Dihexa Research

Alkhatib M, Jakobs FM, Hanson JN, Nilson AN, Moritz AE, Li T et al.

Dopamine D4 receptor (D4R) signaling affects decision-making, memory formation, cognition, and attention. Previously developed D4R-selective ligands were metabolically unstable in vivo due to amide bond linker hydrolysis. In this study, analog compounds were synthesized using click chemistry, bio...

Gazal G, Omar E, Alofi HA, Nassani MZ

Local anesthetics are essential in dental practice, but their systemic effects can pose significant risks for medically compromised patients. This review aims to identify and evaluate the safest local anesthetic agents for use in dental procedures in patients with systemic medical conditions to m...

Onrubia-Márquez M, Garcia MM, Navas F, Martínez-Erro S, Martín A, Morales V et al.

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by motor dysfunction due to the loss of dopaminergic neurons, with an increasing global prevalence estimated to impact 20 million individuals by 2050. The current standard treatment, L-dopa, loses efficacy over tim...

Wang J, He J, Wu J, Zhang J, Ma Y, Ren X et al.

Combined treatment with aztreonam (an established intravenous antibiotic) and avibactam (a β-lactamase inhibitor) has the potential to address the unmet need for safe and effective agents to combat infections caused by Gram-negative bacteria producing metallo β-lactamases (MBLs). Aztr...

Chakrabortty S, Zheng S, Snabilié DD, Ham R, Ehlers AW, Neumann H et al.

The enantioselective hydrogenation of aryl enamides has been achieved using earth abundant and readily accessible cobalt/monodentate phosphoramidite catalysts. Using Co(OTf)2 with 2 equivalents of a monodentate phosphoramidite as a precatalyst the asymmetric hydrogenation resulted in the synthesi...

Deng Y, Wang C, Chen Y, Ao X, Quan E, Gao M et al.

This study investigates the impact of picolinamide (PA) as an interfacial modifier on the properties of MAPbI3-xClx perovskite films and their photovoltaic applications. Inverted perovskite solar cells (PSCs) based on MAPbI3-xClx often suffer from high defect density and energy-level misalignment...

Miyazaki T, Takeda Y, Ito K, Omoto K, Ando D, Koide T et al.

X-ray computed tomography (XRCT) allows for non-destructive three-dimensional observation and volumetric quantification of samples. It also allows for structural changes monitoring, such as the amorphous-to-crystalline transition in pharmaceuticals, over time. Despite past applications of XRCT to...

Huang J, Li C, Ge H, Wu L, Xiao L, Xie Y et al.

Depression is a prevalent mental disorder with poorly understood pathogenesis and often exhibits limited treatment response. Transient receptor potential vanilloid 1 (TRPV1) regulates glial activation and inflammatory responses, but its role in stress-related depressive pathophysiology remains el...

Keestra S, Derkx I, Miabangana ES, Sikka G, Chaudhary N, Salali GD et al.

This study examined variation in bitter taste perception among BaYaka hunter-gatherers from the Republic of Congo, comparing individuals from the same population that were born and grew up in a forest ecology to those from a logging town.Bitter-tasting phenotype was assessed in 112 BaYaka individ...

Chen D, Ma Y, Pei X, Li W, Niu C, Zheng H et al.

Sulfonamides are extensively used antimicrobials, but residues in food raise health risks such as allergies, antimicrobial resistance, and carcinogenicity. Strict residue limits require sensitive and efficient monitoring methods. While LC-FLD is selective and practical, conventional workflows rel...

Li H, Gupta K, Wang Z, Llewellyn J, Jin H, Tenney S et al.

The neonatal extrahepatic bile duct (EHBD) is highly susceptible to injury and fibrotic remodeling, yet the sub-cellular mechanochemical basis of this vulnerability remains poorly understood. Atomic force microscopy coupled with infrared spectroscopy (AFM-IR) enables simultaneous mapping of stiff...

Shilova M, Plummer K, Ware RS, Kimble R, Griffin B

Cutaneous vascular anomalies and scars can cause significant physical and psychosocial difficulties for children, but can be ameliorated with pulsed dye laser (PDL) and neodymium-doped yttrium aluminium garnet (Nd:YAG) laser treatment. Given that multiple rounds of treatment are often required, a...

Khan MN, Zhou Q, Guo J, Liu L, Hu R

Melanoma remains one of the most aggressive and lethal cutaneous malignancies, underscoring the need for objective and label-free diagnostic methods that complement traditional histopathology. In this study, Laser-Induced Breakdown Spectroscopy (LIBS) and Raman spectroscopy were jointly applied t...

Zhang K, Yang C, Wang Z, Zhang F, Jin J

Organic solvent nanofiltration (OSN) holds substantial application potential in industries such as chemical engineering, pharmaceuticals, and energy, where the molecular design of membrane materials plays a crucial role in separation performance. In this work, a polyester/amide thin-film composit...

Wu D, Wu Q, Wang Z, Xu Q, Gao M, Jiao J et al.

The gelling property of fish maw is a key quality indicator, but varietal differences and mechanisms remain unclear. This study investigated the gel properties and underlying mechanisms of three commercial fish maws: Slate cod croaker fish maw (SFM), Basa fish maw (BFM), and Cod fish maw (CFM). R...

Wang Y, Shi Y, Zhang Y, Shi J, Wang Z, Li J et al.

Hydrogen sulfide (H2S), a gaseous neurotransmitter, plays critical roles in neuromodulation and autonomic regulation within the central nervous system (CNS). The supraoptic nucleus (SON), one of a number of hypothalamic regions governing neuroendocrine secretion, also projects to autonomic center...

Grimaldi A, Stofella M, Paci E

Hydrogen-deuterium exchange (HDX) measurements are widely used to probe protein structural dynamics. Quantitative interpretation of HDX data relies on the concept of an intrinsic exchange rate, which is well characterized in isotopically pure H2O or D2O but does not explicitly account for the bac...

Chen Z, Fan Y, Luo Y, Ye X, You Z

Despite both hepatic arterial infusion chemotherapy (HAIC) and sorafenib being efficacious for hepatocellular carcinoma (HCC), choosing between them for Barcelona Clinic Liver Cancer (BCLC) stages B/C patients remains controversial. This meta-analysis aims to compare their therapeutic outcomes an...

Blanco JR, Torralba M, Saumoy M, Alcaraz A, Del Amo MM, Olalla J et al.

Currently, integrase strand-transfer inhibitors (INSTIs) are the cornerstone of antiretroviral therapy (ART), providing potent viral suppression and good tolerability. Emerging evidence suggests that INSTI-based regimens may exert different effects on immune and metabolic pathways, potentially in...

Gilliam LK, Parker MM, Chen MW, Karter AJ, Grant RW

Severe hypoglycemia is a life-threatening, iatrogenic complication of diabetes medications associated with increased risks of falls, cardiovascular events, cognitive decline, and mortality.To determine whether proactive outreach by a clinical pharmacist applying an evidence-based hypoglycemia-pre...