Human Beta-Defensin Research

Jacobo-Delgado YM, Huerta-Elías JE, Cabral-Venegas V, García-Hernández M, Rivas-Santiago B

Human β-defensin 3 (hBD-3) is a multifunctional host defense peptide with exceptional antimicrobial, immunomodulatory, and tissue-repair properties. Beyond its potent activity against gram-positive and gram-negative bacteria, fungi, and selected viruses, hBD-3 plays a central role in epithe...

Hakim MS

Chikungunya virus (CHIKV) infection is a re-emerging arboviral disease in tropical and subtropical regions. In addition to acute febrile syndrome, CHIKV infection may lead to chronic articular manifestations that significantly affect a long-term quality of life. This study aimed to design a unive...

Kaya NE, Kurmuş GI, Özdemirel AE, Altunay E, Gönül M

Human beta-defensin 2 (hBD-2) is an antimicrobial peptide upregulated by IL-17A and TNF-α, important in skin immunity and inflammation. While hBD-2 is elevated in psoriatic skin, its systemic expression and clinical significance remain unclear, particularly in psoriatic arthritis (PsA).To c...

Yamamoto Y, Morozumi T, Yokoo T, Takahashi T, Saruta J, Tsuchihashi H et al.

Background/Objectives: Oral microbial homeostasis is crucial for overall health. Nonetheless, the relationship between probiotics and the oral environment remains unclear. This study investigated the association between continuous consumption of yogurt containing Lactobacillus delbrueckii ssp. bu...

Tumkur Shivakumar A, Mahadevaiah Neelambike S, R Shettar S, Megha GK, Halasabalu Kalgeri S, D Shiragannavar V et al.

Oral diseases such as caries and periodontitis are complex, multifactorial diseases and remain the most prevalent worldwide. Both diseases are associated with vitamin D deficiency (VDD) and its pathophysiological process. The prevalence of metabolic syndrome (MetS) is rising in developing countri...

Fadhila O, Ridwan RD, Yastuti WTP, Yuliati, Diyatri I, Margaretha SA et al.

Dental caries and periodontitis are among the most prevalent oral diseases, primarily caused by Streptococcus mutans, Lactobacillus acidophilus, Aggregatibacter actinomycetemcomitans, and Porphyromonas gingivalis. Metabolites from stem cells from human exfoliated deciduous teeth (SHED) expressing...

Kodori M, Farhadi N, Jafari GA, Afkhami H, Yousefi MH

Extensive research has investigated the therapeutic potential of mesenchymal stem cells (MSCs) in treating infectious diseases and mitigating tissue damage caused by these diseases. MSCs, along with their exosomes, present a promising avenue for combating infectious diseases, particularly HACEK e...

Sharma A, Kumar M, Yadav E, Kumar S, Goyal M, Rastogi S et al.

The aim of this study was to compare the presence of human ß defensin-2 (hBD-2) in GCF and microbial flora in the subgingival plaque, among the patients treated with fixed orthodontic braces and aligners.Samples of GCF and subgingival plaque were collected from 170 patients (85 conventional ...

Koufakis T, Kouroupis D, Kourti A, Karalazou P, Thisiadou K, Georgiadis I et al.

Obesity is characterized by chronic inflammation and gut dysbiosis, yet circulating markers reflecting intestinal immune activation remain limited. Regenerating islet-derived protein 3 alpha (REG3α), an antimicrobial peptide secreted by intestinal Paneth cells, plays a pivotal role in mucos...

Yepes G, Tang HC, Holdsworth N, Salamon K, Schwartz L, Ching C et al.

Recurrent urinary tract infection (rUTI) is a major diagnostic and management challenge. Dysregulated innate immune responses, including antimicrobial peptides and cytokines, may underlie UTI susceptibility. This study investigates whether urinary concentrations of antimicrobial peptides and cyto...

Allemailem KS

Background: Chromobacterium violaceum is an emerging multidrug-resistant (MDR) Gram-negative bacterium associated with severe septicemia, abscess formation, and high mortality, particularly in immunocompromised individuals. Increasing antimicrobial resistance and the absence of approved vaccines ...

Du Y, Yu Z, Sheng W, Li Y, Hou L, Zheng Y et al.

Cytokine storm is a critical driver of acute respiratory distress syndrome and multiple organ failure. Human β-defensin 2 (HBD-2) is the first inducible defensin discovered in human body. Defensin can resist pathogenic microorganisms invading the body through direct bactericidal effect and ...

Kumar S, Gupta A

Obesity, type 2 diabetes (T2D), and insulin resistance are pervasive metabolic disorders marked by chronic low-grade inflammation and systemic metabolic disorders. The emerging field of immunometabolism highlights how interactions between immune processes and metabolic pathways in adipose tissue,...

Dall'Olio E, Andrani M, Baratta M, Rensis F, Saleri R

Mastitis remains a prevalent and economically detrimental disease within the dairy industry, profoundly affecting animal welfare, milk quality, and overall production output. Nowadays, Somatic Cell Count (SCC) is widely recognized as the gold-standard indicator for the detection of mastitis; howe...

Agarwal S, Kumar S, Prabhan SS, Kapoor S, Singh S, Bothra M et al.

Hemoglobinopathies are common genetic disorders that can affect neonates. This study aimed to evaluate the prevalence of various hemoglobin variants in newborns and identify diagnostic cutoff levels for predicting homozygosity for HbS and HbD using capillary electrophoresis and molecular sequenci...

Li L, Diao J, Wang F, Wang X, Liu Y, Fu X et al.

Adipose-derived mesenchymal stem cells (ADSCs) have been widely investigated for their pro-angiogenic and immunomodulatory roles in the repair of infected wounds. However, the direct antimicrobial effects of ADSCs and the underlying regulatory mechanisms remain poorly characterized. In particular...

Ira NI, Jaishee N, Saha A, Naidoo D, Islam ST, Tani TH et al.

Sindbis virus (SINV), belonging to the genus Alphavirus, is the causative agent of Pogosta disease in humans. The clinical infection is characterized by fever, malaise, rash, myalgia, and arthralgia, which is generally self-limiting. Chronic infection with SINV triggers autoimmune conditions that...

Barclay AM, Ninaber DK, Walburg KV, Hiemstra PS, Ottenhoff THM, van der Does AM et al.

Repeated exposures to Mycobacterium tuberculosis (Mtb) and related species may influence host responses, which in turn may affect vaccine efficacy and could even render the host less or more susceptible to progression to active tuberculosis (TB) disease.Using well-differentiated primary human bro...

Fernández-Torres J, Zamudio-Cuevas Y, Martínez-Flores K

Ankylosing spondylitis (AS) is a chronic inflammatory disease with a strong genetic component, frequently accompanied by extra-articular manifestations such as acute anterior uveitis (AAU). This study aimed to evaluate the association of the rs11362 and rs1800972 (DEFB1), and rs3806268 and rs1075...

Tack C, Van den Houte K, Besard L, Capiau L, Ceulemans S, Gernay O et al.

The role of low-grade-inflammation in Irritable Bowel Syndrome (IBS) a common disorder of gut-brain interaction is unclear. Association with symptom severity, as well as effects of first line treatments are understudied. In a large cohort of primary care IBS patients (DOMINO trial), a FODMAP-lowe...