Ecallantide Research

Butt MA, Kumar S, Sarwer SM, Manna D

We describe a 62-year-old female patient who presented to the Accident & Emergency (A&E) department with upper airway edema. Her past medical history included hypertension, obstructive sleep apnea, and ischemic heart disease. She had been previously hospitalized for a lower resp...

Sabharwal L, Purpora A, Gerstbrein D, Konrad K, Meisch B, Athanasiou N et al.

Acute gastroenteritis is caused by a variety of pathogens, including bacteria, viruses, and parasites, which may have overlapping clinical signs and symptoms. Community-acquired gastroenteritis is caused by various pathogens, while healthcare-associated gastroenteritis is caused by Clostridioides...

Li HH, Aygören-Pürsün E, Magerl M, Craig TJ, Manning ME, Hummel N et al.

The goal of on-demand treatment for hereditary angioedema attacks is to halt attack progression to minimize morbidity and mortality. Four on-demand treatments have been approved thus far (ecallantide, icatibant, recombinant human C1 esterase inhibitor [rhC1INH], and plasma-derived C1INH). Results...

Wang W, Zhang Y, Fang Y, Gao J, Thuku RC, Yang J et al.

The contact-kinin system plays a central role in the thromboinflammatory pathology of ischemic stroke. Modulating this pathway represents a promising strategy for the prevention and treatment of ischemic stroke. Based on our recent findings demonstrating that the short peptide SD6 (SLGASD), deriv...

Weinberg D, Gayda S, Hultz K, Atia H, Kohen B, Boccio E et al.

Hereditary angioedema (HAE) is a genetic disorder associated with recurrent episodes of angioedema in the absence of urticaria and pruritus. Hereditary angioedema is inherited in an autosomal dominant pattern and results in a quantitative deficiency (HAE type I) or dysfunction (HAE type II) of th...

Cohn DM, Soteres DF, Craig TJ, Lumry WR, Magerl M, Riedl MA et al.

Over the past 2 decades, guidelines for the on-demand treatment of hereditary angioedema attacks have undergone significant evolution. Early treatment guidelines, such as the Canadian 2003 International Consensus Algorithm, often gated on-demand treatment by attack location and/or severity. Pivot...

Rezvani-Sharif A, Lioe H, Dower SK, Pelzing M, Panousis C, Harvie DJE et al.

The kallikrein-kinin system (KKS) is a complex biochemical pathway that plays a crucial role in regulating several physiological processes, including inflammation, coagulation, and blood pressure. Dysregulation of the KKS has been associated with several pathological conditions such as hereditary...

Al-Adimi G, Bhakta V, Eltringham-Smith LJ, Shirobokov V, Sheffield WP

Ecallantide comprises Kunitz Domain 1 of Tissue Factor Pathway Inhibitor, mutated at seven amino acid positions to inhibit plasma kallikrein (PK). It is used to treat acute hereditary angioedema (HAE). We appended hexahistidine tags to the N- or C-terminus of recombinant Ecallantide (rEcall) and ...

Tachdjian R, Savic S, Fridman M, Frade JP, Fasehun M, Audhya PK et al.

Background: Hereditary angioedema (HAE) is characterized by recurrent and unpredictable episodes of subcutaneous and/or submucosal swelling. Objective: To characterize the real-world treatment burden associated with existing on-demand therapies, we analyzed administration-site adverse drug reacti...

Eraky AM, Wright A, McDonald D

Type-1 hypersensitivity reaction represents an acute IgE-mediated reaction that can cause life-threatening conditions, such as anaphylactic shock, angioedema, and airway obstruction. Other reactions that can mimic type-1 hypersensitivity reactions include IgE-independent mast cell degranulat...

Sun F, Wang W, Li Z, Li Y, Guo W, Kong Y et al.

Thrombotic diseases, such as myocardial infarction, stroke, and deep vein thrombosis, severely threaten human health, and anticoagulation is an effective way to prevent such illnesses. However, most anticoagulant drugs in the clinic have different bleeding risks. Previous studies have shown that ...

Yeich A, Elhatw A, Ashoor Z, Park K, Craig T

Hereditary Angioedema (HAE) attacks show an increased frequency and severity for pregnant and lactating females secondary to the hormonal changes. The diagnosis and management of HAE in pregnant and lactating females pose a challenge for physicians due to the rarity of the disease and the paucity...

Zhu H, Gong F, Ma P, Qian Y, He L, Chen L et al.

Excited-state intermolecular proton transfer (inter-ESPT) fluorescent probes responsive to specific bioactive molecules should be greatly promising for protein sensing, DNA mutation simulating and cellular process regulating. However, the inter-ESPT molecules are recessive ESPT fluorophores, whic...

Guo Y, Zhang H, Lai H, Wang H, Chong-Neto HJ, Valle SOR et al.

Hereditary angioedema (HAE) is a rare autosomal dominant genetic disease characterized by repetitive subcutaneous or submucosal angioedema, activation of the kinin system, and increased vascular permeability. C1-inhibitor (C1-INH) deficiency, the main mechanism of HAE pathogenesis, occurs when ab...

Valerieva A, Longhurst HJ

Hereditary angioedema (HAE) is a rare disease caused by mutations in the SERPING1 gene. This results in deficient or dysfunctional C1 esterase inhibitor (C1-INH) and affects multiple proteases involved in the complement, contact-system, coagulation, and fibrinolytic pathways. Current options for ...

Šimac DV, Štimac T, Novak S

Hereditary angioedema (HAE) is a disorder affecting bradykinin regulation presenting as recurrent cutaneous or mucosal swelling. Treatment options include plasma-derived or human-recombinant C1-inhibitor, icatibant, or ecallantide. Due to the lack of knowledge and experience on the topic, the tre...

Nilsson B, Persson B, Eriksson O, Fromell K, Hultström M, Frithiof R et al.

Most SARS-CoV-2 infected patients experience influenza-like symptoms of low or moderate severity. But, already in 2020 early during the pandemic it became obvious that many patients had a high incidence of thrombotic complications, which prompted treatment with high doses of low-molecular-weight ...

da Silva MF, de Araújo-Júnior JX, da Silva-Júnior EF, Heimfarth L, Martins-Filho PR, Quintans JSS et al.

Coronavirus disease 2019 (COVID-19) is a potentially fatal disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that preferentially infects the respiratory tract. Bradykinin (BK) is a hypotensive substance that recently emerged as one of the mechanisms to explain COV...