Victims of child sexual abuse (CSA) are at greater risk of developing psychopathology in adulthood. Most research on CSA has focused on female survivors, while the experiences of male survivors have been comparatively understudied. Consequently, factors that contribute to the mental health outcom...
Structural gray matter changes were significantly observed in cognitively normal elderly adults, but the associations between different structural brain patterns, executive function, and general cognitive ability in older adults have not been fully explored.A total of 119 cognitively normal elder...
Gabel M, Knauss A, Liu Y, Mohamed Abdou M, Kaufmann C, Loges L et al.
The treatment of inflammatory bowel disease (IBD) is still challenging. Therefore, it is crucial not only to develop new drugs specifically targeting IBD but also to evaluate the application and efficacy of already established pharmaceuticals used for related disorders. A promising new candidate ...
Cubilier E, Taghavi M, De Prez E, Jacobs L, Sinaeve S, Nortier J et al.
Pro-inflammatory and pro-thrombotic stimuli can activate endothelial cells (ECs) and predispose them to thrombotic microangiopathies (TMAs). Drug-induced TMA (DITMA) may occur in clinical practice during treatment with interferon-β1a (IFN-β1a), ciclosporin A (CsA), and gemcitabine (GE...
Emerzian SR, Johannesdottir F, Lee DC, Wu IH, Jangolla SVT, Yu MG et al.
The increased hip fracture risk in individuals with type 1 (T1D) and type 2 (T2D) diabetes is not explained by areal BMD (aBMD), indicating that diabetes increases fracture risk through mechanisms independent of aBMD. To investigate, we used QCT to compare femoral strength, volumetric BMD (vBMD),...
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation··PMID: 41704135
de Sousa MV, Carneiro LMC, Mazzali M, Surita FG, Costa ML, Guida JPS et al.
Chronic kidney disease can reduce fertility, but fertility may improve after transplant. Posttransplant pregnancy carries risks like preeclampsia, miscarriage, and prematurity. Although pregnancy is an immune-tolerant state, changes in immunosuppressive drugs during pregnancy can increase graft r...
To analyze current experimental and clinical studies regarding the role of calcium dysregulation in the pathogenesis of AP and to evaluate the efficacy of various pharmacological approaches to its correction.A literature review was conducted using PubMed, Scopus, and Google Scholar databases up t...
Zidan AA, Gad AYS, Zakaria NH, El-Hariri HM, Elsharnouby NM, Helmy MW et al.
COVID-19 severity is strongly associated with hyperinflammation. Cyclosporine A (CSA), an interleukin-2 inhibitor with immunomodulatory and antiviral activity, has been proposed as a potential adjunctive therapy. This study evaluated the safety and efficacy of CSA in patients with moderate to sev...
Peucedanum japonicum Thunb. (PJ), also known as costal hog fennel, is an edible medicinal plant recognized for its potential health benefits. We previously demonstrated the protective effects of PJ against muscle atrophy in young mice. In the present study, we investigated whether PJ also inhibit...
AlQusaimi R, AlRujaib F, AlSharhan F, Alassaf S, Khoursheed L, Abdulrahman F et al.
Chronic plaque psoriasis is a common immune-mediated inflammatory skin disease; however, facial involvement is relatively uncommon and may present diagnostic and therapeutic challenges. Facial psoriasis can mimic other inflammatory dermatoses and may demonstrate variable responses to systemic the...
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare, life-threatening mucocutaneous reactions. Pediatric mortality is lower than in adults, but children face higher risks of recurrence and long-term sequelae. Despite disease severity, pediatric-specific guidelines remain ...
Journal of applied physiology (Bethesda, Md. : 1985)··PMID: 41696846
Zambolin F, Vikmoen O, Cumming KT, Skattebo Ø, Ødemark HN, Øfsteng SF et al.
Background: Blood flow restriction (BFR) allows exercise at lower external load with similar or greater improvements compared with traditional training in non-trained individuals. However, the effect in well-trained competitive athletes is unclear. The aim of this study was to compare effort-matc...
Hemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory syndrome caused by unregulated immune activation, leading to a "cytokine storm" and multisystem failure. In people living with HIV (PLWH), it is frequently triggered by opportunistic infections like Mycobacterium tuberculosis....
Ahmed S, Moniruzzaman M, Ahmad S, Nipun NM, Ahamed MJ, Hafiz M et al.
Background Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy, caused by median nerve compression within the carpal tunnel, leading to pain, numbness, and functional impairment. Nerve conduction studies (NCS) remain the diagnostic gold standard, while ultrasonography (US) offer...
Thrombopoietin receptor agonists combined with anti-thymocyte globulin (ATG) and cyclosporine (CsA) are the standard immunosuppressive therapy (IST) for severe/very severe aplastic anemia (SAA/VSAA). However, early response rates remain suboptimal. Cyclophosphamide (CTX) has shown efficacy in rel...
Gastric ultrasound (GUS) plays a key role in identifying delayed gastric emptying and preventing pulmonary aspiration. Conventional GUS estimates gastric volume by measuring the cross-sectional area (CSA) of the antrum in the right lateral decubitus (RLD) position, which is often impractical in r...
The success of solid organ transplantation (SOT) and the use of immunosuppressants provide patients with terminal conditions hope. Acute immune rejection (AR) in SOT patients, however, has become more noticeable. Our study examined the relationship between AR and patient survival in a variety of ...
Osteoarthritis (OA) is a progressive degenerative disorder driven by complex pathogenic mechanisms. Increasing evidence indicates that NLRP3 inflammasome-mediated chondrocyte pyroptosis contributes critically to OA progression. Cellular repressor of E1A-stimulated gene 1 (CREG1), a secreted glyco...
Clinical and experimental nephrology··PMID: 41692880
Nakagawa N, Hiromura K, Isaka Y
Primary membranoproliferative glomerulonephritis (MPGN) is a rare progressive kidney disease that often leads to end-stage kidney disease. Our previous nationwide registry study (Report 1, 2015-2018) characterized initial demographics and treatment patterns. In this study (Report 2), we aimed to ...
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