 is an oral carbonaceous adsorbent that can alleviate kidney damage. This study aimed to explore the effects of AST-120 on renal IRI and the molecul...
Nanofibers containing activated carbon using poly(ethylene-co-vinyl alcohol) (EVOH) were prepared to remove indoxyl sulfate (IS) from the blood. IS is a urinary toxin that is highly toxic and triggers the progression of chronic kidney disease (CKD). Here, nanofibers containing activated carbon (A...
Kashiwagi Y, Okuno H, Nishida S, Ishii H, Yamanaka G
Patients with chronic kidney disease (CKD) sometimes experience gastrointestinal symptoms, such as nausea and vomiting. In addition, hypertension and CKD are closely linked, and sustained hypertension in children is associated with the progression of CKD, leading to early cardiomyopathy and prema...
Kidney research and clinical practice··PMID: 38389147
Cha RH
Inflammation, metabolic acidosis, renin-angiotensin system activation, insulin resistance, and impaired perfusion to skeletal muscles, among others, are possible causes of uremic sarcopenia. These conditions induce the activation of the nuclear factor-kappa B and mitogen-activated protein kinase ...
Wu CC, Tian YC, Lu CL, Wu MJ, Lim PS, Chiu YW et al.
Pruritus is a common and distressing symptom that affects patients with chronic kidney disease. The concentration of protein bounded uremic toxin was associated with the uremic pruritus. The aim is to assess the efficacy of AST-120 for uremic pruritus in hemodialysis patients.The participants wer...
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