Human Alpha-Defensin Research

Schwitter AM, Yasuda T, Li X, Sugihara K

Antimicrobial peptides (AMPs) are promising agents against infections caused by multidrug-resistant bacteria. Notably, the human AMPs LL-37 and α-defensin (HNP1) exhibit a cooperative effect, synergistically killing bacteria while reducing host cytotoxicity. However, the structural-function...

Bonazzi E, Hao F, Patterson AD, Peyrin-Biroulet L, Jensen BAH, Chassaing B et al.

The gastrointestinal tract hosts a diverse microbial community, named the intestinal microbiota, which plays a vital role in gut health. Host defense peptides (HDPs), such as defensins, help regulate interactions between the host and its microbiota. Dysfunction in HDPs expression has been associa...

Zhu K, Xiang J, Lu F, Wang J, Zhang Y, Feng H et al.

This study aimed to investigate the effect of Lactobacillus gasseri SBT2055 (LG2055) on non-alcoholic fatty liver disease (NAFLD). Mice were fed with high-fat diet (HFD) to establish NAFLD animal model. HFD mice were administrated with LG2055 gavage to explore the role of LG2055 on NAFLD. This st...

Liao C, Yao D, Sun Z, Ericksen B, Jiang B, Zhou Y et al.

Staphylococcus aureus is a major opportunistic pathogen whose ability to form biofilms significantly enhances its persistence and antibiotic resistance. We previously found that human neutrophil peptide 1 (HNP1), a member of the α-defensin family, promotes biofilm formation in Acinetobacter...

Feng J, Chen S, Li Q, Long Y, Ma Y, Zhang L et al.

Reliable tools for early identification of Crohn's disease (CD) remain lacking. We analyzed 2736 plasma proteins in 39,634 UK Biobank (UKB) participants and identified 44 associated with incident CD. CD274, CHI3L1, REG1B, ITGAV, PRSS8, ITGA11, GDF15, DEFA1_DEFA1B, and IL6 ranked highest in protei...

Lafleur JE, Shaykhinurov E, Perkins J, Wargowsky R, Jaatinen K, Pasquale M et al.

The chances of survival from sepsis are improved by early diagnosis and treatment. In the prospective SENSOR study, RNA biomarkers of innate immune neutrophil activation were examined in emergency department (ED) patients triggering an automated sepsis alert. We hypothesized that higher levels of...

Yakobi SH, Nwodo UU

Escalating antimicrobial resistance necessitates the development of alternative therapeutics that circumvent conventional enzymatic and efflux-based defence systems. Antimicrobial peptides (AMPs) represent a compelling class of innate immune effectors, however, their clinical translation is hinde...

M'Koma AE

Background/Objectives: Indeterminate colitis (IC) is an erroneous diagnosis for predominantly colonic inflammatory bowel disease (IBD) when there is a non-definitive foundation of the benchmark for ulcerative colitis (UC) and Crohn's colitis (CC) after a combined state-of-the-art classification s...

Sadeeq M, Wang C, Yu K, Cui S, Bian L, Hou F et al.

The escalating crisis of antimicrobial resistance demands novel therapeutics that overcome the limitations of conventional antibiotics. Human α-defensins, such as Human Neutrophil Peptide-1 (HNP-1), represent compelling candidates due to their potent, broad-spectrum antimicrobial activity a...

Helmy M, Li JU, Yan XF, Meade RK, Anderson E, Chen PB et al.

We present a collection of 17 high-quality long-read inbred mouse strain genomes with complete annotation (contig N50s of 0.8-33.9 Mbp). This collection includes 12 widely used classical laboratory strains and 5 wild-derived strains. We have resolved previously incomplete genomic regions, includi...

Vidal CMP, Rysavy O, Kulanthaivel S, Zeng E, Cavalcanti B, Carrilho MR et al.

This study investigated the proteomic landscape of sound and carious coronal dentin to uncover the molecular signatures of host response, including tissue degradation, inflammation, and repair, across progressive stages of caries lesions. Dentin from deidentified human molars, grouped into 6 clus...

da Silva EM, Cipelli M, do Amaral MA, Pacheco-Silva A, Câmara NOS, Andrade-Oliveira V et al.

Colorectal cancer (CRC) is the fourth most common and the third mostly deadly cancer globally. Even with alternative therapies, some patients do not respond to treatment. Identifying modulations in the tumor microenvironment (TME) of CRC is a significant challenge due to the complex and dynamic n...

Gonzalez-Ruiz J, Sarmiento-Casas M, Bahena-Ocampo I, Espinosa M, Ceballos-Cancino G, Vazquez-Santillan K et al.

Pancreatic Ductal Adenocarcinoma (PDAC) is one of the most aggressive and lethal malignancies, driven by late diagnosis, limited therapeutic options, and high metastatic potential. Beyond their canonical roles in hemostasis, platelets have emerged as active modulators of tumor progression and pro...

Rodrigues JM, Ferreira Leal AP, Buccini DF, Franco OL

Inflammatory bowel diseases (IBDs) are chronic disorders affecting the gastrointestinal tract, causing severe inflammation and tissue damage. Current treatments often have adverse effects, underscoring the need for alternatives. This article is a short review of host defense peptides (HDPs), whic...

He Z, Xie J, Yan FL, Geng LY, Zhang YX, Liu JJ et al.

Background: This study aims to investigate whether elevated human neutrophil peptides 1-3 (HNP 1-3) levels in cerebrospinal fluid (CSF) are associated with disease severity and clinical outcomes in patients with intracerebral hemorrhage (ICH). Materials and Methods: HNP 1-3 levels were measured i...

Schweizer S, Wang X, Paxman C, Mueller JF, Vetter W

Passive air samplers are well-suited for monitoring persistent organic pollutants (POPs) in ambient air. While the presence of POPs had been documented in Australian air, no data existed on structurally similar, halogenated natural products (HNPs), although these were frequently found in marine b...

Zhang S, Rajadhyaksha EA, Syed F, Canas J, Saxena V, Schwaderer AL et al.

DNA copy number research is impeded by limited methodology to determine true DNA copy numbers accurately and precisely. Human alpha defensin 1-3 (DEFA1A3) is a multiallelic gene with DNA copy numbers generally ranging from 2 to 12 copies per diploid genome. In this study, we developed a digital d...

Krat AV, Zamay GS, Veprintsev DV, Kirichenko DA, Kolovskaya OS, Zamay TN et al.

Background: The detection of circulating tumor cells (CTCs) holds significant promise for the diagnosis and monitoring of lung cancer (LC). However, the clinical utility of CTCs is limited by the heterogeneity of their phenotypes and the shortcomings of existing detection methods, which often rel...

Sibi JM, Shruthi S, Mohan V, Babu S, Aravindhan V

Childhood exposure to filariasis can confer significant protection against diabetes which is called as "Metabolic Hygiene Hypothesis". However, the effect of diabetes on anti-filarial immunity is not much studied. In the present study, the role of diabetes on systemic anti-filarial immunity was e...

Yurtseven E, Baysal K, İncir S, Canbaz AA, Veznikli M, Baygul A et al.

Subclinical atherosclerosis is a key predictor of cardiovascular events. While inflammation plays a crucial role in atherosclerosis, the involvement of Human Neutrophil Peptides 1-3 (HNP1-3) in its progression remains unclear. The study investigates the association of HNP1-3 and PCSK9 with corona...