Daptomycin Research

Park K-H, Jung J, Shin SU, Jeong SJ, Park DW, Kim D-M et al.

Methicillin-resistant Staphylococcus aureus (MRSA) bacteremia is a serious clinical challenge due to limited treatments and high mortality. We conducted both preclinical and clinical studies to assess the potential role of delpazolid in combination with vancomycin. Synergistic effects of delpazol...

Carrasquel M, Quasem K, Patterson T, Samir E, Farnum C

Vancomycin is a first-line antibiotic used for severe gram-positive infections, but it may rarely trigger immune-mediated small-vessel vasculitis. We report a case of a 43-year-old man with end-stage renal disease on home hemodialysis who developed palpable purpuric skin lesions three days after ...

Soo JZY, Lim TP, Ho JJY, Tong SYC, Lye DC, Davis JS et al.

Combination antibiotic therapy may improve treatment success for bacterial infections, but bacterial strain-to-strain variability in synergy and its clinical impact remains unclear. This study evaluated whether positive in vitro interactions (synergy or additivity) between vancomycin or daptomyci...

Sui Y, Horsfall AJ, Harris PWR

Kynurenine (Kyn), a key metabolite in the kynurenine pathway, has emerged as an important motif in natural peptides with diverse biological activities. This review explores the growing number of Kyn-containing peptides discovered and the importance of Kyn for biological activities. While daptomyc...

Maraki S, Mavromanolaki VE, Kasimati A, Iliaki-Giannakoudaki E, Stafylaki D

Otitis is a very common infection, mainly affecting children, and the main indication for prescribing antibiotics. This study investigated the epidemiology and antibiotic resistance profile of bacterial pathogens asso-ciated with otitis in patients of all ages in Crete, Greece.From January 2013 t...

Tiesenga A, Birris TR, Schreiner W, Malaka D, Woods R, Wang MS et al.

We report a case of a 55-year-old male with a history of Crohn's Disease who presented for acute on chronic worsening back pain. He was found to have spondylodiscitis with adjacent myositis secondary to an uncommon urinary tract infection pathogen, Actinotignum schaalii. He underwent intervention...

Zaydman MA, Glaser L, Herman DS, Kressloff M, Azimi V, Lockowitz CR et al.

Systemic shifts in antimicrobial resistance rates can be due to epidemiologic shifts in microbial susceptibility patterns or artifactual shifts introduced by technical biases in antimicrobial susceptibility testing (AST)-both ultimately leading to changes in antimicrobial prescribing. To reduce t...

Rutare S, Masaisa F, Nkubana T, Dusabe A, Munyemana JB

Methicillin-resistant Staphylococcus aureus (MRSA) remains a significant global public health challenge, particularly as a leading cause of nosocomial infections in intensive care units (ICUs). While MRSA prevalence is well documented in many settings, its burden at the University Teaching Hospit...

Mohammad S, Aljumaa SA, Ghazal H, Alnamous A, Al Dhaheri R, Almangour TA et al.

MRSA bacteremia is associated with substantial clinical burden. Ceftaroline (CPT)-based combinations with vancomycin or daptomycin are increasingly utilized, but their added benefit remains uncertain. This meta-analysis compared the effectiveness and safety of CPT-based combination therapy versus...

Wilson RC, Gilchrist MJ, Cele R, d'Arc S, Mills EA, Ndhlovu C et al.

Notwithstanding the wide uptake of outpatient antimicrobial therapy (OPAT) in the UK, there is a paucity of data on antimicrobial exposure. We aimed to assess antimicrobial pharmacokinetic-pharmacodynamics (PK-PD) for several agents in our service with a view to understanding a potential role for...

Rehan MA, Bagwell JT, Wachter SB, Jubbal SS

Lactobacilli are Gram-positive, facultatively aerobic, rod-shaped bacteria that are a normal part of the human microbiota and rarely cause infections in immunocompetent hosts. Lactobacillus casei and Lactobacillus rhamnosus are the most common human pathogens within this genus and are also freque...

Shahmorad A, Hashemi R, Rajabi M

In this study, a new class of three-dimensional (3D) printed metamaterials with auxetic behavior was designed, fabricated, and experimentally analyzed under impact loading conditions. The metamaterials were created by combining multiple unit cells—honeycomb, tetra-chiral, and cubic—...

Šubrtová P, Rozsívalová P, Halvová P, Maláková J, Paterová P, Ryšková L et al.

Current recommendations for daptomycin dosing are based on body weight. However, it can be hypothesized that dosing based on renal function may improve the attainment of recommended pharmacokinetic (PK)/pharmacodynamic (PD) targets. The aim of this study was to develop a population pharmacokineti...

Airaud C, Demay E, Dias Meireles V, Luque Paz D, Tattevin P, Lazaro P et al.

Daptomycin is increasingly used to treat Gram-positive infections, but carries a risk of muscle toxicity. Despite guideline recommendations, real-world adherence to safety monitoring remains poorly documented.To evaluate daptomycin prescribing practices and identify risk factors for muscle toxici...

Arnold JC, Druten E, Kowal R, Szatkowski J, Lopas LA

A 44-year-old woman with an infected pilon fracture nonunion developed Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) after prolonged intravenous vancomycin and implantation of a vancomycin/tobramycin-loaded antibiotic cement spacer (ACS). Fevers, rash, and eosinophilia persisted d...

Gomez-Villegas SI, Miller WR, Arias CA

Vancomycin-resistant enterococci (VRE) are major health care-associated pathogens and significantly contribute to patient morbidity and mortality, particularly in immunocompromised and critically ill patients. The clinical management of VRE infections is challenging due to limited therapeutic opt...

Deng F, Ke L, Huang M, Chen M, Chen Z, Mu P et al.

The molecular mechanism by which deoxynivalenol (DON) induces bacterial antibiotic resistance remains unexplored. As the most prevalent mycotoxin contaminant, DON poses significant public health risks due to the absence of dedicated monitoring standards in probiotic products. This study uncovers ...

Azzam A, Khaled H, Salem A, Sayed M, Mohieldein A, Elsayed MS et al.

Methicillin-resistant Staphylococcus aureus (MRSA) is a major public health concern, particularly in resource-limited settings such as Africa. This meta-analysis aimed to determine the proportion of MRSA among S. aureus isolates from patients with confirmed infections and to assess associated ant...

Di Bella S, Geremia N, Pea F, Zeitlinger M, Sanson G, Monticelli J et al.

Subcutaneous antibiotic administration is increasingly recognized as a valuable alternative to intravenous therapy in selected clinical contexts. It is particularly advantageous for patients with poor venous access, frail or cachectic individuals, and in outpatient or palliative care settings, wh...