Corticotropin Research

Li S, Wang J, Feng G, He J, Li K, Liu L et al.

Electrooxidation of sterols is recognized as a promising approach for synthesizing value-added steroid hormone pharmaceuticals. However, enhancing current density while delivering market-required steroidal carbonyl products with high selectivity remains a significant challenge. Herein, we report ...

Abelson JL, Clark SL, Sánchez BN, Mayer SE, Stalder T, Liberzon G et al.

Salivary cortisol measures and hair cortisol concentration (HCC) have been extensively used in epidemiological work to document links between stress biology and health. Though their value as stress biomarkers is well-established, little prior work grounds these field-friendly cortisol measures in...

Vardaki K, Maniadaki I, Galanakis E, Bitsori M

Idiopathic nephrotic syndrome (NS) is the most common glomerular disease in children. While corticosteroids remain the first-line treatment for inducing remission, their prolonged or frequent use can suppress the hypothalamic-pituitary-adrenal (HPA) axis, potentially leading to adrenal insufficie...

Korkmaz Yilmaz M, Sehit Burhan H, Burhan S, Niyazoglu M, Hatipoglu E

Cushing's disease (CD) is characterized by chronic hypercortisolism and is associated with persistent metabolic, psychological, and neurocognitive disturbances. While metabolic consequences are well described, the impact of disease activity and remission on eating behavior remains insufficiently ...

Izuchi T, Iwama S, Yamagami A, Kobayashi T, Suzuki K, Murase T et al.

The corticotropin-releasing hormone (CRH) stimulation test is used to diagnose adrenocorticotropic hormone (ACTH) deficiency; however, the serum cortisol cutoff value indicating impaired response on this test (18 µg/dL [approximately 500 nmol/L]) was established from the insulin tolerance te...

Becchi S, Burton CL, Tsoukalas M, Bowring J, Balleine BW, Mor D et al.

Repeated restraint stress (RRS) in rats impairs cognitive flexibility, particularly when faced with additional mild acute stress (AS). We tested the hypothesis that this impairment is associated with altered dopaminergic activity in the dorsal striatum (DS) driven by corticotropin-releasing-facto...

Tshering S, Qayyum W, Kapoor A

This report describes the case of a 41-year-old woman who presented with Addison's disease, manifesting as hypercalcaemia, acute kidney injury, and anxiety. She experienced progressive weight loss, fatigue, vomiting, dizziness, and anxiety over three months. Initial laboratory investigations reve...

Kilinc A, Kizildag B, Doganer A, Gul K, Oguz A

A common incidental radiological finding in asymptomatic adults is primary empty sella (PES). We examined the clinical, radiological and hormonal features of patients with PES to identify risk factors and guide follow-up strategies.The study included 120 patients with PES. Data on patients was ob...

Sakurai A, Hakata T, Yamauchi I, Kimura S, Kosugi D, Sugawa T et al.

Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment but are associated with immune-related adverse events (irAEs), including pituitary dysfunction. Combination immunotherapy with PD-1 and CTLA-4 inhibitors increases the risk of pituitary irAEs compared to PD-1 monotherapy; ho...

Zhang Z, Xu S, Li X, Liu Y, Liu C, Zhou J et al.

This study aimed to evaluate the diagnostic performance of [68Ga]Ga-DOTATATE PET/CT or PET/MR in comparison to dynamic MR (dMR) in locating ACTH-secreting pituitary adenomas in Cushing's disease (CD). The utility of PET and MR semi-quantitative parameters was additionally explored as non-invasive...

P E, Sa H, L V, Vlr G, Afø F, Ce T et al.

To establish sex- and age-specific reference intervals for plasma concentrations of adrenocorticotropic hormone (ACTH) and direct renin in healthy youth.529 healthy subjects (5.8 to 20.4 years) were recruited as part of the third Copenhagen Puberty Study, an ongoing cross-sectional study of healt...

Tuli G, Munarin J, Ragazzi P, Biasin E, Vallero SG, Bertin D et al.

Survivors of childhood brain tumors are at high risk of hypothalamic-pituitary dysfunction, but comparative data across cancer histotypes and treatment modalities are limited. This study evaluated the prevalence, risk factors, and timing of onset of hypothalamic-pituitary disorders in a large coh...

Duan Y, Zhao Q, Lu Y, Li S, Wu W, Li E et al.

GABA, an important inhibitory neurotransmitter that exhibits diverse biological functions, has been widely investigated for its immunomodulatory effects. However, its immunomodulatory mechanisms in Penaeus vannamei under low-salinity stress remain unclear. Penaeus vannamei was used as a model org...

Cai XX, Liao JS, Ma JJ, Pang YX, Chen YG, Lin YC et al.

MicroRNAs (miRNAs) are pivotal post‑transcriptional regulators whose single‑cell behavior has remained largely inaccessible due to technical barriers in single-cell small‑RNA profiling. We present SiCmiR, a two‑layer neural network that predicts miRNA expression profil...

Chen Y, Qiao N, Niu X, Zhao Y, Yu J, Wu G et al.

Immunohistochemistry (IHC) for lineage-defining transcription factors-such as Pit1, Tpit, and SF1-together with markers like Ki67 and ACTH, is central to classifying pituitary neuroendocrine tumors and guiding management. Yet preparing multiple IHC slides beyond hematoxylin-eosin (H&E) is cos...

Feinmesser D, Shohat S, Gerda R, Nin Nun A, Shoshani A, Samra NN et al.

This cross-sectional study investigated the relationship between depressive symptoms and creative personality through the lens of epigenetic modifications within Hypothalamic-Pituitary-Adrenal (HPA) axis genes. By analyzing DNA methylation patterns in key HPA axis genes-including corticotropin-re...

Joubert N, Mels CMC, Louw R, Chung ST, Wentzel A

Allostatic load scores (ALSs) quantify the cumulative physiological burden of sustained stress across neuro-endocrine, metabolic, cardiovascular and inflammatory domains; however ALS is heterogeneous in nature. Using domain-specific urinary metabolomic signatures may improve evaluation accuracy, ...

Ng IKS, Goh WGW, Tan LF, Teo DB

Gout is an increasingly prevalent condition with high global burden of disease due to a myriad of factors, including population ageing, rising affluence, changes in dietary habits and higher rates of obesity and metabolic syndrome. While many cases of gout flares can be managed with standard anti...

Thanekar R, Taksande B, Umekar M, Vinchurney M

Nicotine addiction is a chronic relapsing disorder driven by neuroadaptive changes in reward, stress, and emotional regulation systems. Withdrawal symptoms, including anxiety, irritability, cravings, and anhedonia, significantly hinder smoking cessation efforts. Despite current treatment options ...

Yan Y, Li J, Lu Z, Zhang Z, Hao G, Zhao Y et al.

Chronic stress and sustained hypothalamic-pituitary-adrenal (HPA) axis activation are major contributors to metabolic bone diseases, including osteoporosis. However, the precise molecular mechanisms by which chronic stress-induced HPA axis dysregulation drives bone deterioration remain unclear. A...