Desmopressin Research

Sharma J

Enuresis, also known as nocturnal enuresis or bedwetting, refers to intermittent incontinence during sleep. It warrants medical attention, in children older than five years of age, or earlier if desired by the child or family, due to its significant emotional and psychological impact on quality o...

Berna-Erro A, Camello PJ, Granados MP, Delgado E, Fernández E, Teruel-Montoya R et al.

Store operated Ca2+ entry (SOCE) is altered in neonatal platelets with respect to adult platelets. Here, we aim to analyze the changes in STIMATE translation that leads to generating STIMATE-mustn1 and its possible involvement in SOCE in neonatal platelets. As a result, we have found different ex...

Cholesterol Treatment Trialists' (CTT) Collaboration. Electronic address: ctt@ndph.ox.ac.uk, Cholesterol Treatment Trialists' (CTT) Collaboration

Statin product labels (eg, Summaries of Product Characteristics [SmPCs]) list certain adverse outcomes as potential treatment-related effects based mainly on non-randomised and non-blinded studies, which might be subject to bias. We aimed to assess the evidence for such undesirable effects more r...

Carou-Senra P, Rial C, Richter A, Basit AW, Alvarez-Lorenzo C, Goyanes A et al.

Additive manufacturing offers unprecedented opportunities for personalized medicine, but most pharmaceutical printing platforms are optimized for milligram-range doses, limiting their suitability for microdosing. This work introduces a novel liquid deposition approach using a modified technical p...

Abdulsalam TA, Ali S

Insulin-associated edema is an uncommon but well-documented side effect of insulin therapy. It typically occurs with the initiation or rapid escalation in dosage of insulin, especially in patients who have experienced prolonged uncontrolled hyperglycemia. It is frequently overlooked and ma...

Yanagisawa S, Oikawa Y, Endo M, Kamei Y, Sugimura Y, Shimada A et al.

Gestational arginine vasopressin (AVP) disorder is classified into 3 categories: AVP deficiency (AVP-D), AVP resistance, and excess vasopressinase-induced AVP disorder. This is the first case report of gestational AVP disorder linked with magnesium sulfate administration.A 27-year-old woman pregn...

Sanusi OR, Otukoya E, Zaidan S, Geltzeiler M, Varlamov EV, Pandrangi V et al.

Surgery remains first-line therapy for most functioning pituitary adenomas (FPA). Remission rates are lower in some patients due to cavernous sinus invasion. Medial wall resection (MWR) may improve biochemical remission but remains largely underutilized. Our objective is to assess outcomes of MWR...

Alfonso DM, Aquino DA

Hyponatraemia remains the most prevalent electrolyte disturbance in heart failure, complicating clinical management and correlating with adverse outcomes. While traditionally viewed as a biomarker of disease severity, mounting evidence suggests that hyponatraemia reflects specific pathophysiologi...

Malreddy VR, Balmuri LM

We report a case of a 53-year-old woman with bipolar affective disorder on long-term lithium therapy who presented with confusion, acute right lower quadrant abdominal pain, fever, vomiting, and increased urinary frequency, with suspected urinary sepsis. Initial assessment revealed very high C-re...

Zamani MR, Imani B, Abbasi R, Karimi A, Moslehi S

One of the most common complications of rhinoplasty and septorhinoplasty is intraoperative bleeding, which poses challenges for both surgeons and patients. This systematic review and meta-analysis aimed to evaluate the effectiveness of various bleeding control methods in rhinoplasty and septorhin...

Volkert M, Dinh HA, Scholl UI, Stölting G

The zona glomerulosa (ZG) of the adrenal cortex regulates blood pressure and electrolyte homeostasis through aldosterone production. In ZG cells, potassium and angiotensin II (Ang II) trigger calcium oscillations that drive aldosterone synthesis. Changes in serum osmolality also modulate aldoster...

Ikegawa K, Fujimoto M, Aoyama K, Nakayama H, Kubota T, Nagasaki K et al.

Congenital nephrogenic diabetes insipidus (CNDI) is characterized by resistance of the distal nephrons and collecting ducts to arginine vasopressin (AVP). High doses of 1-deamino-8-D-arginine vasopressin (DDAVP), a V2-receptor-selective agonist, are effective in some cases. The present study aime...

Ata S, Yener S

Nocturnal enuresis is defined as involuntary urination during sleep in children, particularly those aged 5 years or older. Primary monosymptomatic nocturnal enuresis (PMNE) involves nighttime wetting without daytime symptoms, and although factors like reduced bladder capacity, nocturnal polyuria,...

Adepoju VA, Abdulrahim A, Olaniyi BO, Adnani QES, Biswas S

Background: Postpartum haemorrhage (PPH) remains the leading cause of maternal mortality globally. Women with inherited or unexplained bleeding disorders such as von Willebrand disease (VWD), factor XI deficiency (FXI), platelet function disorders, or bleeding disorder of unknown cause (BDUC) fac...

Caputo C, Tomar N, Beitner S

Arginine vasopressin deficiency (AVP-D) is a rare disorder associated with a considerable risk of dysnatremia. This case involves a 59-year-old woman with idiopathic AVP-D and secondary hypocortisolemia, who developed severe hyponatremia after elective knee replacement. Postoperative pain managem...

Villegas S, Jenniches D, Young S, Yin Y, Noorbakhsh MR

Platelet dysfunction in the setting of intracranial hemorrhage may potentiate worsening hemorrhage. Desmopressin may be used to treat platelet dysfunction in intracranial hemorrhage through von Willebrand factor release. Hypertonic saline is often used in this population to treat cerebral edema a...

Yan T, Hu D, Wang N, Lin Z, Li S, Wang M et al.

Severe burns trigger sustained hypermetabolism marked by protein hypercatabolism, insulin resistance, and relative insulin deficiency. These effects are exacerbated in diabetic patients, increasing susceptibility to acute metabolic crises.We report the first case of a burn patient with type 2 dia...

Sharma A, Mathew B, Gupta D, Gahlot GPS

Granulomatous hypophysitis is a rare form of pituitary inflammation that closely mimics pituitary macroadenoma in clinical presentation as well as radiological appearance. Histopathology remains the gold standard diagnostic modality. Here, we present the case of a young female who presented with ...

Maynard S, Bye AP, Desborough MJR

Antiplatelet drugs are used for treatment of arterial disease, but side effects include an increased risk of bleeding. For patients with intracerebral hemorrhage, traumatic brain injury, and lower gastrointestinal bleeding, mortality rates are higher for patients taking antiplatelet drugs. Revers...

Chen JJ, Lee TH, Lai PC, Tu YK, Hsu HH, Yang HY et al.

Desmopressin was hypothesised to prevent post-kidney biopsy bleeding; however, its efficacy in reducing bleeding and bleeding-related complications has yet to be systematically examined.Relevant studies from online electronic databases up to 15 May 2025 were identified. Randomised controlled tria...