Cortexin Research

Dallari C, Ladurner G, Kendrisic M, Caria FF, Manzl C, Ponticelli L et al.

Non-invasive biomarkers for early Alzheimer's disease (AD) screening remain a critical unmet need. Current cerebrospinal fluid (CSF) assays, while highly informative, are invasive and unsuitable for large-scale or repeat testing, whereas blood-based biomarkers, despite recent diagnostic advances,...

Chutko LS, Yakovenko EA, Surushkina SY, Didur MD, Cherednichenko DV, Scheglova LV et al.

The aim of this study was to examine the clinical and psychophysiological characteristics of children with attention deficit hyperactivity disorder (ADHD), characterized by «problematic internet use» (PIU).The study group included 43 children aged 12-14 years with the most common combin...

Wang D, Li P

Depression is a prevalent mental disorder in modern society, with a complex and incompletely understood etiology. Accumulating evidence indicates that pesticide exposure is a potential risk factor for mental health disorders. Atrazine (ATR), a widely used herbicide with the highest global applica...

Rubel AD, Gumenyuk LN, Bobrik YV

The investigation of potential treatment methods for post-COVID syndrome with neurological manifestations within the framework of randomized controlled trials remains one of the priority tasks.To compare the effects of pharmacotherapy alone versus pharmacotherapy combined with transcranial electr...

Fedin AI, Khairova EN, Artyukov OP, Timchenko LV, Bazhenova OA, Gaiduk NV et al.

Study of the therapeutic equivalence of forms for intramuscular and intravenous administration of the drug Cortexin in patients in the acute and early recovery periods of ischemic stroke (IS).A multicenter, randomized, double-blind, placebo-controlled, parallel-group clinical trial was conducted....

Rappeneau V, Castillo Díaz F

Social behaviour is fundamental to survival and adaptation, relying on complex, interacting neurobiological systems in which the neuropeptide oxytocin (OT) and the neurotransmitter dopamine (DA) play pivotal roles in regulating social bonding, motivation, and reward processing. This review synthe...

Nguyen KQ, Rymar VV, Sadikot AF

Huntington's Disease (HD) is characterized by prominent degeneration of the principal neurons of the striatum and by progressive motor and cognitive deterioration. Striatal neurons degenerate in HD due to multiple cell-autonomous and non-autonomous factors. Impaired neurotrophin signaling by brai...

Wang Z, Ranasinghe JC, Chan DCY, Gomm A, Tanzi RE, Zhang C et al.

Label-free molecular imaging that enables the construction of a molecular atlas of biological tissues is vital for understanding complex physiological and pathological processes. Conventional bioimaging modalities, including positron-emission tomography (PET), magnetic-resonance imaging (MRI), im...

Droby A, Kurkure M, Haynes CR, Maidan I, Habeck CG, Hausdorff JM et al.

Amyloid beta (Aβ) deposition has been implicated in the disruption of neuronal activity and large-scale network connectivity in older adults, contributing to impairments in cognitive function and mobility. Nevertheless, the extent to which regional patterns of Aβ accumulation differen...

Weissmann C, Castellanos LCS, Montes MM, Uruk G, Youssef H, Reichard RR et al.

Tau protein isoforms, regulated during development, are influenced by the nuclear factor TDP-43, which plays a crucial role in tau mRNA stability and exon 10 inclusion. Both tau and TDP-43 are prone to pathological phosphorylation and aggregation, with specific phosphorylated forms of TDP-43 link...

Nani JV, Hayashi JY, Campeiro JD, Câmara GA, Saito A, Oyadomari WY et al.

The oligopeptidase Ndel1 (NudE neurodevelopment protein 1 like 1) is a multifunctional protein implicated in neurodevelopmental processes, intensively investigated as a potential biomarker in psychiatric disorders. While its roles in regulating the cytoskeleton are well-studied, the global conseq...

Ribeiro RT, Palavro R, Zeminiaçak ÂB, Zanatta Â, Castro ET, Cunha Cunha SA et al.

3-Hydroxyisobutyric acid dehydrogenase (HIBADH) deficiency is biochemically characterized by tissue accumulation of L-3-hydroxyisobutyric acid (3HIBA). Some patients manifest neurologic symptoms and cerebral magnetic resonance imaging abnormalities whose pathophysiology is unknown. We evaluated t...

Oulé M, Badrinarayanan S, Sundar-Maccagno R, Brandon MP

Vasoactive intestinal peptide (VIP) cells have emerged as a crucial component of the inhibitory network, facilitating interregional communication, particularly in the context of associative memory. To expand our current understanding of the role of this population, we combine anatomical and funct...

Esteve-Pérez R, Sevilla-Ferrer P, Lanuza E, Herranz-Pérez V, Torres-Pérez JV, Agustín-Pavón C et al.

Rett Syndrome (RTT) is a neurodevelopmental disorder which mainly affects girls, leading to profound impairments in motor function, loss of speech, intellectual disability, and epilepsy, among other symptoms. Most cases are caused by mutations in the X-linked MECP2 gene, which encodes the methyl-...

Zheng K, Wang W, Dai J, Jian L, Zhao X

Depression is a mental disorder, and the complexity of its pathogenesis affects the treatment and prevention of depression. Flavonoids possess a variety of biological effects, including antidepressant properties. Quercetin, a natural flavonoid, exhibits antioxidant, antidepressant and anti-inflam...

Casingal CR, Nakagawa N, Yabuno-Nakagawa K, Meyer C, Liu S, Gkini V et al.

The appropriate generation of upper-layer neurons is necessary to create the circuits that underlie complex brain functions. Radial progenitors divide asymmetrically to generate neurogenic intermediate progenitors (IPs; also known as intermediate precursors), and the symmetric proliferation of IP...

Machado RS, Mathias K, Coral C, Dos Santos D, Bonfante SRSA, de Souza Stork S et al.

Diabetes mellitus (DM) contributes to vascular complications through inflammation, endothelial dysfunction, oxidative stress, and mitochondrial impairment. Ischemic stroke (IS) is a common complication of DM and a leading cause of long-term neurological disability. Although DM elevates the risk o...

Liu X, Yuan L, Chu Q, Liu Y, Zhao T, Zhang Y et al.

Schizophreniais a severe mental disorder with complex behavioral pathology and complexgenetic risk.Here, we performed an integrated transcriptomic analysis of the prefrontal cortexin two distinct male C57BL/6J mouse modelsof schizophrenia,the neurodevelopmental methylazoxymethanol acetate (MAM) m...

Ciric J, Perovic M, Milovanovic N, Polaka S, Jovanovic Macura I, Nestorovic N et al.

The present study demonstrates the effects of an every-other-day (EOD) feeding regimen on parvalbumin (PV)-expressing interneurons in the cortex of 5xFAD mice, a well-established animal model of Alzheimer's disease (AD). Female 5xFAD mice and their non-transgenic littermates were maintained on ei...

Ramirez-Sanchez I, Salas-Gutierrez V, Ordoñez-Razo R, Ortiz-Vilchis P, Calzada-Mendoza C, Najera V et al.

Background/Objectives: We previously reported that the flavanol (+)-epicatechin (+Epi) enhances adult mice short-term working memory and neurogenesis. This study aimed to characterize the effects of +Epi on short- and long-term memory, to modulate mitochondria structure/function, oxidative stress...