Collagen Peptides Research

Salawudeen T, Jomrit J, Kaewpradit S, Nokkaew N, Jantarat C

Acne is a chronic inflammatory skin disorder commonly treated with topical antibiotics, whose long-term use is limited by antimicrobial resistance and adverse effects. Tea tree oil (TTO) is a natural antimicrobial agent effective against acne-associated bacteria; however, its clinical application...

Hu YT, Tu ZC, Liu GX, Peng CY, Zhang P, Xie WM et al.

Enzyme selection critically impacts porcine collagen peptide properties and identification. In this study, seven enzymes, namely alkaline protease, neutral protease, papain, compound protease, flavourzyme, pepsin, and trypsin, were used to hydrolyze porcine gelatin, significantly altering peptide...

Li Z, Li H, Zhang S, Wang X, Ji X, Zhang J et al.

High myopia (HM) poses a growing public health challenge due to its increasing prevalence and the associated risks of blinding complications and psychological comorbidities. While traditionally considered an isolated ocular condition, emerging evidence implicates systemic mechanisms, notably thro...

Dunne JB, Rujchanarong D, Park Y, Spruill L, Jensen-Smith H, Schwamborn K et al.

Collagen breast stroma can become a breast cancer risk factor, yet proteomic regulation of normal breast stroma remains poorly defined. This study evaluates the spatial regulation of the collagen proteome from normal breast tissue. Normal breast tissue sections from the Susan G. Komen tissue bank...

Platon N, Pârvulescu OC, Aruș VA, Georgescu AM, Silion M, Miron A et al.

Hydrolyzed collagen (HC) and konjac glucomannan (KGM) were used as additives in non-frozen and frozen doughs (NFDs and FDs). Both additives were characterized using specific techniques, i.e., SEM-EDX, MALDI-TOF MS, TGA, and DSC analyses. Rheological analysis of NFD samples was performed using a C...

Bruno A, D'Antimi A

Protein intake plays a critical role in postoperative recovery and wound healing, particularly in procedures such as abdominoplasty. While ERAS protocols emphasize nutritional optimization, evidence in non-bariatric patients undergoing elective body contouring remains limited.To evaluate the effe...

Xie X, Zhang MT, Huang CL, Wang JY, Ding Q, Xiong YX et al.

Tilapia (Oreochromis mossambicus) skin, as a by-product with high collagen, is an excellent source of calcium carriers to develop novel functional food for osteoporosis. In this study, tilapia skin collagen peptides (TSCP) were used to prepare peptides‑calcium chelates (TSCP-Ca), and the s...

González-Rodríguez Y, La Nuez-García MA, Jiménez M, Villar-Suárez V, Casado-Santos A

This study aimed to investigate the impact of fresh eggshell membrane (MKARE®) as a nutricosmetic ingredient, with a focus on its influence on skin properties. Biomechanical measurement devices were used to assess the effects on skin condition, and the results were compared with hydrolyzed c...

Casas-Flórez D, Ortega-García R, Sanz-Benito P, Monterroso B, Sanz-Aparicio J, González B et al.

The enzyme glucosylgalactosylhydroxylysine glucosidase (PGGHG) plays a critical role in collagen metabolism by hydrolyzing the 2-O-α-d-glucopyranosyl-O-β-d-galactopyranose, a natural disaccharide found in the glycosylation of hydroxylysine residues in collagen. We report the X-ray cry...

Pascale C, Burcea A, Bogdan-Andreescu CF, Cadar E, Popescu A, Negreanu-Pirjol T et al.

Background/Objectives: Oral squamous cell carcinoma (OSCC) remains a major therapeutic challenge due to treatment-related toxicity and impaired oral tissue regeneration. This study aimed to develop and characterize a novel biocomposite based on bioactive compounds from Ganoderma lucidum incorpora...

Cooper G, Gumbs JA, Alkharabsheh S, Lee KJ, Carter A, Coleman H et al.

Dupuytren's disease is a fibroproliferative disorder of the palmer fascia (PF) characterised by flexion contractures in the hand. Dupuytren's disease can be treated surgically, but disease recurrence rates are high, potentially due to continual production of matrisomal proteins. Here, metabolic l...

Paula-Vieira RHR, Dias SR, Silva-Reis A, Moura-Maia MS, Ramos-Gomes NV, Jesus-Silva K et al.

Collagen peptides are widely used to support skin health, but the immunological mechanisms mediating such effects remain unclear. So, this study investigated the effects of bioactive collagen peptide (BCP) supplementation on facial wrinkles, skin biophysical properties, and systemic levels of tra...

Schurman CA, Bons J, Woo JJ, Yee C, Liu Q, Tao N et al.

Osteoarthritis (OA) is a degenerative skeletal condition marked by the loss of articular cartilage and changes to subchondral bone homeostasis. Treatments for OA beyond full joint replacement are lacking primarily due to gaps in molecular knowledge of the biological drivers of disease. Mass Spect...

Wang R, Jiang M, Li Z, Zhao Z, Shen J

Cancer-associated fibroblasts (CAFs) are a critical component of the tumor microenvironment and play a significant role in renal cell carcinoma (RCC) progression and treatment response. However, current methods for evaluating CAFs infiltration in RCC are inadequate. This study aims to develop a n...

Canty-Laird EG, Gupta HS, Birch HL

The world population is ageing rapidly. The over-60s now outnumber the under- 5s, and 1 in 6 people will be over 60 by 2030 (WHO). Collagen is a key structural component of many tissues and organs, and although a fraction of the collagenous component of tissues is remarkably long-lived, it progre...

Coe M, Pallack EL, Patel DD, Kaplan DL, Iyer NR

In vitro tissue models are critical to our understanding of human cell functions and interactions, but their limited complexity can hinder translation to in vivo systems. Bioengineered 3D tissues are gradually improving the capabilities of in vitro models, but the highly complex spatial organizat...

Weng H, Decarli MC, Chen W, Bernaerts KV, Moroni L

Natural hydrogels (e.g., collagen hydrogels) show good potential in understanding cell-matrix interaction and find application in tissue engineering. However, it remains challenging to bioprint cell-laden natural hydrogels with good printability, shape retention and stability. In this study, non-...

Fernandes R, Oliveira C, Ferreira-Sousa D, Costa-Barbosa A, Sampaio P, Reis L et al.

Collagen, the most abundant structural protein in animals, is fundamental for tissue integrity and regeneration. Conventional mammalian sources face limitations related to sustainability, safety, and ethical concerns, underscoring the need for alternative biomaterials. Marine organisms, particula...

Coelho CB, Dos Santos Cerqueira Alves C, Novaes GUM, Segundo RSB, Rocha FOB, de Andrade Souza Magalhães JM et al.

The use of medicinal plant extracts in the repair of dermal wounds has been widely discussed in the literature, especially those based on collagen, due to the diverse biological activities conferred by these extracts in combination with the biocompatibility and interactivity of the material. This...

Wisdom EC, Aduba DC, Lewis O, Xavier S, Phillips EON, Gilchrist KH et al.

Bioengineered dermal-epidermal composites (DECs) have demonstrated promise initiating skin regeneration and hair follicle neogenesis after injury. DECs in our work comprise a collagen matrix embedded with human dermal papilla cells (HDPCs) overlaid with human keratinocytes. HDPCs, as three-dimens...